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Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women
M. Brezinova, T. Cajka, M. Oseeva, M. Stepan, K. Dadova, L. Rossmeislova, M. Matous, M. Siklova, M. Rossmeisl, O. Kuda,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, randomizované kontrolované studie, práce podpořená grantem
Grantová podpora
NV16-29182A
MZ0
CEP - Centrální evidence projektů
- MeSH
- cvičení fyziologie MeSH
- estery metabolismus MeSH
- inzulin metabolismus MeSH
- kombinovaná terapie MeSH
- kyselina palmitová metabolismus MeSH
- kyseliny stearové metabolismus MeSH
- lidé MeSH
- lipidomika MeSH
- lipogeneze fyziologie MeSH
- metabolický syndrom metabolismus patofyziologie prevence a kontrola MeSH
- omega-3 mastné kyseliny aplikace a dávkování MeSH
- potravní doplňky MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stárnutí fyziologie MeSH
- tuková tkáň metabolismus MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
Adverse effects of aging can be delayed with life-style interventions. We examined how exercise training (ET) alone or combined with omega-3 polyunsaturated fatty acid (PUFA) affects serum and adipose tissue (AT) lipidome in older women. Fifty-five sedentary older women were included in the physical activity program and given either sunflower (Placebo) or wax esters-rich (Calanus) oil capsules for 4 months. Serum and subcutaneous abdominal AT samples were acquired while maximum rates of oxygen consumption (VO2 max), insulin sensitivity (hyperinsulinemic-euglycemic clamps) and comprehensive lipidome profiles were determined before and after the study. ET increased VO2 max in both groups. Lipidomics profiling revealed unusual serum triacylglycerols and phospholipids with ether-bound alkyls in the Calanus group, while ET generally induced shorter-chain triacylglycerols in AT, suggesting increased de novo lipogenesis. The latter was positively associated with whole-body insulin sensitivity. Unexpectedly, insulin-sensitizing lipokines from the family of branched palmitic acid esters of hydroxy stearic acid (PAHSAs) were elevated in both serum and AT after ET, while PAHSAs-containing triacylglycerols were detected in AT. ET stimulated beneficial changes in AT, including PAHSAs synthesis. Although the added value of omega-3 PUFA supplementation was not proven, our discovery can help understand the nature of the metabolic benefits of exercise.
Institute of Physiology of the Czech Academy of Sciences Videnska 1083 14220 Prague 4 Czech Republic
Citace poskytuje Crossref.org
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- $a Adverse effects of aging can be delayed with life-style interventions. We examined how exercise training (ET) alone or combined with omega-3 polyunsaturated fatty acid (PUFA) affects serum and adipose tissue (AT) lipidome in older women. Fifty-five sedentary older women were included in the physical activity program and given either sunflower (Placebo) or wax esters-rich (Calanus) oil capsules for 4 months. Serum and subcutaneous abdominal AT samples were acquired while maximum rates of oxygen consumption (VO2 max), insulin sensitivity (hyperinsulinemic-euglycemic clamps) and comprehensive lipidome profiles were determined before and after the study. ET increased VO2 max in both groups. Lipidomics profiling revealed unusual serum triacylglycerols and phospholipids with ether-bound alkyls in the Calanus group, while ET generally induced shorter-chain triacylglycerols in AT, suggesting increased de novo lipogenesis. The latter was positively associated with whole-body insulin sensitivity. Unexpectedly, insulin-sensitizing lipokines from the family of branched palmitic acid esters of hydroxy stearic acid (PAHSAs) were elevated in both serum and AT after ET, while PAHSAs-containing triacylglycerols were detected in AT. ET stimulated beneficial changes in AT, including PAHSAs synthesis. Although the added value of omega-3 PUFA supplementation was not proven, our discovery can help understand the nature of the metabolic benefits of exercise.
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