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Assessment of Predictors of Left Atrial Volume Response to a Transcatheter InterAtrial Shunt Device (from the REDUCE LAP-HF Trial)

TC. Hanff, DM. Kaye, CS. Hayward, MC. Post, F. Malek, G. Hasenfuβ, F. Gustafsson, D. Burkhoff, SJ. Shah, SE. Litwin, R. Kahwash, SL. Hummel, BA. Borlaug, SD. Solomon, CSP. Lam, J. Komtebedde, FE. Silvestry, REDUCE LAP-HF study investigators, and...

. 2019 ; 124 (12) : 1912-1917. [pub] 20190926

Language English Country United States

Document type Clinical Trial, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc20023328

Grant support
R01 HL107577 NHLBI NIH HHS - United States
R01 HL127028 NHLBI NIH HHS - United States
R01 HL140731 NHLBI NIH HHS - United States

E-resources Online Full text

NLK ProQuest Central from 2012-08-15 to 2 months ago
Nursing & Allied Health Database (ProQuest) from 2012-08-15 to 2 months ago
Health & Medicine (ProQuest) from 2012-08-15 to 2 months ago

Links

PubMed 31653352
DOI 10.1016/j.amjcard.2019.09.019
Knihovny.cz E-resources

In patients with heart failure and preserved or mildly reduced ejection fractions (EF ≥40%), implantation of an interatrial shunt device (IASD) resulted in heterogenous changes of the left atrial (LA) volume. Baseline characteristics that correlate with a favorable decrease in LA volume are unknown. We hypothesized that a larger ratio of left to right atrial volume at baseline would correlate strongly with LA volume decongestion following IASD implantation. Reduce Elevated LA Pressure in Patients With Heart Failure was a multicenter study of the safety and feasibility of IASD implantation. Sixty-four patients with EF ≥40% underwent device implantation along with baseline conventional echocardiograms, speckle tracking echocardiography, and resting and exercise hemodynamics. Higher LA compliance (-4.2%, p = 0.048) and right atrial reservoir strain (-0.8%, p = 0.005) were independently associated with a percent decrease in the systolic LA volume index from baseline to 6-months. In conclusion, greater LA volume reduction following IASD implantation is associated with higher baseline compliance of the left atrium and higher reservoir strain of the right atrium.

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