Assessment of Predictors of Left Atrial Volume Response to a Transcatheter InterAtrial Shunt Device (from the REDUCE LAP-HF Trial)
Language English Country United States Media print-electronic
Document type Clinical Trial, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Grant support
R01 HL107577
NHLBI NIH HHS - United States
R01 HL127028
NHLBI NIH HHS - United States
R01 HL140731
NHLBI NIH HHS - United States
PubMed
31653352
DOI
10.1016/j.amjcard.2019.09.019
PII: S0002-9149(19)31058-6
Knihovny.cz E-resources
- MeSH
- Echocardiography, Doppler methods MeSH
- Adult MeSH
- Ventricular Function, Left physiology MeSH
- Hemodynamics physiology MeSH
- Risk Assessment MeSH
- Prosthesis Implantation methods MeSH
- Cardiac Surgical Procedures methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Linear Models MeSH
- Survival Rate MeSH
- Multivariate Analysis MeSH
- Predictive Value of Tests MeSH
- Prognosis MeSH
- Prospective Studies MeSH
- Prostheses and Implants * MeSH
- Cardiac Catheterization methods MeSH
- Heart Failure diagnostic imaging mortality surgery MeSH
- Heart Atria physiopathology MeSH
- Severity of Illness Index MeSH
- Stroke Volume MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Multicenter Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
In patients with heart failure and preserved or mildly reduced ejection fractions (EF ≥40%), implantation of an interatrial shunt device (IASD) resulted in heterogenous changes of the left atrial (LA) volume. Baseline characteristics that correlate with a favorable decrease in LA volume are unknown. We hypothesized that a larger ratio of left to right atrial volume at baseline would correlate strongly with LA volume decongestion following IASD implantation. Reduce Elevated LA Pressure in Patients With Heart Failure was a multicenter study of the safety and feasibility of IASD implantation. Sixty-four patients with EF ≥40% underwent device implantation along with baseline conventional echocardiograms, speckle tracking echocardiography, and resting and exercise hemodynamics. Higher LA compliance (-4.2%, p = 0.048) and right atrial reservoir strain (-0.8%, p = 0.005) were independently associated with a percent decrease in the systolic LA volume index from baseline to 6-months. In conclusion, greater LA volume reduction following IASD implantation is associated with higher baseline compliance of the left atrium and higher reservoir strain of the right atrium.
Alfred Hospital and Baker Heart and Diabetes Institute Melbourne Victoria Australia
Brigham and Women's Hospital Boston Massachusetts
Cardiovascular Research Foundation New York New York
Corvia Medical Boston Massachusetts
Department of Cardiology Rigshospitalet Copenhagen Denmark
Duke National University of Singapore Singapore
Heart Centre Georg August University Gottingen Germany
Hospital of the University of Pennsylvania Philadelphia Pennsylvania
Mayo Clinic College of Medicine Rochester Minnesota
Medical University of South Carolina Charleston South Carolina
Na Homolce Hospital Prague Czech Republic
Northwestern University Feinberg School of Medicine Chicago Illinois
Ohio State University Wexner Medical Center Columbus Ohio
St Antonius Hospital Nieuwegein The Netherlands
St Vincent's Hospital Sydney New South Wales Australia
University of Michigan and VA Ann Arbor Healthcare System Ann Arbor Michigan
References provided by Crossref.org
ClinicalTrials.gov
NCT01913613
