Assessment of Predictors of Left Atrial Volume Response to a Transcatheter InterAtrial Shunt Device (from the REDUCE LAP-HF Trial)
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu klinické zkoušky, časopisecké články, multicentrická studie, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
R01 HL107577
NHLBI NIH HHS - United States
R01 HL127028
NHLBI NIH HHS - United States
R01 HL140731
NHLBI NIH HHS - United States
PubMed
31653352
DOI
10.1016/j.amjcard.2019.09.019
PII: S0002-9149(19)31058-6
Knihovny.cz E-zdroje
- MeSH
- dopplerovská echokardiografie metody MeSH
- dospělí MeSH
- funkce levé komory srdeční fyziologie MeSH
- hemodynamika fyziologie MeSH
- hodnocení rizik MeSH
- implantace protézy metody MeSH
- kardiochirurgické výkony metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- lineární modely MeSH
- míra přežití MeSH
- multivariační analýza MeSH
- prediktivní hodnota testů MeSH
- prognóza MeSH
- prospektivní studie MeSH
- protézy a implantáty * MeSH
- srdeční katetrizace metody MeSH
- srdeční selhání diagnostické zobrazování mortalita chirurgie MeSH
- srdeční síně patofyziologie MeSH
- stupeň závažnosti nemoci MeSH
- tepový objem MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
In patients with heart failure and preserved or mildly reduced ejection fractions (EF ≥40%), implantation of an interatrial shunt device (IASD) resulted in heterogenous changes of the left atrial (LA) volume. Baseline characteristics that correlate with a favorable decrease in LA volume are unknown. We hypothesized that a larger ratio of left to right atrial volume at baseline would correlate strongly with LA volume decongestion following IASD implantation. Reduce Elevated LA Pressure in Patients With Heart Failure was a multicenter study of the safety and feasibility of IASD implantation. Sixty-four patients with EF ≥40% underwent device implantation along with baseline conventional echocardiograms, speckle tracking echocardiography, and resting and exercise hemodynamics. Higher LA compliance (-4.2%, p = 0.048) and right atrial reservoir strain (-0.8%, p = 0.005) were independently associated with a percent decrease in the systolic LA volume index from baseline to 6-months. In conclusion, greater LA volume reduction following IASD implantation is associated with higher baseline compliance of the left atrium and higher reservoir strain of the right atrium.
Alfred Hospital and Baker Heart and Diabetes Institute Melbourne Victoria Australia
Brigham and Women's Hospital Boston Massachusetts
Cardiovascular Research Foundation New York New York
Corvia Medical Boston Massachusetts
Department of Cardiology Rigshospitalet Copenhagen Denmark
Duke National University of Singapore Singapore
Heart Centre Georg August University Gottingen Germany
Hospital of the University of Pennsylvania Philadelphia Pennsylvania
Mayo Clinic College of Medicine Rochester Minnesota
Medical University of South Carolina Charleston South Carolina
Na Homolce Hospital Prague Czech Republic
Northwestern University Feinberg School of Medicine Chicago Illinois
Ohio State University Wexner Medical Center Columbus Ohio
St Antonius Hospital Nieuwegein The Netherlands
St Vincent's Hospital Sydney New South Wales Australia
University of Michigan and VA Ann Arbor Healthcare System Ann Arbor Michigan
Citace poskytuje Crossref.org
ClinicalTrials.gov
NCT01913613
