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Consensus statements on the approach to patients in a methanol poisoning outbreak

H. Hassanian-Moghaddam, N. Zamani, DM. Roberts, J. Brent, K. McMartin, C. Aaron, M. Eddleston, PI. Dargan, K. Olson, L. Nelson, A. Bhalla, P. Hantson, D. Jacobsen, B. Megarbane, M. Balali-Mood, NA. Buckley, S. Zakharov, R. Paasma, B. Jarwani, A....

. 2019 ; 57 (12) : 1129-1136. [pub] 20190722

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc20023378

Grantová podpora
NV16-27075A MZ0 CEP - Centrální evidence projektů

Background: Methanol poisoning is an important cause of mortality and morbidity worldwide. Although it often occurs as smaller sporadic events, epidemic outbreaks are not uncommon due to the illicit manufacture and sale of alcoholic beverages.Objective: We aimed to define methanol poisoning outbreak (MPO), outline an approach to triaging an MPO, and define criteria for prioritizing antidotes, extracorporeal elimination treatments (i.e., dialysis), and indications for transferring patients in the context of an MPO.Methods: We convened a group of experts from across the world to explore geographical, socio-cultural and clinical considerations in the management of an MPO. The experts answered specific open-ended questions based on themes aligned to the goals of this project. This project used a modified Delphi process. The discussion continued until there was condensation of themes.Results: We defined MPO as a sudden increase in the number of cases of methanol poisoning during a short period of time above what is normally expected in the population in that specific geographic area. Prompt initiation of an antidote is necessary in MPOs. Scarce hemodialysis resources require triage to identify patients most likely to benefit from this treatment. The sickest patients should not be transferred unless the time for transfer is very short. Transporting extracorporeal treatment equipment and antidotes may be more efficient.Conclusion: We have developed consensus statements on the response to a methanol poisoning outbreak. These can be used in any country and will be most effective when they are discussed by health authorities and clinicians prior to an outbreak.

California Poison Control System San Francisco Division University of California San Francisco San Francisco CA USA

Department of Acute Medicine Oslo University Hospital University of Oslo Oslo Norway

Department of Anesthesiology and ICU Pärnu County Hospital Pärnu Estonia

Department of Clinical biochemistry and pharmacology Tomas Bata Hospital ZLÍN Czech Republic

Department of Clinical Pharmacology and Toxicology and Department of Renal Medicine St Vincent's Hospital University of NSW Sydney NSW Australia NSW Poisons Information Centre Sydney Children's Hospital Westmead Sydney NSW Australia

Department of Clinical Toxicology Guy's and St Thomas' NHS Foundation Trust and Faculty of Life Sciences and Medicine King's College London London UK

Department of Emergency Medicine Kerman University of Medical Sciences Kerman Iran

Department of Emergency Medicine Rutgers New Jersey Medical School Newark NJ USA

Department of Emergency Medicine VSGH Ahmedabad India

Department of Medical and Toxicological Critical Care Lariboisière Hospital INSERM UMRS 1144 Paris Diderot University Paris France

Department of Occupational Medicine 1st Faculty of Medicine Charles University and General University Hospital Toxicological Information Centre Prague 2 Czech Republic

Department of Pharmacology Toxicology and Neuroscience Louisiana State University Health Sciences Center Shreveport Shreveport LA USA

Department of Pharmacology Toxicology and Therapeutics University BHF Centre for Cardiovascular Science University of Edinburgh Edinburgh UK

Department of Pharmacology University of Sydney Sydney Australia

Medical Toxicology Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran

Michigan Regional Poison Control Center at Children's Hospital of Michigan Detroit MI USA Emergency Medicine Wayne State University School of Medicine Detroit MI USA

Postgraduate Institute of Medical Education and Research Chandigarh India

School of Medicine University of Colorado Aurora CO USA

Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Clinical Toxicology Loghman Hakim Hospital School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran

The Norwegian CBRNE Centre of Medicine Department of Acute Medicine Oslo University Hospital Oslo Norway

Université catholique de Louvain Cliniques universitaires Saint Luc Bruxelles Department of Intensive Care Brussels Belgium Université catholique de Louvain Cliniques universitaires Saint Luc Bruxelles Louvain Centre for Toxicology and Applied Pharmacology Brussels Belgium

Citace poskytuje Crossref.org

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