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Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study
J. Burisch, G. Kiudelis, L. Kupcinskas, HAL. Kievit, KW. Andersen, V. Andersen, R. Salupere, N. Pedersen, J. Kjeldsen, R. D'Incà, D. Valpiani, D. Schwartz, S. Odes, J. Olsen, KR. Nielsen, Z. Vegh, PL. Lakatos, A. Toca, S. Turcan, KH. Katsanos,...
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
NLK
ProQuest Central
od 1960-03-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 1960-03-01 do Před 6 měsíci
- MeSH
- Crohnova nemoc epidemiologie patologie terapie MeSH
- dospělí MeSH
- glukokortikoidy terapeutické užití MeSH
- hospitalizace statistika a číselné údaje MeSH
- imunologické faktory terapeutické užití MeSH
- kohortové studie MeSH
- kolektomie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- nádory epidemiologie MeSH
- následné studie MeSH
- prognóza MeSH
- progrese nemoci MeSH
- prospektivní studie MeSH
- střevní obstrukce epidemiologie etiologie patologie MeSH
- stupeň závažnosti nemoci MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
OBJECTIVE: The Epi-IBD cohort is a prospective population-based inception cohort of unselected patients with inflammatory bowel disease from 29 European centres covering a background population of almost 10 million people. The aim of this study was to assess the 5-year outcome and disease course of patients with Crohn's disease (CD). DESIGN: Patients were followed up prospectively from the time of diagnosis, including collection of their clinical data, demographics, disease activity, medical therapy, surgery, cancers and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis. RESULTS: In total, 488 patients were included in the study. During follow-up, 107 (22%) patients received surgery, while 176 (36%) patients were hospitalised because of CD. A total of 49 (14%) patients diagnosed with non-stricturing, non-penetrating disease progressed to either stricturing and/or penetrating disease. These rates did not differ between patients from Western and Eastern Europe. However, significant geographic differences were noted regarding treatment: more patients in Western Europe received biological therapy (33%) and immunomodulators (66%) than did those in Eastern Europe (14% and 54%, respectively, P<0.01), while more Eastern European patients received 5-aminosalicylates (90% vs 56%, P<0.05). Treatment with immunomodulators reduced the risk of surgery (HR: 0.4, 95% CI 0.2 to 0.6) and hospitalisation (HR: 0.3, 95% CI 0.2 to 0.5). CONCLUSION: Despite patients being treated early and frequently with immunomodulators and biological therapy in Western Europe, 5-year outcomes including surgery and phenotype progression in this cohort were comparable across Western and Eastern Europe. Differences in treatment strategies between Western and Eastern European centres did not affect the disease course. Treatment with immunomodulators reduced the risk of surgery and hospitalisation.
1st Department of Medicine Semmelweis University Budapest Hungary
Clinic of Gastroenterology University of Medicine 'Victor Babes' Timisoara Romania
Department of Gastroenterology Faculty of Medicine and Health Örebro University Örebro Sweden
Department of Gastroenterology Herlev and Gentofte Hospital University of Copenhagen Herlev Denmark
Department of Gastroenterology Hospital POVISA Vigo Spain
Department of Gastroenterology Moscow Regional Research Clinical Institute Moscow Russian Federation
Department of Gastroenterology Nordsjællands Hospital University of Copenhagen Frederikssund Denmark
Department of Gastroenterology University Hospital of Ioannina Ioannina Greece
Department of Medicine Herning Central Hospital Herning Denmark
Division of Gastroenterology and Hepatology University Hospital Center Zagreb Zagreb Croatia
Division of Gastroenterology Mater Dei Hospital Msida Malta
Division of Gastroenterology Tartu University Hospital University of Tarty Tartu Estonia
Gastroenterology Department Odense University Hospital Odense Denmark
Gastroenterology Department Slagelse Hospital Slagelse Sjaelland Denmark
IBD Clinical and Research Centre ISCARE Prague Czech Republic
IBD Department Imperial College London London UK
IBD Unit Hull and East Yorkshire NHS Trust Hull UK
Medical Department Regional Hospital of Viborg Viborg Midtjylland Denmark
Medical Department The National Hospital of the Faroe Islands Thorshavn Faroe Islands
Nicosia private practice Nicosia Cyprus
U O Gastroenterologia ed Endoscopia digestiva Hospital Morgagni Pierantoni Forlì Italy
Citace poskytuje Crossref.org
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- $a Burisch, Johan $u Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark.
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- $a Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study / $c J. Burisch, G. Kiudelis, L. Kupcinskas, HAL. Kievit, KW. Andersen, V. Andersen, R. Salupere, N. Pedersen, J. Kjeldsen, R. D'Incà, D. Valpiani, D. Schwartz, S. Odes, J. Olsen, KR. Nielsen, Z. Vegh, PL. Lakatos, A. Toca, S. Turcan, KH. Katsanos, DK. Christodoulou, M. Fumery, C. Gower-Rousseau, SC. Zammit, P. Ellul, C. Eriksson, J. Halfvarson, FJ. Magro, D. Duricova, M. Bortlik, A. Fernandez, V. Hernández, S. Myers, S. Sebastian, P. Oksanen, P. Collin, A. Goldis, R. Misra, N. Arebi, IP. Kaimakliotis, I. Nikuina, E. Belousova, M. Brinar, S. Cukovic-Cavka, E. Langholz, P. Munkholm, Epi-IBD group,
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- $a OBJECTIVE: The Epi-IBD cohort is a prospective population-based inception cohort of unselected patients with inflammatory bowel disease from 29 European centres covering a background population of almost 10 million people. The aim of this study was to assess the 5-year outcome and disease course of patients with Crohn's disease (CD). DESIGN: Patients were followed up prospectively from the time of diagnosis, including collection of their clinical data, demographics, disease activity, medical therapy, surgery, cancers and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis. RESULTS: In total, 488 patients were included in the study. During follow-up, 107 (22%) patients received surgery, while 176 (36%) patients were hospitalised because of CD. A total of 49 (14%) patients diagnosed with non-stricturing, non-penetrating disease progressed to either stricturing and/or penetrating disease. These rates did not differ between patients from Western and Eastern Europe. However, significant geographic differences were noted regarding treatment: more patients in Western Europe received biological therapy (33%) and immunomodulators (66%) than did those in Eastern Europe (14% and 54%, respectively, P<0.01), while more Eastern European patients received 5-aminosalicylates (90% vs 56%, P<0.05). Treatment with immunomodulators reduced the risk of surgery (HR: 0.4, 95% CI 0.2 to 0.6) and hospitalisation (HR: 0.3, 95% CI 0.2 to 0.5). CONCLUSION: Despite patients being treated early and frequently with immunomodulators and biological therapy in Western Europe, 5-year outcomes including surgery and phenotype progression in this cohort were comparable across Western and Eastern Europe. Differences in treatment strategies between Western and Eastern European centres did not affect the disease course. Treatment with immunomodulators reduced the risk of surgery and hospitalisation.
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- 700 1_
- $a Gower-Rousseau, Corinne $u Public Health, Epidemiology and Economic Health, Registre Epimad, Lille University and Hospital, Lille, France. Lille Inflammation Research International Center LIRIC, Lille University, Lille, France.
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