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Young cryptogenic ischemic stroke: A descriptive analysis of clinical and laboratory characteristics, outcomes and stroke recurrence
P. Divišová, D. Šaňák, M. Král, A. Bártková, M. Hutyra, J. Zapletalová, T. Dorňák, M. Špaček, D. Franc, P. Polidar, T. Veverka, P. Kaňovský,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, pozorovací studie
Grantová podpora
NV17-30101A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
NLK
ROAD: Directory of Open Access Scholarly Resources
od 1991
- MeSH
- časové faktory MeSH
- cévní mozková příhoda diagnóza epidemiologie patofyziologie terapie MeSH
- dospělí MeSH
- echokardiografie transezofageální * MeSH
- elektrokardiografie ambulantní * MeSH
- hodnocení rizik MeSH
- inhibitory agregace trombocytů terapeutické užití MeSH
- ischemie mozku diagnóza epidemiologie patofyziologie terapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- obezita epidemiologie MeSH
- prediktivní hodnota testů MeSH
- prospektivní studie MeSH
- recidiva MeSH
- rizikové faktory MeSH
- věk při počátku nemoci MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
BACKGROUND AND PURPOSE: Ischemic strokes (IS) occur also in young adults and despite an extensive work-up the cause of IS remains very often cryptogenic. Thus, effectiveness of secondary prevention may be unclear. We aimed to analyze a relationship among vascular risk factors (VRF), clinical and laboratory parameters, outcomes and recurrent IS (RIS) in young cryptogenic IS (CIS) patients. SUBJECTS AND METHODS: The study set consisted of young acute IS patients < 50 years enrolled in the prospective HISTORY (Heart and Ischemic STrOke Relationship studY) study registered on ClinicalTrials.gov (NCT01541163). All analyzed patients underwent transesophageal echocardiography, 24-h and 3-week ECG-Holter to assess cause of IS according to the ASCOD classification. Recurrent IS (RIS) was recorded during a follow-up (FUP). RESULTS: Out of 294 young enrolled patients, 208 (70.7%, 113 males, mean age 41.6 ± 7.2 years) were identified as cryptogenic. Hyperlipidemia (43.3%), smoking (40.6%) and arterial hypertension (37.0%) were the most frequent VRF. RIS occurred in 7 (3.4%) patients during a mean time of FUP 19 ± 23 months. One-year risk of RIS was 3.4% (95%CI: 1.4-6.8%). Patients with RIS were older (47.4 vs. 41.1 years, p = 0.007) and more often obese (71.4 vs. 19.7%, p = 0.006), and did not differ in any of other analyzed parameters and VRF. Multivariate logistic regression analysis showed obesity (OR: 9.527; 95%CI: 1.777-51.1) and the previous use of antiplatelets (OR: 15.68; 95%CI: 2.430-101.2) as predictors of recurrent IS. CONCLUSION: Despite a higher presence of VRF in young CIS patients, the risk of RIS was very low. Obesity and previous use of antiplatelet therapy were found the only predictors of RIS.
Department of Biophysics and Statistics Palacký University Medical School Olomouc Czech Republic
Department of Cardiology Palacký University Medical School and Hospital Olomouc Czech Republic
Citace poskytuje Crossref.org
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