-
Something wrong with this record ?
G4Killer web application: a tool to design G-quadruplex mutations
V. Brazda, J. Kolomaznik, JL. Mergny, J. Stastny,
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1996 to 1 year ago
PubMed Central
from 2007
Open Access Digital Library
from 1996-01-01
Medline Complete (EBSCOhost)
from 1998-01-01
Oxford Journals Open Access Collection
from 1985-01-01 to 2022-09-30
Oxford Journals Open Access Collection
from 1985-01-01
ROAD: Directory of Open Access Scholarly Resources
from 1998
- MeSH
- Algorithms MeSH
- DNA MeSH
- G-Quadruplexes * MeSH
- Mutation MeSH
- Sequence Analysis, DNA MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
MOTIVATION: G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. RESULTS: We developed a web-based tool termed G4Killer that is based on the G4Hunter algorithm. This new tool is a platform-independent and user-friendly application to design mutations crippling G4 propensity in a parsimonious way (i.e., keeping the primary sequence as close as possible to the original one). The tool is integrated into our DNA analyzer server and allows for generating mutated DNA sequences having the desired lowered G4Hunter score with minimal mutation steps. AVAILABILITY AND IMPLEMENTATION: The G4Killer web tool can be accessed at: http://bioinformatics.ibp.cz. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Department of Informatics Mendel University in Brno Brno 613 00 Czech Republic
Institute of Biophysics of the Czech Academy of Sciences Brno 612 65 Czech Republic
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20028192
- 003
- CZ-PrNML
- 005
- 20210114153206.0
- 007
- ta
- 008
- 210105s2020 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1093/bioinformatics/btaa057 $2 doi
- 035 __
- $a (PubMed)31985802
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Brazda, Vaclav $u Institute of Biophysics of the Czech Academy of Sciences, Brno 612 65, Czech Republic.
- 245 10
- $a G4Killer web application: a tool to design G-quadruplex mutations / $c V. Brazda, J. Kolomaznik, JL. Mergny, J. Stastny,
- 520 9_
- $a MOTIVATION: G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. RESULTS: We developed a web-based tool termed G4Killer that is based on the G4Hunter algorithm. This new tool is a platform-independent and user-friendly application to design mutations crippling G4 propensity in a parsimonious way (i.e., keeping the primary sequence as close as possible to the original one). The tool is integrated into our DNA analyzer server and allows for generating mutated DNA sequences having the desired lowered G4Hunter score with minimal mutation steps. AVAILABILITY AND IMPLEMENTATION: The G4Killer web tool can be accessed at: http://bioinformatics.ibp.cz. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
- 650 _2
- $a algoritmy $7 D000465
- 650 _2
- $a DNA $7 D004247
- 650 12
- $a G-kvadruplexy $7 D054856
- 650 _2
- $a mutace $7 D009154
- 650 _2
- $a sekvenční analýza DNA $7 D017422
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Kolomaznik, Jan $u Department of Informatics, Mendel University in Brno, Brno 613 00, Czech Republic.
- 700 1_
- $a Mergny, Jean-Louis $u Institute of Biophysics of the Czech Academy of Sciences, Brno 612 65, Czech Republic.
- 700 1_
- $a Stastny, Jiri $u Department of Informatics, Mendel University in Brno, Brno 613 00, Czech Republic.
- 773 0_
- $w MED00008115 $t Bioinformatics (Oxford, England) $x 1367-4811 $g Roč. 36, č. 10 (2020), s. 3246-3247
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31985802 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20210105 $b ABA008
- 991 __
- $a 20210114153204 $b ABA008
- 999 __
- $a ok $b bmc $g 1608527 $s 1119372
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 36 $c 10 $d 3246-3247 $e 20200501 $i 1367-4811 $m Bioinformatics $n Bioinformatics $x MED00008115
- LZP __
- $a Pubmed-20210105
