• Je něco špatně v tomto záznamu ?

G4Killer web application: a tool to design G-quadruplex mutations

V. Brazda, J. Kolomaznik, JL. Mergny, J. Stastny,

. 2020 ; 36 (10) : 3246-3247. [pub] 20200501

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20028192

MOTIVATION: G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. RESULTS: We developed a web-based tool termed G4Killer that is based on the G4Hunter algorithm. This new tool is a platform-independent and user-friendly application to design mutations crippling G4 propensity in a parsimonious way (i.e., keeping the primary sequence as close as possible to the original one). The tool is integrated into our DNA analyzer server and allows for generating mutated DNA sequences having the desired lowered G4Hunter score with minimal mutation steps. AVAILABILITY AND IMPLEMENTATION: The G4Killer web tool can be accessed at: http://bioinformatics.ibp.cz. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20028192
003      
CZ-PrNML
005      
20210114153206.0
007      
ta
008      
210105s2020 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1093/bioinformatics/btaa057 $2 doi
035    __
$a (PubMed)31985802
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Brazda, Vaclav $u Institute of Biophysics of the Czech Academy of Sciences, Brno 612 65, Czech Republic.
245    10
$a G4Killer web application: a tool to design G-quadruplex mutations / $c V. Brazda, J. Kolomaznik, JL. Mergny, J. Stastny,
520    9_
$a MOTIVATION: G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. RESULTS: We developed a web-based tool termed G4Killer that is based on the G4Hunter algorithm. This new tool is a platform-independent and user-friendly application to design mutations crippling G4 propensity in a parsimonious way (i.e., keeping the primary sequence as close as possible to the original one). The tool is integrated into our DNA analyzer server and allows for generating mutated DNA sequences having the desired lowered G4Hunter score with minimal mutation steps. AVAILABILITY AND IMPLEMENTATION: The G4Killer web tool can be accessed at: http://bioinformatics.ibp.cz. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
650    _2
$a algoritmy $7 D000465
650    _2
$a DNA $7 D004247
650    12
$a G-kvadruplexy $7 D054856
650    _2
$a mutace $7 D009154
650    _2
$a sekvenční analýza DNA $7 D017422
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Kolomaznik, Jan $u Department of Informatics, Mendel University in Brno, Brno 613 00, Czech Republic.
700    1_
$a Mergny, Jean-Louis $u Institute of Biophysics of the Czech Academy of Sciences, Brno 612 65, Czech Republic.
700    1_
$a Stastny, Jiri $u Department of Informatics, Mendel University in Brno, Brno 613 00, Czech Republic.
773    0_
$w MED00008115 $t Bioinformatics (Oxford, England) $x 1367-4811 $g Roč. 36, č. 10 (2020), s. 3246-3247
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31985802 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20210105 $b ABA008
991    __
$a 20210114153204 $b ABA008
999    __
$a ok $b bmc $g 1608527 $s 1119372
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 36 $c 10 $d 3246-3247 $e 20200501 $i 1367-4811 $m Bioinformatics $n Bioinformatics $x MED00008115
LZP    __
$a Pubmed-20210105

Najít záznam

Citační ukazatele

Možnosti archivace