-
Je něco špatně v tomto záznamu ?
Prevalence and significance of M541L single nucleotide polymorphism in the central European cohort of gastrointestinal stromal tumor patients
K. Jasek, M. Grendar, A. Stanclova, B. Malicherova, I. Kasubova, T. Burjanivova, P. Szepe, R. Ciccocioppo, L. Rodrigo, R. Prosecky, P. Kruzliak, L. Plank, Z. Lasabova
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články
Grantová podpora
VEGA-1/0380/18
Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
NLK
ProQuest Central
od 1997-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2003-04-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 1997-01-01 do Před 1 rokem
Springer Nature OA/Free Journals
od 1904-02-01
- MeSH
- dospělí MeSH
- gastrointestinální nádory epidemiologie genetika patologie MeSH
- gastrointestinální stromální tumory epidemiologie genetika patologie MeSH
- jednonukleotidový polymorfismus * MeSH
- lidé středního věku MeSH
- lidé MeSH
- míra přežití MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nádorové biomarkery genetika MeSH
- následné studie MeSH
- prognóza MeSH
- protoonkogenní proteiny c-kit genetika MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
BACKGROUND: Single nucleotide polymorphisms can create a genetic microenvironment in some tumors that affects the course of treatment, resistance, etc. Whether single nucleotide polymorphisms have an impact on gastrointestinal stromal tumor (GIST) development and disease progression is not yet accurately verified. KIT SNPM541L in exon 10 correlates with a worse prognosis of many cancers. The impact of KIT SNPM541L in GISTs is relatively unknown and, therefore, its analyses could have potential in patient therapy and could provide more detailed information on tumor character, clinical presentation, or tumor behavior in treatment. AIM: The aim of the study was the analysis of the biological and clinical significance of the KIT SNPM541L polymorphism in exon 10. MATERIALS AND METHODS: Paraffin sample tissues were obtained from the National GIST Register in Martin. Retrospective samples from 177 GIST patients were divided into several groups. Detection of SNPM541L was performed by Sanger sequencing. Statisitical analyses were performed to determine the prevalence of KIT SNPM541L in the Slovak GIST cohort, to search for correlation between c-KIT status and clinicopathological, molecular and biological data. RESULTS: Overall, 29 samples out of 177 showed KIT SNPM541L polymorphism. CONCLUSION: Our results do not support the association between KIT SNPM541L and increased risk of relapse in localized primary GISTs. Additionally, we found a positive correlation between KIT SNPM541L occurrence and earlier onset of relapse in PDGFRa and WT subgroup of GISTs.
Department of Medicine A O U 1 Policlinico G B Rossi and University of Verona Verona Italy
Faculty of Medicine University of Oviedo Central University Hospital of Asturias Oviedo Spain
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21011409
- 003
- CZ-PrNML
- 005
- 20220617104503.0
- 007
- ta
- 008
- 210420s2021 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s00432-020-03410-8 $2 doi
- 035 __
- $a (PubMed)33044628
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Jasek, Karin $u Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
- 245 10
- $a Prevalence and significance of M541L single nucleotide polymorphism in the central European cohort of gastrointestinal stromal tumor patients / $c K. Jasek, M. Grendar, A. Stanclova, B. Malicherova, I. Kasubova, T. Burjanivova, P. Szepe, R. Ciccocioppo, L. Rodrigo, R. Prosecky, P. Kruzliak, L. Plank, Z. Lasabova
- 520 9_
- $a BACKGROUND: Single nucleotide polymorphisms can create a genetic microenvironment in some tumors that affects the course of treatment, resistance, etc. Whether single nucleotide polymorphisms have an impact on gastrointestinal stromal tumor (GIST) development and disease progression is not yet accurately verified. KIT SNPM541L in exon 10 correlates with a worse prognosis of many cancers. The impact of KIT SNPM541L in GISTs is relatively unknown and, therefore, its analyses could have potential in patient therapy and could provide more detailed information on tumor character, clinical presentation, or tumor behavior in treatment. AIM: The aim of the study was the analysis of the biological and clinical significance of the KIT SNPM541L polymorphism in exon 10. MATERIALS AND METHODS: Paraffin sample tissues were obtained from the National GIST Register in Martin. Retrospective samples from 177 GIST patients were divided into several groups. Detection of SNPM541L was performed by Sanger sequencing. Statisitical analyses were performed to determine the prevalence of KIT SNPM541L in the Slovak GIST cohort, to search for correlation between c-KIT status and clinicopathological, molecular and biological data. RESULTS: Overall, 29 samples out of 177 showed KIT SNPM541L polymorphism. CONCLUSION: Our results do not support the association between KIT SNPM541L and increased risk of relapse in localized primary GISTs. Additionally, we found a positive correlation between KIT SNPM541L occurrence and earlier onset of relapse in PDGFRa and WT subgroup of GISTs.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a nádorové biomarkery $x genetika $7 D014408
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a následné studie $7 D005500
- 650 _2
- $a gastrointestinální nádory $x epidemiologie $x genetika $x patologie $7 D005770
- 650 _2
- $a gastrointestinální stromální tumory $x epidemiologie $x genetika $x patologie $7 D046152
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 12
- $a jednonukleotidový polymorfismus $7 D020641
- 650 _2
- $a prognóza $7 D011379
- 650 _2
- $a protoonkogenní proteiny c-kit $x genetika $7 D019009
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a míra přežití $7 D015996
- 650 _2
- $a mladý dospělý $7 D055815
- 651 _2
- $a Evropa $x epidemiologie $7 D005060
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Grendar, Marian $u Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
- 700 1_
- $a Stanclova, Andrea $u Department of Pathological Anatomy, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
- 700 1_
- $a Malicherova, Bibiana $u Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
- 700 1_
- $a Kasubova, Ivana $u Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
- 700 1_
- $a Burjanivova, Tatiana $u Department of Molecular Biology and Genomics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
- 700 1_
- $a Szepe, Peter $u Department of Pathological Anatomy, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
- 700 1_
- $a Ciccocioppo, Rachele $u Department of Medicine, A.O.U.I. Policlinico G.B. Rossi and University of Verona, Verona, Italy
- 700 1_
- $a Rodrigo, Luis $u Faculty of Medicine, University of Oviedo, Central University Hospital of Asturias (HUCA), Oviedo, Spain
- 700 1_
- $a Prosecký, Robert $u 2nd Department of Internal Medicine, Faculty of Medicine, Masaryk University and St. Anne'S University Hospital, Brno, Czech Republic $7 xx0274031
- 700 1_
- $a Kruzliak, Peter $u Research and Development Services, Brno, Czech Republic. peter.kruzliak@savba.sk
- 700 1_
- $a Plank, Lukas $u Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia $u Department of Pathological Anatomy, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
- 700 1_
- $a Lasabova, Zora $u Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia. zora.lasabova@uniba.sk $u Department of Molecular Biology and Genomics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia. zora.lasabova@uniba.sk
- 773 0_
- $w MED00009972 $t Journal of cancer research and clinical oncology $x 1432-1335 $g Roč. 147, č. 4 (2021), s. 1203-1215
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33044628 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20210420 $b ABA008
- 991 __
- $a 20220617104456 $b ABA008
- 999 __
- $a ok $b bmc $g 1649948 $s 1131788
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 147 $c 4 $d 1203-1215 $e 20201012 $i 1432-1335 $m Journal of cancer research and clinical oncology $n J Cancer Res Clin Oncol $x MED00009972
- GRA __
- $a VEGA-1/0380/18 $p Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
- LZP __
- $a Pubmed-20210420
