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Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential

P. Martín Moyano, V. Němec, K. Paruch

. 2020 ; 21 (20) : . [pub] 20201013

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc21012036

Grantová podpora
CZ.02.1.01/0.0/0.0/16_025/0007381 European Structural and Investment Funds, Operational Programme Research, Development and Education

Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM08502, entered clinical trials only recently. This review summarizes the biological roles and therapeutic potential of CLKs and their heretofore published small-molecule inhibitors, with a focus on the compounds' potential to be utilized as quality chemical biology probes.

Citace poskytuje Crossref.org

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