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Overcoming Waning Immunity in Pertussis Vaccines: Workshop of the National Institute of Allergy and Infectious Diseases

FH. Damron, M. Barbier, P. Dubey, KM. Edwards, XX. Gu, NP. Klein, K. Lu, KHG. Mills, MF. Pasetti, RC. Read, P. Rohani, P. Sebo, ET. Harvill

. 2020 ; 205 (4) : 877-882. [pub] 20200815

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc21012263

Grantová podpora
R01 AI137155 NIAID NIH HHS - United States
MR/N026993/1 Medical Research Council - United Kingdom
R21 AI116186 NIAID NIH HHS - United States
MR/N013204/1 Medical Research Council - United Kingdom
R56 AI107016 NIAID NIH HHS - United States
R01 GM113681 NIGMS NIH HHS - United States
R21 AI142678 NIAID NIH HHS - United States
R01 GM083113 NIGMS NIH HHS - United States
R56 AI065507 NIAID NIH HHS - United States

Despite high vaccine coverage in many parts of the world, pertussis is resurging in a number of areas in which acellular vaccines are the primary vaccine administered to infants and young children. This is attributed in part to the suboptimal and short-lived immunity elicited by acellular pertussis vaccines and to their inability to prevent nasal colonization and transmission of the etiologic agent Bordetella pertussis In response to this escalating public health concern, the National Institute of Allergy and Infectious Diseases held the workshop "Overcoming Waning Immunity in Pertussis Vaccines" in September 2019 to identify issues and possible solutions for the defects in immunity stimulated by acellular pertussis vaccines. Discussions covered aspects of the current problem, gaps in knowledge and possible paths forward. This review summarizes presentations and discussions of some of the key points that were raised by the workshop.

Citace poskytuje Crossref.org

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