• Je něco špatně v tomto záznamu ?

International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia

A. Condoluci, L. Terzi di Bergamo, P. Langerbeins, MA. Hoechstetter, CD. Herling, L. De Paoli, J. Delgado, KG. Rabe, M. Gentile, M. Doubek, FR. Mauro, G. Chiodin, M. Mattsson, J. Bahlo, G. Cutrona, J. Kotaskova, C. Deambrogi, KE. Smedby, V....

. 2020 ; 135 (21) : 1859-1869. [pub] 20200521

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, multicentrická studie, pozorovací studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21012571

Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an international prognostic score to predict time to first treatment (TTFT) in patients with CLL with early, asymptomatic disease (International Prognostic Score for Early-stage CLL [IPS-E]). Individual patient data from 11 international cohorts of patients with early-stage CLL (n = 4933) were analyzed to build and validate the prognostic score. Three covariates were consistently and independently correlated with TTFT: unmutated immunoglobulin heavy variable gene (IGHV), absolute lymphocyte count higher than 15 × 109/L, and presence of palpable lymph nodes. The IPS-E was the sum of the covariates (1 point each), and separated low-risk (score 0), intermediate-risk (score 1), and high-risk (score 2-3) patients showing a distinct TTFT. The score accuracy was validated in 9 cohorts staged by the Binet system and 1 cohort staged by the Rai system. The C-index was 0.74 in the training series and 0.70 in the aggregate of validation series. By meta-analysis of the training and validation cohorts, the 5-year cumulative risk for treatment start was 8.4%, 28.4%, and 61.2% among low-risk, intermediate-risk, and high-risk patients, respectively. The IPS-E is a simple and robust prognostic model that predicts the likelihood of treatment requirement in patients with early-stage CLL. The IPS-E can be useful in clinical management and in the design of early intervention clinical trials.

Augusta Victoria Hospital Jerusalem Israel

Azienda Ospedaliera of Cosenza Cosenza Italy

Biotechnology Research Unit Aprigliano Cosenza Italy

Cancer Sciences Division University of Southampton Southampton United Kingdom

Center of Integrated Oncology Cologne Bonn and German CLL Study Group University of Cologne Cologne Germany

Central European Institute of Technology Masaryk University Brno Czech Republic

Department of Experimental Medicine University of Genoa Genoa Italy

Department of Internal Medicine 3 University Hospital of Ulm Ulm Germany

Department of Oncology and Hemato Oncology University of Milan Milan Italy

Division of Hematology Department of Translational Medicine University of Eastern Piedmont Novara Italy

Division of Hematology Sapienza University Rome Italy

Hospital Clinic Barcelona Spain

Hospital Munich Schwabing German CLL Study Group Munich Germany

Institute of Hematology and Oncology University of Barcelona Barcelona Spain

Institute of Oncology Research Università della Svizzera Italiana Bellinzona Switzerland

Interní Hematologická a Onkologická Klinika University Hospital Brno and Medical Faculty Masaryk University Brno Czech Republic

IRCCS Ospedale Policlinico San Martino Genoa Italy

Karolinska Institute Stockholm Sweden

Mayo Clinic Rochester MN

Oncology Institute of Southern Switzerland Bellinzona Switzerland

Southampton University Hospital Trust Southampton United Kingdom

The 1st Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing China

University of Texas MD Anderson Cancer Center Houston TX

Uppsala University Hospital Uppsala Sweden

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21012571
003      
CZ-PrNML
005      
20240516084014.0
007      
ta
008      
210420s2020 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1182/blood.2019003453 $2 doi
035    __
$a (PubMed)32267500
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Condoluci, Adalgisa $u Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland $u Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
245    10
$a International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia / $c A. Condoluci, L. Terzi di Bergamo, P. Langerbeins, MA. Hoechstetter, CD. Herling, L. De Paoli, J. Delgado, KG. Rabe, M. Gentile, M. Doubek, FR. Mauro, G. Chiodin, M. Mattsson, J. Bahlo, G. Cutrona, J. Kotaskova, C. Deambrogi, KE. Smedby, V. Spina, A. Bruscaggin, W. Wu, R. Moia, E. Bianchi, B. Gerber, E. Zucca, S. Gillessen, M. Ghielmini, F. Cavalli, G. Stussi, MA. Hess, TS. Baumann, A. Neri, M. Ferrarini, R. Rosenquist, F. Forconi, R. Foà, S. Pospisilova, F. Morabito, S. Stilgenbauer, H. Döhner, SA. Parikh, WG. Wierda, E. Montserrat, G. Gaidano, M. Hallek, D. Rossi
520    9_
$a Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an international prognostic score to predict time to first treatment (TTFT) in patients with CLL with early, asymptomatic disease (International Prognostic Score for Early-stage CLL [IPS-E]). Individual patient data from 11 international cohorts of patients with early-stage CLL (n = 4933) were analyzed to build and validate the prognostic score. Three covariates were consistently and independently correlated with TTFT: unmutated immunoglobulin heavy variable gene (IGHV), absolute lymphocyte count higher than 15 × 109/L, and presence of palpable lymph nodes. The IPS-E was the sum of the covariates (1 point each), and separated low-risk (score 0), intermediate-risk (score 1), and high-risk (score 2-3) patients showing a distinct TTFT. The score accuracy was validated in 9 cohorts staged by the Binet system and 1 cohort staged by the Rai system. The C-index was 0.74 in the training series and 0.70 in the aggregate of validation series. By meta-analysis of the training and validation cohorts, the 5-year cumulative risk for treatment start was 8.4%, 28.4%, and 61.2% among low-risk, intermediate-risk, and high-risk patients, respectively. The IPS-E is a simple and robust prognostic model that predicts the likelihood of treatment requirement in patients with early-stage CLL. The IPS-E can be useful in clinical management and in the design of early intervention clinical trials.
650    _2
$a senioři $7 D000368
650    _2
$a nádorové biomarkery $x genetika $7 D014408
650    _2
$a klinické zkoušky jako téma $x statistika a číselné údaje $7 D002986
650    _2
$a kombinovaná terapie $7 D003131
650    _2
$a progrese nemoci $7 D018450
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a následné studie $7 D005500
650    _2
$a lidé $7 D006801
650    _2
$a chronická lymfatická leukemie $x genetika $x patologie $x terapie $7 D015451
650    _2
$a mužské pohlaví $7 D008297
650    12
$a mutace $7 D009154
650    12
$a nomogramy $7 D049451
650    _2
$a prognóza $7 D011379
650    _2
$a retrospektivní studie $7 D012189
650    _2
$a míra přežití $7 D015996
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
655    _2
$a pozorovací studie $7 D064888
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Terzi di Bergamo, Lodovico $u Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland
700    1_
$a Langerbeins, Petra $u Center of Integrated Oncology Cologne Bonn and German CLL Study Group, University of Cologne, Cologne, Germany
700    1_
$a Hoechstetter, Manuela A $u Hospital Munich-Schwabing, German CLL Study Group, Munich, Germany
700    1_
$a Herling, Carmen D $u Center of Integrated Oncology Cologne Bonn and German CLL Study Group, University of Cologne, Cologne, Germany
700    1_
$a De Paoli, Lorenzo $u Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
700    1_
$a Delgado, Julio $u Hospital Clinic, Barcelona, Spain
700    1_
$a Rabe, Kari G $u Mayo Clinic, Rochester, MN
700    1_
$a Gentile, Massimo $u Azienda Ospedaliera of Cosenza, Cosenza, Italy
700    1_
$a Doubek, Michael $u Interní Hematologická a Onkologická Klinika (IHOK), University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic $u Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Mauro, Francesca R $u Division of Hematology, Sapienza University, Rome, Italy
700    1_
$a Chiodin, Giorgia $u Cancer Sciences Division, University of Southampton, Southampton, United Kingdom
700    1_
$a Mattsson, Mattias $u Uppsala University Hospital, Uppsala, Sweden
700    1_
$a Bahlo, Jasmin $u Center of Integrated Oncology Cologne Bonn and German CLL Study Group, University of Cologne, Cologne, Germany
700    1_
$a Cutrona, Giovanna $u IRCCS Ospedale Policlinico San Martino, Genoa, Italy
700    1_
$a Kotaskova, Jana $u Interní Hematologická a Onkologická Klinika (IHOK), University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic $u Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Deambrogi, Clara $u Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
700    1_
$a Smedby, Karin E $u Karolinska Institute, Stockholm, Sweden
700    1_
$a Spina, Valeria $u Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland
700    1_
$a Bruscaggin, Alessio $u Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland
700    1_
$a Wu, Wei $u Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland $u The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
700    1_
$a Moia, Riccardo $u Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
700    1_
$a Bianchi, Elena $u Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
700    1_
$a Gerber, Bernhard $u Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
700    1_
$a Zucca, Emanuele $u Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
700    1_
$a Gillessen, Silke $u Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
700    1_
$a Ghielmini, Michele $u Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
700    1_
$a Cavalli, Franco $u Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
700    1_
$a Stussi, Georg $u Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
700    1_
$a Hess, Mark A $u University of Texas MD Anderson Cancer Center, Houston, TX
700    1_
$a Baumann, Tycho S $u Hospital Clinic, Barcelona, Spain
700    1_
$a Neri, Antonino $u Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
700    1_
$a Ferrarini, Manlio $u Department of Experimental Medicine, University of Genoa, Genoa, Italy
700    1_
$a Rosenquist, Richard $u Karolinska Institute, Stockholm, Sweden
700    1_
$a Forconi, Francesco $u Cancer Sciences Division, University of Southampton, Southampton, United Kingdom $u Southampton University Hospital Trust, Southampton, United Kingdom
700    1_
$a Foa, Robin $u Division of Hematology, Sapienza University, Rome, Italy $7 xx0317383
700    1_
$a Pospisilova, Sarka $u Interní Hematologická a Onkologická Klinika (IHOK), University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic $u Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Morabito, Fortunato $u Biotechnology Research Unit Aprigliano, Cosenza, Italy $u Augusta Victoria Hospital, Jerusalem, Israel
700    1_
$a Stilgenbauer, Stephan $u Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany; and
700    1_
$a Döhner, Hartmut $u Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany; and
700    1_
$a Parikh, Sameer A $u Mayo Clinic, Rochester, MN
700    1_
$a Wierda, William G $u University of Texas MD Anderson Cancer Center, Houston, TX
700    1_
$a Montserrat, Emili $u Hospital Clinic, Barcelona, Spain $u Institute of Hematology and Oncology, University of Barcelona, Barcelona, Spain
700    1_
$a Gaidano, Gianluca $u Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
700    1_
$a Hallek, Michael $u Center of Integrated Oncology Cologne Bonn and German CLL Study Group, University of Cologne, Cologne, Germany
700    1_
$a Rossi, Davide $u Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland $u Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
773    0_
$w MED00000807 $t Blood $x 1528-0020 $g Roč. 135, č. 21 (2020), s. 1859-1869
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32267500 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210420 $b ABA008
991    __
$a 20240516084008 $b ABA008
999    __
$a ok $b bmc $g 1650856 $s 1132950
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 135 $c 21 $d 1859-1869 $e 20200521 $i 1528-0020 $m Blood $n Blood $x MED00000807
LZP    __
$a Pubmed-20210420

Najít záznam

Citační ukazatele

Možnosti archivace