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Could 5'-N and S ProTide analogues work as prodrugs of antiviral agents

E. Procházková, H. Hřebabecký, M. Dejmek, M. Šála, M. Šmídková, E. Tloušťová, E. Zborníková, L. Eyer, D. Růžek, R. Nencka

. 2020 ; 30 (4) : 126897. [pub] 20191217

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21012861

Grantová podpora
NV16-34238A MZ0 CEP - Centrální evidence projektů

The nucleoside/nucleotide derived antiviral agents have been the most important components of antiviral therapy used in clinics. Recently, the focus of the medicinal chemists within this exciting research field has been affected mainly by the lack of effective therapies for the Hepatitis C virus (HCV) infection and several other "neglected" diseases caused by viruses such as Zika or Dengue. 2'-Methyl modified nucleosides and their monophosphate prodrugs (ProTides) have revolutionized the therapies for HCV in the last few years and, according to the latest research efforts, have also brought a promise for treatment of diseases caused by other members of Flaviviridae family. Here, we report on the design and synthesis of 5'-N and S modified ProTides derived from 2'-methyladenosine. We studied potential applicability of these derivatives as prodrugs of this archetypal antiviral compound.

Citace poskytuje Crossref.org

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