Could 5'-N and S ProTide analogues work as prodrugs of antiviral agents?
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
31882298
DOI
10.1016/j.bmcl.2019.126897
PII: S0960-894X(19)30875-3
Knihovny.cz E-resources
- Keywords
- (31)P NMR spectroscopy, Antiviral, HCV, Nucleotide, ProTide, Prodrug,
- MeSH
- Adenosine analogs & derivatives chemistry MeSH
- Antiviral Agents chemical synthesis chemistry pharmacology MeSH
- Nitrogen chemistry MeSH
- Hepacivirus drug effects MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy MeSH
- Nucleotides chemistry metabolism pharmacology MeSH
- Prodrugs chemical synthesis chemistry pharmacology MeSH
- Sulfur chemistry MeSH
- Dengue Virus drug effects MeSH
- Zika Virus drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 2-methyladenosine MeSH Browser
- Adenosine MeSH
- Antiviral Agents MeSH
- Nitrogen MeSH
- Nucleotides MeSH
- Prodrugs MeSH
- Sulfur MeSH
The nucleoside/nucleotide derived antiviral agents have been the most important components of antiviral therapy used in clinics. Recently, the focus of the medicinal chemists within this exciting research field has been affected mainly by the lack of effective therapies for the Hepatitis C virus (HCV) infection and several other "neglected" diseases caused by viruses such as Zika or Dengue. 2'-Methyl modified nucleosides and their monophosphate prodrugs (ProTides) have revolutionized the therapies for HCV in the last few years and, according to the latest research efforts, have also brought a promise for treatment of diseases caused by other members of Flaviviridae family. Here, we report on the design and synthesis of 5'-N and S modified ProTides derived from 2'-methyladenosine. We studied potential applicability of these derivatives as prodrugs of this archetypal antiviral compound.
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