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Real-life Effectiveness of Afatinib Versus Gefitinib in Patients With Non-small-cell Lung Cancer: A Czech Multicentre Study

M. Svaton, M. Bratova, O. Fischer, J. Krejci, L. Koubkova, M. Cernovska, M. Hrnciarik, M. Zemanova, H. Coupkova, B. Porzer, D. Dolezal, T. Tuzova, K. Hurdalkova, M. Barinova, J. Skrickova

. 2021 ; 41 (4) : 2059-2065. [pub] -

Language English Country Greece

Document type Journal Article, Multicenter Study

Persistent link   https://www.medvik.cz/link/bmc21018890

BACKGROUND/AIM: We investigated efficacy differences for afatinib versus gefitinib in non-small-cell lung cancer (NSCLC) according to epidermal growth factor receptor (EGFR) mutations. PATIENTS AND METHODS: We retrospectively analysed data for 343 patients with NSCLC with performance status 1 having EGFR mutations treated with gefitinib or afatinib. Overall response rate (ORR) was tested by Fisher's exact test. Overall (OS) and progression-free (PFS) survival were estimated by Kaplan-Meier method. RESULTS: ORR did not differ in any group or subgroup. Among all patients, we observed significantly longer PFS for those treated with afatinib vs. gefitinib (median 13.4 vs. 9.5 months, p=0.026), but only a nonsignificant trend was observed for OS. We showed nonsignificant trends of better PFS and OS using afatinib for exon 19 deletion and L858R subgroups. We observed no significant PFS differences for other EGFR mutations but a nonsignificant trend towards better OS for those treated with afatinib. CONCLUSION: Afatinib led to longer PFS for patients with common EGFR mutations but not for those with rare mutations.

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$a Svaton, Martin $u Department of Pneumology and Phthisiology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic; svatonm@fnplzen.cz
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$a BACKGROUND/AIM: We investigated efficacy differences for afatinib versus gefitinib in non-small-cell lung cancer (NSCLC) according to epidermal growth factor receptor (EGFR) mutations. PATIENTS AND METHODS: We retrospectively analysed data for 343 patients with NSCLC with performance status 1 having EGFR mutations treated with gefitinib or afatinib. Overall response rate (ORR) was tested by Fisher's exact test. Overall (OS) and progression-free (PFS) survival were estimated by Kaplan-Meier method. RESULTS: ORR did not differ in any group or subgroup. Among all patients, we observed significantly longer PFS for those treated with afatinib vs. gefitinib (median 13.4 vs. 9.5 months, p=0.026), but only a nonsignificant trend was observed for OS. We showed nonsignificant trends of better PFS and OS using afatinib for exon 19 deletion and L858R subgroups. We observed no significant PFS differences for other EGFR mutations but a nonsignificant trend towards better OS for those treated with afatinib. CONCLUSION: Afatinib led to longer PFS for patients with common EGFR mutations but not for those with rare mutations.
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$a Bratova, Monika $u Department of Respiratory Diseases, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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$a Fischer, Ondrej $u Department of Respiratory Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic
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$a Krejci, Jana $u Department of Pneumology and Thoracic Surgery, Bulovka Hospital, Prague, Czech Republic
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$a Koubkova, Leona $u Department of Pneumology, 2 Faculty of Medicine, Charles University, Prague, Czech Republic
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$a Cernovska, Marketa $u Department of Respiratory Medicine, Thomayer Hospital, Prague, Czech Republic
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$a Hrnciarik, Michal $u Department of Pneumology, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic
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$a Zemanova, Milada $u Department of Oncology, 1 Faculty of Medicine, Charles University, Prague, Czech Republic
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$a Coupkova, Helena $u Clinic of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
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$a Porzer, Bedrich $u Department of Respiratory Medicine and Tuberculosis, Medical faculty, Ostrava University, Ostrava, Czech Republic
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$a Dolezal, Daniel $u Department of Pneumology, Masaryk Hospital Usti nad Labem, Usti nad Labem, Czech Republic
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$a Tuzova, Tana $u Department of Oncology, Jihlava Hospital, Jihlava, Czech Republic
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$a Hurdalkova, Karolina $u Institute of Biostatistics and Analyses, Ltd., Brno, Czech Republic
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$a Barinova, Magda $u Institute of Biostatistics and Analyses, Ltd., Brno, Czech Republic
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$a Skrickova, Jana $u Department of Respiratory Diseases, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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