Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Incidence and severity of pertussis hospitalisations in infants aged less than 1 year in 37 hospitals of six EU/EEA countries, results of PERTINENT sentinel pilot surveillance system, December 2015 to December 2018

L. Merdrignac, F. Aït El Belghiti, E. Pandolfi, M. Jané, J. Murphy, K. Fabiánová, M. García Cenoz, E. Flem, S. Guillot, AE. Tozzi, G. Carmona, A. Habington, J. Zavadilová, A. Navasués, H. Bøås, D. Lévy-Brühl, B. Ferretti, M. Lanaspa, N....

. 2021 ; 26 (4) : . [pub] -

Language English Country Sweden

Document type Case Reports, Journal Article, Observational Study

Persistent link   https://www.medvik.cz/link/bmc21019532

IntroductionPERTINENT is a pilot active surveillance system of infants hospitalised with pertussis in six European Union/European Economic Area countries (37 hospitals, seven sites).AimThis observational study aimed to estimate annual pertussis incidence per site from 2016 to 2018 and respective trends between 2017 and 2018. Pertussis cases were described, including their severity.MethodsWe developed a generic protocol and laboratory guidelines to harmonise practices across sites. Cases were hospitalised infants testing positive for Bordetella pertussis by PCR or culture. Sites collected demographic, clinical, laboratory data, vaccination status, and risk/protective factors. We estimated sites' annual incidences by dividing case numbers by the catchment populations.ResultsFrom December 2015 to December 2018, we identified 469 cases (247 males; 53%). The median age, birthweight and gestational age were 2.5 months (range: 0-11.6; interquartile range (IQR): 2.5), 3,280 g (range: 700-4,925; IQR: 720) and 39 weeks (range: 25-42; IQR: 2), respectively. Thirty cases (6%) had atypical presentation either with cough or cyanosis only or with absence of pertussis-like symptoms. Of 330 cases with information, 83 (25%) were admitted to intensive care units including five deceased infants too young to be vaccinated. Incidence rate ratios between 2018 and 2017 were 1.43 in Czech Republic (p = 0.468), 0.25 in Catalonia (p = 0.002), 0.71 in France (p = 0.034), 0.14 in Ireland (p = 0.002), 0.63 in Italy (p = 0.053), 0.21 in Navarra (p = 0.148) and zero in Norway.ConclusionsIncidence appeared to decrease between 2017 and 2018 in all but one site. Enhanced surveillance of hospitalised pertussis in Europe is essential to monitor pertussis epidemiology and disease burden.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21019532
003      
CZ-PrNML
005      
20210830101124.0
007      
ta
008      
210728s2021 sw f 000 0|eng||
009      
AR
024    7_
$a 10.2807/1560-7917.ES.2021.26.4.1900762 $2 doi
035    __
$a (PubMed)33509338
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sw
100    1_
$a Merdrignac, Lore $u Epidemiology Department, Epiconcept, Paris, France
245    10
$a Incidence and severity of pertussis hospitalisations in infants aged less than 1 year in 37 hospitals of six EU/EEA countries, results of PERTINENT sentinel pilot surveillance system, December 2015 to December 2018 / $c L. Merdrignac, F. Aït El Belghiti, E. Pandolfi, M. Jané, J. Murphy, K. Fabiánová, M. García Cenoz, E. Flem, S. Guillot, AE. Tozzi, G. Carmona, A. Habington, J. Zavadilová, A. Navasués, H. Bøås, D. Lévy-Brühl, B. Ferretti, M. Lanaspa, N. O'Sullivan, P. Křížová, L. Fernandino, T. Bekkevold, T. Hanslik, C. Muñoz-Almagro, S. Bacci, G. Spiteri, M. Valenciano, A. Moren, PERTINENT Group, PERTINENT group
520    9_
$a IntroductionPERTINENT is a pilot active surveillance system of infants hospitalised with pertussis in six European Union/European Economic Area countries (37 hospitals, seven sites).AimThis observational study aimed to estimate annual pertussis incidence per site from 2016 to 2018 and respective trends between 2017 and 2018. Pertussis cases were described, including their severity.MethodsWe developed a generic protocol and laboratory guidelines to harmonise practices across sites. Cases were hospitalised infants testing positive for Bordetella pertussis by PCR or culture. Sites collected demographic, clinical, laboratory data, vaccination status, and risk/protective factors. We estimated sites' annual incidences by dividing case numbers by the catchment populations.ResultsFrom December 2015 to December 2018, we identified 469 cases (247 males; 53%). The median age, birthweight and gestational age were 2.5 months (range: 0-11.6; interquartile range (IQR): 2.5), 3,280 g (range: 700-4,925; IQR: 720) and 39 weeks (range: 25-42; IQR: 2), respectively. Thirty cases (6%) had atypical presentation either with cough or cyanosis only or with absence of pertussis-like symptoms. Of 330 cases with information, 83 (25%) were admitted to intensive care units including five deceased infants too young to be vaccinated. Incidence rate ratios between 2018 and 2017 were 1.43 in Czech Republic (p = 0.468), 0.25 in Catalonia (p = 0.002), 0.71 in France (p = 0.034), 0.14 in Ireland (p = 0.002), 0.63 in Italy (p = 0.053), 0.21 in Navarra (p = 0.148) and zero in Norway.ConclusionsIncidence appeared to decrease between 2017 and 2018 in all but one site. Enhanced surveillance of hospitalised pertussis in Europe is essential to monitor pertussis epidemiology and disease burden.
650    _2
$a senioři $7 D000368
650    _2
$a Bordetella pertussis $7 D001886
650    _2
$a Evropská unie $7 D005062
650    _2
$a hospitalizace $7 D006760
650    _2
$a nemocnice $7 D006761
650    _2
$a lidé $7 D006801
650    _2
$a incidence $7 D015994
650    _2
$a kojenec $7 D007223
650    _2
$a novorozenec $7 D007231
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a pertusová vakcína $7 D010567
650    _2
$a vakcinace $7 D014611
650    12
$a pertuse $x diagnóza $x epidemiologie $x prevence a kontrola $7 D014917
651    _2
$a Česká republika $7 D018153
651    _2
$a Evropa $7 D005060
651    _2
$a Francie $7 D005602
651    _2
$a Irsko $7 D007494
651    _2
$a Itálie $7 D007558
651    _2
$a Norsko $7 D009664
655    _2
$a kazuistiky $7 D002363
655    _2
$a časopisecké články $7 D016428
655    _2
$a pozorovací studie $7 D064888
700    1_
$a Aït El Belghiti, Fatima $u Direction des maladies infectieuses, Santé Publique France, Paris, France
700    1_
$a Pandolfi, Elisabetta $u Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children Hospital, Rome, Italy
700    1_
$a Jané, Mireia $u Epidemiological surveillance and response, Public Health Agency of Catalonia, Barcelona, Spain
700    1_
$a Murphy, Jane $u Research, Temple Street Children's University Hospital, Dublin, Ireland
700    1_
$a Fabiánová, Kateřina $u National Institute of Public Health, Prague, Czech Republic
700    1_
$a García Cenoz, Manuel $u Instituto de Salud Pública de Navarra, IdiSNA - Navarre Institute for Health Research, Pamplona, Spain
700    1_
$a Flem, Elmira $u Infectious Disease Epidemiology and Modeling, Norwegian Institute of Public Health, Oslo, Norway
700    1_
$a Guillot, Sophie $u Biodiversité et Epidémiologie des bactéries et pathogènes, Institut Pasteur, Paris, France
700    1_
$a Tozzi, Alberto E $u Chief Innovation Unit and Clinical Trials, Bambino Gesù Children Hospital, Rome, Italy
700    1_
$a Carmona, Gloria $u Epidemiological surveillance and response, Public Health Agency of Catalonia, Barcelona, Spain
700    1_
$a Habington, Adele $u Microbiology, Our Lady's Children's hospital Crumlin, Dublin, Ireland
700    1_
$a Zavadilová, Jana $u National Institute of Public Health, Prague, Czech Republic
700    1_
$a Navasués, Ana $u Clinical Microbiology Service, Complejo Hospitalario de Navarra, Pamplona, Spain
700    1_
$a Bøås, Håkon $u Infectious Disease Epidemiology and Modeling, Norwegian Institute of Public Health, Oslo, Norway
700    1_
$a Lévy-Brühl, Daniel $u Direction des maladies infectieuses, Santé Publique France, Paris, France
700    1_
$a Ferretti, Beatrice $u Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children Hospital, Rome, Italy
700    1_
$a Lanaspa, Miguel $u Instituto de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, Spain
700    1_
$a O'Sullivan, Niam $u Microbiology, Our Lady's Children's hospital Crumlin, Dublin, Ireland
700    1_
$a Křížová, Pavla $u National Institute of Public Health, Prague, Czech Republic
700    1_
$a Fernandino, Leticia $u Instituto de Salud Pública de Navarra, IdiSNA - Navarre Institute for Health Research, Pamplona, Spain
700    1_
$a Bekkevold, Terese $u Infectious Disease Epidemiology and Modeling, Norwegian Institute of Public Health, Oslo, Norway
700    1_
$a Hanslik, Thomas $u Sorbonne University, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France
700    1_
$a Muñoz-Almagro, Carmen $u CIBER of Epidemiology and Public Health CIBERESP, Barcelona, Spain $u Universitat Internacional de Catalunya, Barcelona, Spain $u Instituto de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, Spain
700    1_
$a Bacci, Sabrina $u European Centre for Diseases Prevention and Control, Stockholm, Sweden
700    1_
$a Spiteri, Gianfranco $u European Centre for Diseases Prevention and Control, Stockholm, Sweden
700    1_
$a Valenciano, Marta $u Epidemiology Department, Epiconcept, Paris, France
700    1_
$a Moren, Alain $u Epidemiology Department, Epiconcept, Paris, France
710    2_
$a PERTINENT Group
710    2_
$a PERTINENT group
773    0_
$w MED00174364 $t Euro surveillance : bulletin Europeen sur les maladies transmissibles European communicable disease bulletin $x 1560-7917 $g Roč. 26, č. 4 (2021)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33509338 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830101124 $b ABA008
999    __
$a ok $b bmc $g 1690374 $s 1139978
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 26 $c 4 $e - $i 1560-7917 $m Euro surveillance $n Euro Surveill $x MED00174364
LZP    __
$a Pubmed-20210728

Find record

Citation metrics

Archiving options