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Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics

L. Skladaný, M. Oltman, S. Fraňková, S. Dražilová, P. Husa, J. Šperl, V. Hejda, P. Urbánek, S. Adamcová-Selčanová, M. Janičko, P. Kristian, V. Kupčová, M. Rác, I. Schréter, L. Virág, A. Liptáková, M. Ondrášová, P. Jarčuška

. 2020 ; 65 (9) : 1723-1735. [pub] 20201010

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, pozorovací studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc21019733

OBJECTIVES: The MOSAIC study gathered data on chronic hepatitis C virus (HCV) infection and its treatment in various countries worldwide. Here we summarise patient and HCV characteristics in the Czech Republic and Slovakia. METHODS: MOSAIC was an observational study that included patients with chronic HCV infection untreated at the time of enrolment. Study collected and descriptively analysed patient demographics, disease stage and viral characteristics. Data were collected between February 2014 to October 2014. RESULTS: Among 220 patients enrolled, 51.4% were treatment-naïve. The most prevalent HCV genotype was G1 (78.4%), followed by G3 (19.7%). Higher prevalence of G1 was found in treatment-experienced patients (94.3%) compared to treatment-naïve (63.4%). Most participants (67.7%) presented viral RNA load of ≥ 800,000 IU/mL. Liver cirrhosis was reported in 24.5% of patients. Higher HCV RNA load and duration of HCV infection correlated with the degree of liver fibrosis. Anti-HCV interferon-based treatments were initiated in 88.2% of participants. CONCLUSIONS: The study confirmed significant changes in the HCV genotypes partition with G3 genotype rapidly increasing in both countries, with possible impact on the WHO eradication initiative and treatment selection.

Citace poskytuje Crossref.org

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$a Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics / $c L. Skladaný, M. Oltman, S. Fraňková, S. Dražilová, P. Husa, J. Šperl, V. Hejda, P. Urbánek, S. Adamcová-Selčanová, M. Janičko, P. Kristian, V. Kupčová, M. Rác, I. Schréter, L. Virág, A. Liptáková, M. Ondrášová, P. Jarčuška
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$a OBJECTIVES: The MOSAIC study gathered data on chronic hepatitis C virus (HCV) infection and its treatment in various countries worldwide. Here we summarise patient and HCV characteristics in the Czech Republic and Slovakia. METHODS: MOSAIC was an observational study that included patients with chronic HCV infection untreated at the time of enrolment. Study collected and descriptively analysed patient demographics, disease stage and viral characteristics. Data were collected between February 2014 to October 2014. RESULTS: Among 220 patients enrolled, 51.4% were treatment-naïve. The most prevalent HCV genotype was G1 (78.4%), followed by G3 (19.7%). Higher prevalence of G1 was found in treatment-experienced patients (94.3%) compared to treatment-naïve (63.4%). Most participants (67.7%) presented viral RNA load of ≥ 800,000 IU/mL. Liver cirrhosis was reported in 24.5% of patients. Higher HCV RNA load and duration of HCV infection correlated with the degree of liver fibrosis. Anti-HCV interferon-based treatments were initiated in 88.2% of participants. CONCLUSIONS: The study confirmed significant changes in the HCV genotypes partition with G3 genotype rapidly increasing in both countries, with possible impact on the WHO eradication initiative and treatment selection.
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$a Husa, Petr $u Clinic of Infectious Diseases, University Hospital Brno, Masaryk University, Brno, Czech Republic
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$a Šperl, Jan $u Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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$a Janičko, Martin $u 2nd Department of Internal Medicine, Faculty of Medicine, P.J. Safarik University and L. Pasteur University Hospital, Kosice, Slovakia
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$a Kupčová, Viera $u 3rd Department of Internal Medicine, Derer's Hospital, Bratislava, Slovakia
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$a Schréter, Ivan $u Department of Infectious Diseases, Faculty of Medicine, P.J. Safarik University and L. Pasteur University Hospital, Kosice, Slovakia
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$a Virág, Ladislav $u Department of Infectious Diseases, Faculty of Medicine, P.J. Safarik University and L. Pasteur University Hospital, Kosice, Slovakia
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$a Liptáková, Adriana $u Department of Microbiology, Faculty of Medicine and University Hospital, Commenius University, Bratislava, Slovakia
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