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Associations between high triglycerides and arterial stiffness in a population-based sample: Kardiovize Brno 2030 study
I. Pavlovska, S. Kunzova, J. Jakubik, J. Hruskova, M. Skladana, IM. Rivas-Serna, JR. Medina-Inojosa, F. Lopez-Jimenez, R. Vysoky, YE. Geda, GB. Stokin, JP. González-Rivas
Language English Country Great Britain
Document type Journal Article
Grant support
CZ.1.05/1.1.00/02.0123
European Regional Development Fund
LQ1605
National Program of Sustainability II (MEYS CR)
316345
7th Framework Program of the European Union
NT13434-4/2012
Ministerstvo Zdravotnictví Ceské Republiky
NLK
BioMedCentral
from 2002-12-01
BioMedCentral Open Access
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Directory of Open Access Journals
from 2002
Free Medical Journals
from 2002
PubMed Central
from 2002
Europe PubMed Central
from 2002
ProQuest Central
from 2009-01-01
Open Access Digital Library
from 2002-01-01
Open Access Digital Library
from 2002-09-01
Open Access Digital Library
from 2002-01-01
Medline Complete (EBSCOhost)
from 2002-09-03
Health & Medicine (ProQuest)
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ROAD: Directory of Open Access Scholarly Resources
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Springer Nature OA/Free Journals
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- MeSH
- Atherosclerosis blood physiopathology MeSH
- Adult MeSH
- Hypertriglyceridemia blood physiopathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Metabolic Syndrome blood physiopathology MeSH
- Regression Analysis MeSH
- Risk Factors MeSH
- Triglycerides blood MeSH
- Vascular Stiffness physiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: The term arterial stiffness (ArSt) describes structural changes in arterial wall related to the loss of elasticity and is known as an independent predictor of cardiovascular diseases (CVD). The evidence relating to ArSt and triglycerides (TG) shows contradictory results. This paper means to survey the association between high TG and ArSt, utilizing the cardio-ankle vascular index (CAVI). METHODS: Subjects aged between 25 and 64 years from a random population-based sample were evaluated between 2013 and 2016. Data from questionnaires, blood pressure, anthropometric measures, and blood samples were collected and analyzed. CAVI was measured using VaSera VS-1500 N devise. Subjects with a history of CVD or chronic renal disease were excluded. RESULTS: One thousand nine hundred thirty-four participants, 44.7% of males, were included. The median age was 48 (Interquartile Range [IQR] 19) years, TG levels were 1.05 (0.793) mmol/L, and CAVI 7.24 (1.43) points. Prevalence of high CAVI was 10.0% (14.5% in males and 6.4% in females; P < 0.001) and prevalence of hypertriglyceridemia was 20.2% (29.2% in males and 13% in females, P < 0.001). The correlation between TG and CAVI was 0.136 (P < 0.001). High CAVI values were more prevalent among participants with metabolic syndrome (MetS), high blood pressure, dysglycemia, abdominal obesity, high LDL-cholesterol (LDL-c), and high total cholesterol. Using binary regression analysis, high TG were associated with high CAVI, even after adjustment for other MetS components, age, gender, smoking status, LDL-c, and statin treatment (β = 0.474, OR = 1.607, 95% CI = 1.063-2.429, P = 0.024). CONCLUSION: TG levels were correlated with ArSt, measured as CAVI. High TG was associated with high CAVI independent of multiple cardiometabolic risk factors. Awareness of the risks and targeted treatment of hypertriglyceridemia could further benefit in reducing the prevalence of CVD and events.
Department of Global Health and Population | Harvard T H Chan School of Public Health Boston USA
Department of Neurology Barrow Neurological Institute Phoenix USA
Department of Public Health Faculty of Medicine Masaryk University Brno Czech Republic
Division of Preventive Cardiology Department of Cardiovascular Medicine Mayo Clinic Rochester MN USA
References provided by Crossref.org
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