- MeSH
- diabetes mellitus 2. typu farmakoterapie patofyziologie prevence a kontrola MeSH
- hodnocení rizik metody normy MeSH
- hypertenze farmakoterapie patofyziologie prevence a kontrola MeSH
- hypertriglyceridemie farmakoterapie patofyziologie prevence a kontrola MeSH
- lidé MeSH
- rizikové faktory kardiovaskulárních chorob * MeSH
- zdravé chování klasifikace MeSH
- zdravotně rizikové chování klasifikace MeSH
- zohlednění rizika metody normy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
BACKGROUND: The term arterial stiffness (ArSt) describes structural changes in arterial wall related to the loss of elasticity and is known as an independent predictor of cardiovascular diseases (CVD). The evidence relating to ArSt and triglycerides (TG) shows contradictory results. This paper means to survey the association between high TG and ArSt, utilizing the cardio-ankle vascular index (CAVI). METHODS: Subjects aged between 25 and 64 years from a random population-based sample were evaluated between 2013 and 2016. Data from questionnaires, blood pressure, anthropometric measures, and blood samples were collected and analyzed. CAVI was measured using VaSera VS-1500 N devise. Subjects with a history of CVD or chronic renal disease were excluded. RESULTS: One thousand nine hundred thirty-four participants, 44.7% of males, were included. The median age was 48 (Interquartile Range [IQR] 19) years, TG levels were 1.05 (0.793) mmol/L, and CAVI 7.24 (1.43) points. Prevalence of high CAVI was 10.0% (14.5% in males and 6.4% in females; P < 0.001) and prevalence of hypertriglyceridemia was 20.2% (29.2% in males and 13% in females, P < 0.001). The correlation between TG and CAVI was 0.136 (P < 0.001). High CAVI values were more prevalent among participants with metabolic syndrome (MetS), high blood pressure, dysglycemia, abdominal obesity, high LDL-cholesterol (LDL-c), and high total cholesterol. Using binary regression analysis, high TG were associated with high CAVI, even after adjustment for other MetS components, age, gender, smoking status, LDL-c, and statin treatment (β = 0.474, OR = 1.607, 95% CI = 1.063-2.429, P = 0.024). CONCLUSION: TG levels were correlated with ArSt, measured as CAVI. High TG was associated with high CAVI independent of multiple cardiometabolic risk factors. Awareness of the risks and targeted treatment of hypertriglyceridemia could further benefit in reducing the prevalence of CVD and events.
- MeSH
- ateroskleróza krev patofyziologie MeSH
- dospělí MeSH
- hypertriglyceridemie krev patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- metabolický syndrom krev patofyziologie MeSH
- regresní analýza MeSH
- rizikové faktory MeSH
- triglyceridy krev MeSH
- tuhost cévní stěny fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Reactive dicarbonyls stimulate production of advanced glycation endproducts, increase oxidative stress and inflammation and contribute to the development of vascular complications. We measured concentrations of dicarbonyls - methylglyoxal (MG), glyoxal (GL) and 3-deoxyglucosone (3-DG) - in the heart and kidney of a model of metabolic syndrome - hereditary hypertriglyceridemic rats (HHTg) and explored its modulation by metformin. Adult HHTg rats were fed a standard diet with or without metformin (300 mg/kg b.w.) and dicarbonyl levels and metabolic parameters were measured. HHTg rats had markedly elevated serum levels of triacylglycerols (p<0.001), FFA (p<0.01) and hepatic triacylglycerols (p<0.001) along with increased concentrations of reactive dicarbonyls in myocardium (MG: p<0.001; GL: p<0.01; 3-DG: p<0.01) and kidney cortex (MG: p<0.01). Metformin treatment significantly reduced reactive dicarbonyls in the myocardium (MG: p<0.05, GL: p<0.05, 3-DG: p<0.01) along with increase of myocardial concentrations of reduced glutathione (p<0.01) and glyoxalase 1 mRNA expression (p<0.05). Metformin did not have any significant effect on dicarbonyls, glutathione or on glyoxalase 1 expression in kidney cortex. Chronically elevated hypertriglyceridemia was associated with increased levels of dicarbonyls in heart and kidney. Beneficial effects of metformin on reactive dicarbonyls and glyoxalase in the heart could contribute to its cardioprotective effects.
- MeSH
- deoxyglukosa analogy a deriváty metabolismus MeSH
- dieta MeSH
- fyziologický stres MeSH
- glutathion metabolismus MeSH
- glyoxal metabolismus MeSH
- hypertriglyceridemie farmakoterapie genetika patofyziologie MeSH
- hypoglykemika terapeutické užití MeSH
- krysa rodu rattus MeSH
- laktoylglutathionlyasa metabolismus MeSH
- metformin terapeutické užití MeSH
- myokard metabolismus MeSH
- potkani Wistar MeSH
- pyruvaldehyd metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- mipomersen,
- MeSH
- antagonisté kanabinoidních receptorů farmakologie škodlivé účinky terapeutické užití MeSH
- anticholesteremika MeSH
- diabetes mellitus 2. typu MeSH
- dieta s omezením tuků MeSH
- distribuce tělesného tuku MeSH
- dyslipidemie * etiologie patofyziologie MeSH
- HDL-cholesterol krev metabolismus normy MeSH
- hypertriglyceridemie dietoterapie farmakoterapie klasifikace patofyziologie MeSH
- hypolipidemika farmakokinetika terapeutické užití MeSH
- inzulinová rezistence MeSH
- látky regulující metabolismus lipidů MeSH
- LDL-cholesterol normy účinky léků MeSH
- lidé MeSH
- metabolický syndrom MeSH
- obezita komplikace MeSH
- PCSK9 inhibitory MeSH
- proproteinkonvertasa subtilisin/kexin typu 9 MeSH
- zánět patofyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- hodnocení rizik MeSH
- hypertriglyceridemie krev patofyziologie prevence a kontrola MeSH
- kardiovaskulární nemoci * metabolismus patofyziologie epidemiologie metabolismus patofyziologie MeSH
- lidé MeSH
- triglyceridy krev normy škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
Several authors have reported the association of postprandial hypertriglyceridemia with oxidative stress, systemic inflammation and endothelial dysfunction. Our aim was to investigate the effect of high-calorie meal on blood markers of oxidative stress and endothelial dysfunction and the association of APOA5 -1131T/C and -250G/A hepatic lipase (HL) polymorphisms with postprandial triglyceride response. This study included 102 healthy male volunteers. All participants consumed a high-calorie meal (823 calories, 50 g fat, 28 g protein, 60 g carbohydrates). Total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, hsCRP, TAS and ICAM-1 were measured at fasting state and postprandially. APOA5 -1131T/C and -250G/A HL polymorphisms were also determined. Postprandial triglycerides were significantly increased (1.4 (1.1-2.1) vs. 2.4 (1.9-3.3) mmol/l, P<0.001). Average triglyceride increase was 1.0+/-0.7 mmol/l (65 %). Concentration of triglycerides, HDL-cholesterol, LDL-cholesterol, TAS and ICAM-1 differed significantly between the fasting state and postprandial measurements (P<0.001). However, those differences were within the limits of analytical imprecision. Other parameters did not change 3 h after the meal. Triglycerides response did not differ respective to the APOA5 and HL polymorphisms. Family history of hypertension and acute myocardial infarction were associated with higher postprandial triglyceride concentrations. Postprandial hypertriglyceridemia is not associated with increased concentrations of hsCRP, TAS and ICAM-1. Furthermore, APOA5 -1131T/C and -250G/A HL polymorphisms are not associated with different postprandial triglyceride response.
- MeSH
- apolipoproteiny A genetika MeSH
- cévní endotel patofyziologie MeSH
- dietní tuky metabolismus MeSH
- dospělí MeSH
- energetický příjem MeSH
- hypertriglyceridemie patofyziologie MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- oxidační stres * MeSH
- postprandiální období * MeSH
- referenční hodnoty MeSH
- senioři MeSH
- triglyceridy krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Je obecně známým a akceptovaným faktem, že v pozadí pandemie kardiovaskulárních onemocnění (KVO) stojí ateroskleróza. Při její predikci, profylaxii úspěšné léčbě musíme především identifikovat její nejrůznější rizikové faktory (RF). Do současnosti byly identifikovány řádově stovky RF, nicméně váha různých RF se liší. Hlavními RF jsou stále zvýšené koncentrace celkového a LDL cholesterolu a aterogenní dyslipidémie (AD) charakterizovaná zvýšenou koncentrací triglyceridů (TG) a nízkou koncentrací HDL cholesterolu. Kromě těchto zásadních rizik se v článku budeme věnovat lipoproteinu(a), fosfolipáze asociované s lipoproteiny (Lp-PLA2), jejíž zvýšené koncentrace jsou spojeny s destabilizací aterosklerotického plátu. Část tohoto sdělení bude věnována postprandiální lipidémii.
- Klíčová slova
- stabilní a nestabilní plát, Lp(a), Lp-PLA2, aterogenní dyslipidémie, fibráty,
- MeSH
- 1-alkyl-2-acetylglycerofosfocholinesterasa krev MeSH
- ateroskleróza diagnóza patofyziologie prevence a kontrola MeSH
- dyslipidemie komplikace MeSH
- financování organizované MeSH
- fosfolipasy krev MeSH
- HDL-cholesterol krev MeSH
- hyperlipoproteinemie patofyziologie MeSH
- hypertriglyceridemie komplikace patofyziologie MeSH
- LDL-cholesterol krev MeSH
- lidé MeSH
- lipoprotein (a) krev MeSH
- niacin MeSH
- rizikové faktory MeSH
- statiny škodlivé účinky terapeutické užití MeSH
- triglyceridy krev MeSH
- Check Tag
- lidé MeSH
BACKGROUND: High-sensitivity C-reactive protein is an important biomarker of systemic inflammation. We studied the contribution to cardiovascular risk of increased high-sensitivity C-reactive protein in patients with type 2 diabetes with or without concomitant metabolic syndrome. MATERIAL/METHODS: The series included 381 patients (199 men, 182 women; median age, 66 years; age range, 50-80 years) with a mean duration of type 2 diabetes of 9+/-8 years. Standard physical examinations and laboratory investigations were administered to all patients. Modified National Cholesterol Education Program III criteria for defining the metabolic syndrome were used. High-sensitivity C-reactive protein was estimated by immunoturbidimetry and other laboratory tests using standard methods. RESULTS: High-sensitivity C-reactive protein correlated (Spearman's correlation) significantly positively with body mass index and waist size, fasting plasma triglyceride levels, apolipoprotein-B, gamma glutamyl transferase, homeostasis model assessment of insulin resistance, and fibrinogen, and negatively with high-density lipoprotein cholesterol. However, only waist, fibrinogen, apolipoprotein-B, plasma glucose, and gamma glutamyl transferase levels appeared to be associated with high-sensitivity C-reactive protein on multiple logistic regression model analyses. In those diabetic patients with concomitant metabolic syndrome, the hypertriglyceridemic waist appeared to be a major factor for an increased high-sensitivity C-reactive protein concentration. CONCLUSIONS: The hypertriglyceridemic waist contributes to the metabolic syndrome and most likely is an important factor increasing high-sensitivity C-reactive protein levels and consequently, relative coronary risk in patients with type 2 diabetes of any sex and age. PMID:18667998[PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, SubstancesPublication TypesResearch Support, Non-U.S. Gov'tMeSH TermsAge DistributionAgedAged, 80 and overC-Reactive Protein/analysis*Diabetes Mellitus, Type 2/blood*Diabetes Mellitus, Type 2/complications*Diabetes Mellitus, Type 2/physiopathologyFemaleHumansHypertriglyceridemia/bloodHypertriglyceridemia/complicationsHypertriglyceridemia/physiopathology*MaleMetabolic Syndrome X/blood*Metabolic Syndrome X/complications*Metabolic Syndrome X/physiopathologyMiddle AgedStatistics, NonparametricWaist-Hip Ratio*SubstancesC-Reactive Protein LinkOut - more resourcesFull Text SourcesMedical Science International, Ltd. - PDFMedicalTriglycerides - MedlinePlus Health InformationMetabolic Syndrome - MedlinePlus Health InformationDiabetes - MedlinePlus Health Information • Supplemental Content Related citations [The prevalence of metabolic syndrome in middle-aged in Kaunas population]. [Medicina (Kaunas). 2005] [The prevalence of metabolic syndrome in middle-aged in Kaunas population]. Gustiene O, Slapikas R, Klumbiene J, Sakalauskiene G, Kubilius R, Bagdzeviciute S, Zaliunas R. Medicina (Kaunas). 2005; 41(10):867-76. The hypertriglyceridemic waist phenotype versus the National Cholesterol Education Program-Adult Treatment Panel III and International Diabetes Federation clinical criteria to identify high-risk men with an altered cardiometabolic risk profile. [Metabolism. 2009] The hypertriglyceridemic waist phenotype versus the National Cholesterol Education Program-Adult Treatment Panel III and International Diabetes Federation clinical criteria to identify high-risk men with an altered cardiometabolic risk profile. Blackburn P, Lemieux I, Alméras N, Bergeron J, Côté M, Tremblay A, Lamarche B, Després JP. Metabolism. 2009 Aug; 58(8):1123-30. Epub 2009 Jun 18.Meal testing and postprandial state of type 2 diabetic patients with metabolic syndrome. [Rom J Intern Med. 2005] Meal testing and postprandial state of type 2 diabetic patients with metabolic syndrome. Brădescu OM, Georgescu M, Ifrim S, Ioacără S, Ionescu-Tîrgovişte C. Rom J Intern Med. 2005; 43(1-2):97-113. Review Hypertriglyceridemic waist: a useful screening phenotype in preventive cardiology? [Can J Cardiol. 2007] Review Hypertriglyceridemic waist: a useful screening phenotype in preventive cardiology? Lemieux I, Poirier P, Bergeron J, Alméras N, Lamarche B, Cantin B, Dagenais GR, Després JP. Can J Cardiol. 2007 Oct; 23 Suppl B:23B-31B. Review Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? [Circulation. 2004] Review Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? Ridker PM, Wilson PW, Grundy SM. Circulation. 2004 Jun 15; 109(23):2818-25. See reviews... See all... Cited by 1 PubMed Central article Effect of a fat spread enriched with medium-chain triacylglycerols and a special fatty acid-micronutrient combination on cardiometabolic risk factors in overweight patients with diabetes. [Nutr Metab (Lond). 2011] Effect of a fat spread enriched with medium-chain triacylglycerols and a special fatty acid-micronutrient combination on cardiometabolic risk factors in overweight patients with diabetes. Siener R, Ehrhardt C, Bitterlich N, Metzner C. Nutr Metab (Lond). 2011 Apr 8; 8:21. Epub 2011 Apr 8.All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.Gene Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.Gene (GeneRIF) Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.HomoloGene HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry
- MeSH
- C-reaktivní protein analýza MeSH
- diabetes mellitus 2. typu komplikace krev patofyziologie MeSH
- financování organizované MeSH
- hypertriglyceridemie komplikace krev patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- metabolický syndrom komplikace krev patofyziologie MeSH
- neparametrická statistika MeSH
- poměr pasu a boků MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- věkové rozložení MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
BACKGROUND/AIMS: The feeding artery of dialysis vascular access is subjected to unusually high wall shear stress (WSS), a hemodynamic factor leading to vasodilatation, for at least several months after access creation. Physiologically, high WSS leads to compensatory endothelium-dependent vasodilatation. We supposed that the dilatation of the feeding artery continues to lower WSS during longer time period after access creation and that this process is limited by risk factors of endothelial dysfunction. METHODS: We examined the feeding artery of vascular accesses within 3 months, 1 and 2 years after access creation. By ultrasonography, we obtained internal diameter and blood velocity in the feeding arteries. We calculated wall shear rate (WSR). RESULTS: We examined 75 patients. Internal diameter rose from 3.9 +/- 0.1 mm (3 months) to 4.3 +/- 0.2 mm within the first year and to 4.6 +/- 0.2 mm within the second. Similarly, mean WSR decreased from 1,839 +/- 117 to 1,629 +/- 123 s(-1) and to 1,159 +/- 109 s(-1), respectively. The vasodilatation was limited by diabetes mellitus, hypercholesterolemia and hypertriglyceridemia. CONCLUSIONS: The feeding artery continues to dilate 2 years after access creation, with a simultaneous decrease in WSR. This process is dampened in patients with diabetes mellitus and dyslipidemia
- MeSH
- arterie fyziologie ultrasonografie MeSH
- cévní endotel fyziologie MeSH
- diabetes mellitus patofyziologie MeSH
- dialýza ledvin MeSH
- duplexní dopplerovská ultrasonografie MeSH
- financování organizované MeSH
- fyziologická adaptace MeSH
- hypercholesterolemie patofyziologie MeSH
- hypertriglyceridemie patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- pevnost ve smyku MeSH
- senioři MeSH
- vazodilatace fyziologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
Metabolický syndrom je dnes, dvacet let od své první definice poměrně přesně definován. Nejasná však zůstává jeho patogeneze. V přehledu jsou uvedeny nové definice metabolického syndromu, přehled diskutovaných teorií a přehled patofyziologických okruhů narušených u tohoto velmi častého a významného onemocnění.
