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Comprehensive review of cardiovascular toxicity of drugs and related agents

P. Mladěnka, L. Applová, J. Patočka, VM. Costa, F. Remiao, J. Pourová, A. Mladěnka, J. Karlíčková, L. Jahodář, M. Vopršalová, KJ. Varner, M. Štěrba, . ,

. 2018 ; 38 (4) : 1332-1403. [pub] 20180105

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc19012936

Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases. Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medicinal chemists. Particular emphasis is given to clinically relevant topics including the cardiovascular toxicity of illicit sympathomimetic drugs (e.g., cocaine, amphetamines, cathinones), drugs that prolong the QT interval, antidysrhythmic drugs, digoxin and other cardioactive steroids, beta-blockers, calcium channel blockers, female hormones, nonsteroidal anti-inflammatory, and anticancer compounds encompassing anthracyclines and novel targeted therapy interfering with the HER2 or the vascular endothelial growth factor pathway.

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$a Patočka, Jiří $u Department of Radiology and Toxicology, Faculty of Health and Social Studies, University of South Bohemia, České Budějovice, Czech Republic. Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.
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$a Pourová, Jana $u Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic.
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$a Mladěnka, Aleš $u Oncogynaecologic Center, Department of Gynecology and Obstetrics, University Hospital, Ostrava, Czech Republic.
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