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Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
P. Bastard, A. Gervais, T. Le Voyer, J. Rosain, Q. Philippot, J. Manry, E. Michailidis, HH. Hoffmann, S. Eto, M. Garcia-Prat, L. Bizien, A. Parra-Martínez, R. Yang, L. Haljasmägi, M. Migaud, K. Särekannu, J. Maslovskaja, N. de Prost, Y....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, práce podpořená grantem
Grantová podpora
ZIA AI001270
Intramural NIH HHS - United States
UM1 HG006504
NHGRI NIH HHS - United States
P01 AI138398-S1
NIH HHS - United States
1ZIA AI001265
Intramural NIH HHS - United States
Howard Hughes Medical Institute - United States
UL1 TR001866
NCATS NIH HHS - United States
2U19 AI111825
NIH HHS - United States
U24 HG008956
NHGRI NIH HHS - United States
R01 AI088364
NIAID NIH HHS - United States
R01 AI091707-10S1
NIH HHS - United States
- MeSH
- autoprotilátky krev imunologie MeSH
- COVID-19 imunologie mortalita MeSH
- dítě MeSH
- dospělí MeSH
- imunoglobulin G krev imunologie MeSH
- interferon alfa imunologie MeSH
- interferon typ I imunologie MeSH
- kojenec MeSH
- kritický stav MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- neutralizující protilátky krev imunologie MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.
Aix Marseille Université IRD APHM MEPHI Marseille France
AP HP Bichat Claude Bernard Hospital Infectious and Tropical Diseases Department Paris France
AP HP Département Epidémiologie Biostatistiques et Recherche Clinique Hôpital Bichat Paris France
Cancer Genetics and Prevention Program University of California San Francisco San Francisco USA
Catalan Institution for Research and Advanced Studies Barcelona Spain
Cerba Health Care Issy les Moulineaux France
Chair of Human Genomics and Evolution Collège de France Paris France
CHU Lille Pôle de Réanimation Hôpital Roger Salengro Lille France
CIBER de Enfermedades Respiratorias Instituto de Salud Carlos 3 Madrid Spain
CNRS UMR 5308 ENS UCBL Lyon France
College of Medicine Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia
CREA Laboratory Diagnostic Department ASST Spedali Civili di Brescia Brescia Italy
Department of Biomedicine Aarhus University Aarhus Denmark
Department of Biosciences and Nutrition Karolinska Institutet Stockholm Sweden
Department of Clinical Immunology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Department of Clinical Laboratory Hospital Universitari de Bellvitge IDIBELL Barcelona Spain
Department of Critical Care Medicine Clinica Universidad de La Sabana Chia Colombia
Department of Genetics Yale University School of Medicine New Haven CT USA
Department of Hematology Necker Hospital AP HP Paris France
Department of Immunology Hospital Universitari de Bellvitge IDIBELL Barcelona Spain
Department of Immunology Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil
Department of Infectious Diseases Aarhus University Hospital Skejby Denmark
Department of Infectious Diseases San Gerardo Hospital University of Milano Bicocca Monza Italy
Department of Internal Medicine 2 Medical University of Innsbruck Innsbruck Austria
Department of Internal Medicine Hospital Universitari de Bellvitge IDIBELL Barcelona Spain
Department of Internal Medicine Infanta Leonor University Hospital Madrid Spain
Department of Medical Genetics Acibadem University School of Medicine Istanbul Turkey
Department of Medical Gerontology School of Medicine Trinity College Dublin
Department of Medical Microbiology University Medical Center Utrecht Utrecht Netherlands
Department of Microbiology Universidad de La Sabana Chia Colombia
Department of Molecular Biology and Genetics Bilkent University Bilkent Ankara Turkey
Department of Nephrology and Transplantation Necker University Hospital APHP Paris France
Department of Neurology Amsterdam Neuroscience Amsterdam Netherlands
Department of Neurosurgery Yale University School of Medicine New Haven CT USA
Department of Paediatrics and Adolescent Medicine The University of Hong Kong Hong Kong China
Department of Pediatrics Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy
Department of Pediatrics King Fahad Hospital of the University Al Khobar Saudi Arabia
Diabetes Center University of California San Francisco CA USA
Diabetes Research Institute IRCCS San Raffaele Scientific Institute Milan Italy
Division of Geriatric Medicine Tours University Medical Center Tours France
Etablissement Français du Sang Auvergne Rhône Alpes St Etienne St Etienne France
Etablissement Français du Sang La Plaine St Denis France
Faculdades Pequeno Príncipe Instituto de Pesquisa Pelé Pequeno Príncipe Curitiba Brazil
Faculty of Medical Sciences University Goce Delchev Stip Republic of Northern Macedonia
Feinstein Institutes for Medical Research Northwell Health Manhasset NY USA
Fundación Rioja Salud Centro de Investigación Biomédica de La Rioja Logrono Spain
Garvan Institute of Medical Research Sydney Australia
Hematology and Bone Marrow Transplantation Unit IRCCS San Raffaele Scientific Institute Milano Italy
Hospices Civils de Lyon Lyon France
Hospital Universitari Mutua Tarrassa Tarrasa Spain
Hospital Universitario de Gran Canaria Dr Negrín Canarian Health System Canary Islands Spain
Howard Hughes Medical Institute New York NY USA
Human Evolutionary Genetics Unit Institut Pasteur CNRS UMR 2000 Paris France
Imagine Institute Université de Paris INSERM UMR 1163 Paris France
Immunopathology Federation LIFE Hospices Civils de Lyon Lyon France
INEM INSERM U 1151 CNRS UMR 8253 Paris University Paris France
Infectious Diseases and Immunity Center for Health and Social Care Research Vic Spain
INSERM U1138 Centre de Recherche des Cordeliers Paris France
INSERM U1259 MAVIVH Université de Tours Tours France
INSERM UMRS_1166 iCAN Institute of Cardiometabolism and Nutrition Paris France
Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain
Institut Hospitalo Universitaire Méditerranée Infection Marseille France
Institut Pasteur de Lille Lille France
Institute for Biomedical Research Spanish Research Council Barcelona Spain
Institute for Systems Biology Seattle WA 98109 USA
Institute of Biomedicine and Translational Medicine University of Tartu Tartu Estonia
Institute of public health of Republic of North Macedonia
Intensive Care Department Donostia University Hospital San Sebastian Spain
Intensive Care Unit Grand Hôpital de l'Est Francilien Site de Marne la Vallée Jossigny France
Internal Medicine Department Lariboisière Hospital AP HP Paris University Paris France
Laboratoire d'Immunologie Hospices Civils de Lyon Hôpital Edouard Herriot Lyon France
Laboratory of Human Genetics and Genomics The Rockefeller University New York NY
Laboratory of Molecular Immunology Rockefeller University New York NY USA
Laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA
Medical Intensive care Unit University Hospitals Leuven Leuven Belgium
Meram Medical Faculty Necmettin Erbakan University Meram Medical Faculty Konya Turkey
National Referee Centre for Rheumatic and Autoimmune and Systemic Diseases in Children Lyon France
NIAID Clinical Genomics Program National Institutes of Health Bethesda USA
Paris Cardiovascular Center PARCC Inserm Université de Paris Paris France
Pathogenesis and Therapy of Primary Immunodeficiencies Unit San Raffaele Milano Italy
Precision Medicine Unit Lausanne University Hospital and University of Lausanne Lausanne Switzerland
Primary Immunodeficiencies Group University of Antioquia UdeA Medellin Colombia
Réanimation Médicale et Toxicologique Hôpital Lariboisière 1144
Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel
SAINBIOSE INSERM U1059 University of Lyon Université Jean Monnet Saint Etienne
School of Life Sciences Ecole Polytechnique Fédérale de Lausanne Lausanne Switzerland
School of Microbiology University of Antioquia UdeA Medellin Colombia
Service de Bactériologie Virologie Hygiène CHU de Tours Tours France
Service de Biologie Clinique and UMR S 1176 Hopital Foch Suresnes France
Service de Biologie Médicale CHI Robert Ballanger Aulnay sous Bois France
Service de Médecine Interne Hôpital universitaire Jean Verdier AP HP Bondy France
Service de Parasitologie Mycologie Groupe Hospitalier Pitié Salpêtrière AP HP Paris France
Shupyk National Healthcare University of Ukraine Kyiv Ukraine
Sorbonne Université Inserm Centre d'Immunologie et des Maladies Infectieuses Paris France
Swiss Institue of Bioinformatics Lausanne Switzerland
The Genetics Institute Tel Aviv Sourasky Medical Center Tel Aviv University Tel Aviv Israel
Translational Immunology Lab Institut Pasteur
UMR 1098 RIGHT Inserm EFS Université de Franche Comté Besançon France
Université de Lille Inserm CHU Lille Institut Pasteur de Lille U1011 EGID F 59000 Lille France
Université de Paris IAME UMR S 1137 INSERM Paris France
Université de Paris Université Paris Saclay UVSQ Inserm UMS11 Villejuif France
University of Bordeaux INSERM Bordeaux Population Health Center UMR1219 F 33000 Bordeaux France
University of Lille U1019 UMR9017 Center for Infection and Immunity of Lille Lille France
University of Paris Imagine Institute Paris France
University of Sao Paulo Sao Paulo Brazil
Yale Center for Genome Analysis Yale School of Medicine New Haven CT USA
Citace poskytuje Crossref.org
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- $a Bastard, Paul $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. jean-laurent.casanova@rockefeller.edu paul.bastard@institutimagine.org $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
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- $a Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths / $c P. Bastard, A. Gervais, T. Le Voyer, J. Rosain, Q. Philippot, J. Manry, E. Michailidis, HH. Hoffmann, S. Eto, M. Garcia-Prat, L. Bizien, A. Parra-Martínez, R. Yang, L. Haljasmägi, M. Migaud, K. Särekannu, J. Maslovskaja, N. de Prost, Y. Tandjaoui-Lambiotte, CE. Luyt, B. Amador-Borrero, A. Gaudet, J. Poissy, P. Morel, P. Richard, F. Cognasse, J. Troya, S. Trouillet-Assant, A. Belot, K. Saker, P. Garçon, JG. Rivière, JC. Lagier, S. Gentile, LB. Rosen, E. Shaw, T. Morio, J. Tanaka, D. Dalmau, PL. Tharaux, D. Sene, A. Stepanian, B. Megarbane, V. Triantafyllia, A. Fekkar, JR. Heath, JL. Franco, JM. Anaya, J. Solé-Violán, L. Imberti, A. Biondi, P. Bonfanti, R. Castagnoli, OM. Delmonte, Y. Zhang, AL. Snow, SM. Holland, C. Biggs, M. Moncada-Vélez, AA. Arias, L. Lorenzo, S. Boucherit, B. Coulibaly, D. Anglicheau, AM. Planas, F. Haerynck, S. Duvlis, RL. Nussbaum, T. Ozcelik, S. Keles, AA. Bousfiha, J. El Bakkouri, C. Ramirez-Santana, S. Paul, Q. Pan-Hammarström, L. Hammarström, A. Dupont, A. Kurolap, CN. Metz, A. Aiuti, G. Casari, V. Lampasona, F. Ciceri, LA. Barreiros, E. Dominguez-Garrido, M. Vidigal, M. Zatz, D. van de Beek, S. Sahanic, I. Tancevski, Y. Stepanovskyy, O. Boyarchuk, Y. Nukui, M. Tsumura, L. Vidaur, SG. Tangye, S. Burrel, D. Duffy, L. Quintana-Murci, A. Klocperk, NY. Kann, A. Shcherbina, YL. Lau, D. Leung, M. Coulongeat, J. Marlet, R. Koning, LF. Reyes, A. Chauvineau-Grenier, F. Venet, G. Monneret, MC. Nussenzweig, R. Arrestier, I. Boudhabhay, H. Baris-Feldman, D. Hagin, J. Wauters, I. Meyts, AH. Dyer, SP. Kennelly, NM. Bourke, R. Halwani, NS. Sharif-Askari, K. Dorgham, J. Sallette, SM. Sedkaoui, S. AlKhater, R. Rigo-Bonnin, F. Morandeira, L. Roussel, DC. Vinh, SR. Ostrowski, A. Condino-Neto, C. Prando, A. Bonradenko, AN. Spaan, L. Gilardin, J. Fellay, S. Lyonnet, K. Bilguvar, RP. Lifton, S. Mane, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James's Hospital, SARS CoV2 Interest group, French COVID Cohort Study Group, Imagine COVID-Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19, Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study, Cerba Health-Care, Etablissement du Sang study group, MS. Anderson, B. Boisson, V. Béziat, SY. Zhang, E. Vandreakos, O. Hermine, A. Pujol, P. Peterson, TH. Mogensen, L. Rowen, J. Mond, S. Debette, X. de Lamballerie, X. Duval, F. Mentré, M. Zins, P. Soler-Palacin, R. Colobran, G. Gorochov, X. Solanich, S. Susen, J. Martinez-Picado, D. Raoult, M. Vasse, PK. Gregersen, L. Piemonti, C. Rodríguez-Gallego, LD. Notarangelo, HC. Su, K. Kisand, S. Okada, A. Puel, E. Jouanguy, CM. Rice, P. Tiberghien, Q. Zhang, A. Cobat, L. Abel, JL. Casanova
- 520 9_
- $a Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.
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- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
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- 650 _2
- $a neutralizující protilátky $x krev $x imunologie $7 D057134
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- 650 _2
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- $a Shaw, Elana $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA
- 700 1_
- $a Morio, Tomohiro $u Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
- 700 1_
- $a Tanaka, Junko $u Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
- 700 1_
- $a Dalmau, David $u Hospital Universitari Mutua Tarrassa, Tarrasa, Spain
- 700 1_
- $a Tharaux, Pierre-Louis $u Paris Cardiovascular Center, PARCC, Inserm, Université de Paris, Paris, France
- 700 1_
- $a Sene, Damien $u Internal Medicine Department, Lariboisière Hospital, AP-HP, Paris University, Paris, France
- 700 1_
- $a Stepanian, Alain $u Service d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris and EA3518, Institut Universitaire d'Hématologie-Hôpital Saint Louis, Université Paris Diderot, Paris, France
- 700 1_
- $a Megarbane, Bruno $u Réanimation Médicale et Toxicologique, Hôpital Lariboisière (AP-HP), Université Paris-Diderot, INSERM Unité Mixte de Recherche Scientifique (UMRS) 1144
- 700 1_
- $a Triantafyllia, Vasiliki $u Laboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece
- 700 1_
- $a Fekkar, Arnaud $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u Service de Parasitologie-Mycologie, Groupe Hospitalier Pitié Salpêtrière, AP-HP, Paris, France
- 700 1_
- $a Heath, James R $u Institute for Systems Biology, Seattle, WA 98109, USA
- 700 1_
- $a Franco, José Luis $u Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UDEA, Medellín, Colombia
- 700 1_
- $a Anaya, Juan-Manuel $u Center for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia
- 700 1_
- $a Solé-Violán, Jordi $u Critical Care Unit, University Hospital of Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Canary Islands, Spain $u CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
- 700 1_
- $a Imberti, Luisa $u CREA Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy
- 700 1_
- $a Biondi, Andrea $u Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy
- 700 1_
- $a Bonfanti, Paolo $u Department of Infectious Diseases, San Gerardo Hospital-University of Milano-Bicocca, Monza, Italy
- 700 1_
- $a Castagnoli, Riccardo $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA $u Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
- 700 1_
- $a Delmonte, Ottavia M $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA
- 700 1_
- $a Zhang, Yu $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA $u NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, USA
- 700 1_
- $a Snow, Andrew L $u Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
- 700 1_
- $a Holland, Steven M $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA
- 700 1_
- $a Biggs, Catherine $u Department of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, BC, Canada
- 700 1_
- $a Moncada-Vélez, Marcela $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
- 700 1_
- $a Arias, Andrés Augusto $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA $u Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia $u School of Microbiology, University of Antioquia UdeA, Medellin, Colombia
- 700 1_
- $a Lorenzo, Lazaro $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France
- 700 1_
- $a Boucherit, Soraya $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France
- 700 1_
- $a Coulibaly, Boubacar $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France
- 700 1_
- $a Anglicheau, Dany $u Department of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France
- 700 1_
- $a Planas, Anna M $u Institute for Biomedical Research, Spanish Research Council, Barcelona, Spain $u Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
- 700 1_
- $a Haerynck, Filomeen $u Department of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium
- 700 1_
- $a Duvlis, Sotirija $u Faculty of Medical Sciences, University "Goce Delchev", Stip, Republic of Northern Macedonia $u Institute of public health of Republic of North Macedonia
- 700 1_
- $a Nussbaum, Robert L $u Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, USA
- 700 1_
- $a Ozcelik, Tayfun $u Department of Molecular Biology and Genetics, Bilkent University, Bilkent - Ankara, Turkey
- 700 1_
- $a Keles, Sevgi $u Meram Medical Faculty, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey
- 700 1_
- $a Bousfiha, Ahmed A $u Clinical Immunology Unit, Department of Pediatric Infectious Disease, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
- 700 1_
- $a El Bakkouri, Jalila $u Clinical Immunology Unit, Department of Pediatric Infectious Disease, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
- 700 1_
- $a Ramirez-Santana, Carolina $u Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UDEA, Medellín, Colombia $u Center for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia
- 700 1_
- $a Paul, Stéphane $u Department of Immunology, CIC1408, GIMAP CIRI INSERM U1111, University Hospital of Saint-Etienne, Saint-Etienne, France
- 700 1_
- $a Pan-Hammarström, Qiang $u Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
- 700 1_
- $a Hammarström, Lennart $u Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
- 700 1_
- $a Dupont, Annabelle $u Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, F-59000 Lille, France
- 700 1_
- $a Kurolap, Alina $u The Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
- 700 1_
- $a Metz, Christine N $u Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA
- 700 1_
- $a Aiuti, Alessandro $u Pathogenesis and Therapy of Primary Immunodeficiencies Unit, San Raffaele, Milano, Italy
- 700 1_
- $a Casari, Giorgio $u Pathogenesis and Therapy of Primary Immunodeficiencies Unit, San Raffaele, Milano, Italy
- 700 1_
- $a Lampasona, Vito $u Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
- 700 1_
- $a Ciceri, Fabio $u Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy
- 700 1_
- $a Barreiros, Lucila A $u Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
- 700 1_
- $a Dominguez-Garrido, Elena $u Fundación Rioja Salud - Centro de Investigación Biomédica de La Rioja, Logrono, Spain
- 700 1_
- $a Vidigal, Mateus $u University of Sao Paulo, Sao Paulo, Brazil
- 700 1_
- $a Zatz, Mayana $u University of Sao Paulo, Sao Paulo, Brazil
- 700 1_
- $a van de Beek, Diederik $u Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands
- 700 1_
- $a Sahanic, Sabina $u Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria
- 700 1_
- $a Tancevski, Ivan $u Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria
- 700 1_
- $a Stepanovskyy, Yurii $u Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
- 700 1_
- $a Boyarchuk, Oksana $u Department of Children's Diseases and Pediatric Surgery, I.Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
- 700 1_
- $a Nukui, Yoko $u Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
- 700 1_
- $a Tsumura, Miyuki $u Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
- 700 1_
- $a Vidaur, Loreto $u Intensive Care Department, Donostia University Hospital, San Sebastian, Spain $u Centro de Investigación en Red de Enfermedades Respiratorias-CIBERES - Instituto de Salud Carlos III, Madrid, España
- 700 1_
- $a Tangye, Stuart G $u Garvan Institute of Medical Research, Sydney, Australia
- 700 1_
- $a Burrel, Sonia $u Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Service de Virologie, Paris, France
- 700 1_
- $a Duffy, Darragh $u Translational Immunology Lab, Institut Pasteur
- 700 1_
- $a Quintana-Murci, Lluis $u Human Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, Paris, France $u Chair of Human Genomics and Evolution, Collège de France, Paris, France
- 700 1_
- $a Klocperk, Adam $u Department of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital in Motol, Prague, Czech Republic
- 700 1_
- $a Kann, Nelli Y $u Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia
- 700 1_
- $a Shcherbina, Anna $u Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia
- 700 1_
- $a Lau, Yu-Lung $u Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong, China
- 700 1_
- $a Leung, Daniel $u Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong, China
- 700 1_
- $a Coulongeat, Matthieu $u Division of Geriatric Medicine, Tours University Medical Center, Tours, France
- 700 1_
- $a Marlet, Julien $u INSERM U1259, MAVIVH, Université de Tours, Tours, France $u Service de Bactériologie-Virologie-Hygiène, CHU de Tours, Tours, France
- 700 1_
- $a Koning, Rutger $u Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands
- 700 1_
- $a Reyes, Luis Felipe $u Department of Microbiology, Universidad de La Sabana, Chia, Colombia $u Department of Critical Care Medicine, Clinica Universidad de La Sabana, Chia, Colombia
- 700 1_
- $a Chauvineau-Grenier, Angélique $u Service de Biologie Médicale, CHI Robert Ballanger, Aulnay sous Bois, France
- 700 1_
- $a Venet, Fabienne $u Laboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France $u EA 7426 « Pathophysiology of Injury-Induced Immunosuppression », Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, Hôpital Edouard Herriot - BioMérieux, Lyon, France
- 700 1_
- $a Monneret, Guillaume $u Laboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France $u EA 7426 « Pathophysiology of Injury-Induced Immunosuppression », Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, Hôpital Edouard Herriot - BioMérieux, Lyon, France
- 700 1_
- $a Nussenzweig, Michel C $u Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA $u Howard Hughes Medical Institute, New York, NY, USA
- 700 1_
- $a Arrestier, Romain $u Service de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique - Hôpitaux de Paris (AP-HP) $u Groupe de Recherche Clinique CARMAS, Faculté de Santé de Créteil, Université Paris Est Créteil, 51, Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil Cedex, France
- 700 1_
- $a Boudhabhay, Idris $u Department of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France
- 700 1_
- $a Baris-Feldman, Hagit $u The Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
- 700 1_
- $a Hagin, David $u Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel $u Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
- 700 1_
- $a Wauters, Joost $u Medical Intensive care Unit, University Hospitals Leuven, Leuven, Belgium
- 700 1_
- $a Meyts, Isabelle $u Laboratory of Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, KU Leuven, Leuven, Belgium $u Department of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center, University Hospitals Leuven, Leuven, Belgium
- 700 1_
- $a Dyer, Adam H $u Department of Age-Related Healthcare, Tallaght University Hospital & Department of Medical Gerontology, School of Medicine, Trinity College Dublin
- 700 1_
- $a Kennelly, Sean P $u Department of Age-Related Healthcare, Tallaght University Hospital & Department of Medical Gerontology, School of Medicine, Trinity College Dublin
- 700 1_
- $a Bourke, Nollaig M $u Department of Medical Gerontology, School of Medicine, Trinity College Dublin
- 700 1_
- $a Halwani, Rabih $u Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
- 700 1_
- $a Sharif-Askari, Narjes Saheb $u Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
- 700 1_
- $a Dorgham, Karim $u Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, (CIMI- Paris), Paris, France
- 700 1_
- $a Sallette, Jérome $u Cerba Health Care, Issy-les-Moulineaux, France
- 700 1_
- $a Sedkaoui, Souad Mehlal $u Cerba Health Care, Issy-les-Moulineaux, France
- 700 1_
- $a AlKhater, Suzan $u Department of Pediatrics, King Fahad Hospital of the University, Al-Khobar, Saudi Arabia $u College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
- 700 1_
- $a Rigo-Bonnin, Raúl $u Department of Clinical Laboratory, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
- 700 1_
- $a Morandeira, Francisco $u Department of Immunology, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
- 700 1_
- $a Roussel, Lucie $u Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada $u Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada
- 700 1_
- $a Vinh, Donald C $u Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada $u Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada
- 700 1_
- $a Ostrowski, Sisse Rye $u Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
- 700 1_
- $a Condino-Neto, Antonio $u Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
- 700 1_
- $a Prando, Carolina $u Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil
- 700 1_
- $a Bonradenko, Anastasiia $u Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
- 700 1_
- $a Spaan, András N $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA $u Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands
- 700 1_
- $a Gilardin, Laurent $u Service de Médecine Interne, Hôpital universitaire Jean-Verdier, AP-HP, Bondy, France $u INSERM U1138, Centre de Recherche des Cordeliers, Paris, France
- 700 1_
- $a Fellay, Jacques $u School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland $u Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland $u Swiss Institue of Bioinformatics, Lausanne, Switzerland
- 700 1_
- $a Lyonnet, Stanislas $u Imagine Institute, Université de Paris, INSERM UMR 1163, Paris, France
- 700 1_
- $a Bilguvar, Kaya $u Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA $u Department of Genetics, Yale University School of Medicine, New Haven, CT, USA $u Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA $u Department of Medical Genetics, Acibadem University School of Medicine, Istanbul, Turkey
- 700 1_
- $a Lifton, Richard P $u Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA $u Department of Genetics, Yale University School of Medicine, New Haven, CT, USA $u Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY
- 700 1_
- $a Mane, Shrikant $u Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
- 700 1_
- $a Anderson, Mark S $u Diabetes Center, University of California, San Francisco, CA, USA
- 700 1_
- $a Boisson, Bertrand $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
- 700 1_
- $a Béziat, Vivien $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France
- 700 1_
- $a Zhang, Shen-Ying $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
- 700 1_
- $a Vandreakos, Evangelos $u Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
- 700 1_
- $a Hermine, Olivier $u University of Paris, Imagine Institute, Paris, France $u Department of Hematology, Necker Hospital, AP-HP, Paris, France
- 700 1_
- $a Pujol, Aurora $u Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain
- 700 1_
- $a Peterson, Pärt $u Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
- 700 1_
- $a Mogensen, Trine H $u Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark $u Department of Biomedicine, Aarhus University, Aarhus, Denmark
- 700 1_
- $a Rowen, Lee $u Institute for Systems Biology, Seattle, WA 98109, USA
- 700 1_
- $a Mond, James $u ADMA Biologics Inc., Ramsey NJ
- 700 1_
- $a Debette, Stéphanie $u University of Bordeaux, INSERM, Bordeaux Population Health Center, UMR1219, F-33000 Bordeaux, France $u Bordeaux University Hospital, Department of Neurology, Institute of Neurodegenerative Diseases, F-33000 Bordeaux, France
- 700 1_
- $a de Lamballerie, Xavier $u IHU Méditerranée Infection, Unité des Virus Émergents, UVE: Aix Marseille University, IRD 190, INSERM 1207, Marseille, France
- 700 1_
- $a Duval, Xavier $u Inserm CIC 1425, Paris, France $u Université de Paris, IAME UMR-S 1137, INSERM, Paris, France $u AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France $u AP-HP, Bichat Claude Bernard Hospital, Infectious and Tropical Diseases Department, Paris, France
- 700 1_
- $a Mentré, France $u Inserm CIC 1425, Paris, France $u Université de Paris, IAME UMR-S 1137, INSERM, Paris, France $u AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France
- 700 1_
- $a Zins, Marie $u Université de Paris, Université Paris-Saclay, UVSQ, Inserm UMS11, Villejuif, France
- 700 1_
- $a Soler-Palacin, Pere $u Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain
- 700 1_
- $a Colobran, Roger $u Immunology Division, Genetics Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, UAB, Barcelona, Catalonia, Spain
- 700 1_
- $a Gorochov, Guy $u Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, (CIMI- Paris), Paris, France $u Département d'Immunologie, Assistance Publique Hôpitaux de Paris (AP-HP), Hôpital Pitié-Salpétrière, Paris, France
- 700 1_
- $a Solanich, Xavier $u Department of Internal Medicine, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
- 700 1_
- $a Susen, Sophie $u Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, F-59000 Lille, France
- 700 1_
- $a Martinez-Picado, Javier $u IrsiCaixa AIDS Research Institute and Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain $u Infectious Diseases and Immunity, Center for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain $u Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain
- 700 1_
- $a Raoult, Didier $u Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France $u Aix Marseille Université, IRD, APHM, MEPHI, Marseille, France
- 700 1_
- $a Vasse, Marc $u Service de Biologie Clinique & UMR-S 1176, Hopital Foch, Suresnes, France
- 700 1_
- $a Gregersen, Peter K $u Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA
- 700 1_
- $a Piemonti, Lorenzo $u Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
- 700 1_
- $a Rodríguez-Gallego, Carlos $u Hospital Universitario de Gran Canaria Dr Negrín, Canarian Health System, Canary Islands, Spain $u Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Canary Islands, Spain
- 700 1_
- $a Notarangelo, Luigi D $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA
- 700 1_
- $a Su, Helen C $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA $u Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
- 700 1_
- $a Kisand, Kai $u Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
- 700 1_
- $a Okada, Satoshi $u Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
- 700 1_
- $a Puel, Anne $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
- 700 1_
- $a Jouanguy, Emmanuelle $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
- 700 1_
- $a Rice, Charles M $u Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
- 700 1_
- $a Tiberghien, Pierre $u Etablissement Français du Sang, La Plaine-St Denis, France $u UMR 1098 RIGHT, Inserm, EFS, Université de Franche-Comté, Besançon, France
- 700 1_
- $a Zhang, Qian $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
- 700 1_
- $a Cobat, Aurélie $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
- 700 1_
- $a Abel, Laurent $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
- 700 1_
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