Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.

ADMA Biologics Inc Ramsey NJ

Aix Marseille Université IRD APHM MEPHI Marseille France

Aix Marseille University School of Medicine La Timone Medical Campus EA 3279 CEReSS Health Service Research and Quality of Life Center Marseille France

Allergy and Clinical Immunology Unit Department of Medicine Tel Aviv Sourasky Medical Center Tel Aviv Israel

AP HP Bichat Claude Bernard Hospital Infectious and Tropical Diseases Department Paris France

AP HP Département Epidémiologie Biostatistiques et Recherche Clinique Hôpital Bichat Paris France

Avicenne Hospital Assistance Publique Hôpitaux de Paris Bobigny INSERM U1272 Hypoxia and Lung Bobigny France

Bordeaux University Hospital Department of Neurology Institute of Neurodegenerative Diseases F 33000 Bordeaux France

Cancer Genetics and Prevention Program University of California San Francisco San Francisco USA

Catalan Institution for Research and Advanced Studies Barcelona Spain

Center for Autoimmune Disease Research School of Medicine and Health Sciences Universidad del Rosario Bogota Colombia

Center for Clinical Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens Athens Greece

Centro de Investigación en Red de Enfermedades Respiratorias CIBERES Instituto de Salud Carlos 3 Madrid España

Cerba Health Care Issy les Moulineaux France

Chair of Human Genomics and Evolution Collège de France Paris France

CHU Lille Pôle de Réanimation Hôpital Roger Salengro Lille France

CIBER de Enfermedades Respiratorias Instituto de Salud Carlos 3 Madrid Spain

Clinical Immunology Unit Department of Pediatric Infectious Disease CHU Ibn Rushd and LICIA Laboratoire d'Immunologie Clinique Inflammation et Allergie Faculty of Medicine and Pharmacy Hassan 2 University Casablanca Morocco

CNRS UMR 5308 ENS UCBL Lyon France

CNRS UMR9017 Lille France

College of Medicine Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia

CREA Laboratory Diagnostic Department ASST Spedali Civili di Brescia Brescia Italy

Critical Care Unit University Hospital of Gran Canaria Dr Negrín Canarian Health System Las Palmas de Gran Canaria Canary Islands Spain

Département d'Immunologie Assistance Publique Hôpitaux de Paris Hôpital Pitié Salpétrière Paris France

Department of Age Related Healthcare Tallaght University Hospital and Department of Medical Gerontology School of Medicine Trinity College Dublin

Department of Biomedicine Aarhus University Aarhus Denmark

Department of Biosciences and Nutrition Karolinska Institutet Stockholm Sweden

Department of Children's Diseases and Pediatric Surgery 1 Horbachevsky Ternopil National Medical University Ternopil Ukraine

Department of Clinical Immunology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark

Department of Clinical Laboratory Hospital Universitari de Bellvitge IDIBELL Barcelona Spain

Department of Clinical Sciences University Fernando Pessoa Canarias Las Palmas de Gran Canaria Canary Islands Spain

Department of Critical Care Medicine Clinica Universidad de La Sabana Chia Colombia

Department of Epidemiology Infectious Disease Control and Prevention Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan

Department of Genetics Yale University School of Medicine New Haven CT USA

Department of Hematology Necker Hospital AP HP Paris France

Department of Immunology 2nd Faculty of Medicine Charles University and University Hospital in Motol Prague Czech Republic

Department of Immunology CIC1408 GIMAP CIRI INSERM U1111 University Hospital of Saint Etienne Saint Etienne France

Department of Immunology Hospital Universitari de Bellvitge IDIBELL Barcelona Spain

Department of Immunology Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil

Department of Infection Control and Prevention Medical Hospital Tokyo Medical and Dental University Tokyo Japan

Department of Infectious Diseases Aarhus University Hospital Skejby Denmark

Department of Infectious Diseases San Gerardo Hospital University of Milano Bicocca Monza Italy

Department of Internal Medicine 2 Medical University of Innsbruck Innsbruck Austria

Department of Internal Medicine Hospital Universitari de Bellvitge IDIBELL Barcelona Spain

Department of Internal Medicine Infanta Leonor University Hospital Madrid Spain

Department of Medical Genetics Acibadem University School of Medicine Istanbul Turkey

Department of Medical Gerontology School of Medicine Trinity College Dublin

Department of Medical Microbiology University Medical Center Utrecht Utrecht Netherlands

Department of Medicine Division of Infectious Diseases McGill University Health Centre Montréal Québec Canada

Department of Microbiology Universidad de La Sabana Chia Colombia

Department of Molecular Biology and Genetics Bilkent University Bilkent Ankara Turkey

Department of Nephrology and Transplantation Necker University Hospital APHP Paris France

Department of Neurology Amsterdam Neuroscience Amsterdam Netherlands

Department of Neurosurgery Yale University School of Medicine New Haven CT USA

Department of Paediatric Immunology and Pulmonology Center for Primary Immunodeficiency Ghent Jeffrey Modell Diagnosis and Research Center Ghent University Hospital Ghent Belgium

Department of Paediatrics and Adolescent Medicine The University of Hong Kong Hong Kong China

Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA

Department of Pediatrics and Developmental Biology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan

Department of Pediatrics British Columbia Children's Hospital The University of British Columbia Vancouver BC Canada

Department of Pediatrics Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy

Department of Pediatrics Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan

Department of Pediatrics Jeffrey Modell Diagnostic and Research Network Center University Hospitals Leuven Leuven Belgium

Department of Pediatrics King Fahad Hospital of the University Al Khobar Saudi Arabia

Department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda MD USA

Diabetes Center University of California San Francisco CA USA

Diabetes Research Institute IRCCS San Raffaele Scientific Institute Milan Italy

Division of Geriatric Medicine Tours University Medical Center Tours France

Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia

EA 7426 « Pathophysiology of Injury Induced Immunosuppression » Université Claude Bernard Lyon 1 Hospices Civils de Lyon Hôpital Edouard Herriot BioMérieux Lyon France

Etablissement Français du Sang Auvergne Rhône Alpes St Etienne St Etienne France

Etablissement Français du Sang La Plaine St Denis France

Faculdades Pequeno Príncipe Instituto de Pesquisa Pelé Pequeno Príncipe Curitiba Brazil

Faculty of Medical Sciences University Goce Delchev Stip Republic of Northern Macedonia

Feinstein Institutes for Medical Research Northwell Health Manhasset NY USA

Fundación Rioja Salud Centro de Investigación Biomédica de La Rioja Logrono Spain

Garvan Institute of Medical Research Sydney Australia

Groupe de Recherche Clinique CARMAS Faculté de Santé de Créteil Université Paris Est Créteil 51 Avenue du Maréchal de Lattre de Tassigny 94010 Créteil Cedex France

Hematology and Bone Marrow Transplantation Unit IRCCS San Raffaele Scientific Institute Milano Italy

Hospices Civils de Lyon Lyon France

Hospital Universitari Mutua Tarrassa Tarrasa Spain

Hospital Universitario de Gran Canaria Dr Negrín Canarian Health System Canary Islands Spain

Howard Hughes Medical Institute New York NY USA

Human Evolutionary Genetics Unit Institut Pasteur CNRS UMR 2000 Paris France

IHU Méditerranée Infection Unité des Virus Émergents UVE Aix Marseille University IRD 190 INSERM 1207 Marseille France

Imagine Institute Université de Paris INSERM UMR 1163 Paris France

Immunology Division Genetics Department Hospital Universitari Vall d'Hebron Vall d'Hebron Research Institute Vall d'Hebron Barcelona Hospital Campus UAB Barcelona Catalonia Spain

Immunopathology Federation LIFE Hospices Civils de Lyon Lyon France

INEM INSERM U 1151 CNRS UMR 8253 Paris University Paris France

Infectious Disease Susceptibility Program Research Institute McGill University Health Centre Montréal Québec Canada

Infectious Diseases and Immunity Center for Health and Social Care Research Vic Spain

Inserm CIC 1425 Paris France

INSERM U1019 Lille France

INSERM U1138 Centre de Recherche des Cordeliers Paris France

INSERM U1259 MAVIVH Université de Tours Tours France

INSERM UMRS_1166 iCAN Institute of Cardiometabolism and Nutrition Paris France

Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain

Institut Hospitalo Universitaire Méditerranée Infection Marseille France

Institut Pasteur de Lille Lille France

Institute for Biomedical Research Spanish Research Council Barcelona Spain

Institute for Systems Biology Seattle WA 98109 USA

Institute of Biomedicine and Translational Medicine University of Tartu Tartu Estonia

Institute of public health of Republic of North Macedonia

Intensive Care Department Donostia University Hospital San Sebastian Spain

Intensive Care Unit Grand Hôpital de l'Est Francilien Site de Marne la Vallée Jossigny France

Internal Medicine Department Lariboisière Hospital AP HP Paris University Paris France

International Center of Research in Infectiology Lyon University INSERM U1111 CNRS UMR 5308 ENS UCBL Lyon France

IrsiCaixa AIDS Research Institute and Institute for Health Science Research Germans Trias i Pujol Badalona Spain

Joint Research Unit Hospices Civils de Lyon bio Mérieux Hospices Civils de Lyon Lyon Sud Hospital Pierre Bénite France

Laboratoire d'Immunologie Hospices Civils de Lyon Hôpital Edouard Herriot Lyon France

Laboratory of Clinical Immunology and Microbiology Division of Intramural Research NIAID NIH Bethesda MD USA

Laboratory of Human Genetics and Genomics The Rockefeller University New York NY

Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France

Laboratory of Immunobiology Center for Clinical Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens 11527 Athens Greece

Laboratory of Inborn Errors of Immunity Department of Immunology Microbiology and Transplantation KU Leuven Leuven Belgium

Laboratory of Molecular Immunology Rockefeller University New York NY USA

Laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA

Lyon

Medical Intensive care Unit University Hospitals Leuven Leuven Belgium

Meram Medical Faculty Necmettin Erbakan University Meram Medical Faculty Konya Turkey

National Referee Centre for Rheumatic and Autoimmune and Systemic Diseases in Children Lyon France

Neurometabolic Diseases Laboratory IDIBELL Hospital Duran i Reynals CIBERER U759 and Catalan Institution of Research and Advanced Studies Barcelona Spain

NIAID Clinical Genomics Program National Institutes of Health Bethesda USA

Paris Cardiovascular Center PARCC Inserm Université de Paris Paris France

Pathogenesis and Therapy of Primary Immunodeficiencies Unit San Raffaele Milano Italy

Pediatric Department and Centro Tettamanti European Reference Network PaedCan EuroBloodNet MetabERN University of Milano Bicocca Fondazione MBBM Ospedale San Gerardo Monza Italy

Pediatric Infectious Diseases and Immunodeficiencies Unit Hospital Universitari Vall d'Hebron Vall d'Hebron Research Institute Vall d'Hebron Barcelona Hospital Campus Universitat Autònoma de Barcelona Barcelona Catalonia Spain

Precision Medicine Unit Lausanne University Hospital and University of Lausanne Lausanne Switzerland

Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia UDEA Medellín Colombia

Primary Immunodeficiencies Group University of Antioquia UdeA Medellin Colombia

Réanimation Médicale et Toxicologique Hôpital Lariboisière 1144

Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel

SAINBIOSE INSERM U1059 University of Lyon Université Jean Monnet Saint Etienne

School of Life Sciences Ecole Polytechnique Fédérale de Lausanne Lausanne Switzerland

School of Microbiology University of Antioquia UdeA Medellin Colombia

Service d'Evaluation Médicale Hôpitaux Universitaires de Marseille Assistance Publique Hôpitaux de Marseille Marseille France

Service d'Hématologie Biologique Hôpital Lariboisière Assistance Publique Hôpitaux de Paris and EA3518 Institut Universitaire d'Hématologie Hôpital Saint Louis Université Paris Diderot Paris France

Service de Bactériologie Virologie Hygiène CHU de Tours Tours France

Service de Biologie Clinique and UMR S 1176 Hopital Foch Suresnes France

Service de Biologie Médicale CHI Robert Ballanger Aulnay sous Bois France

Service de Médecine Intensive Réanimation Hôpitaux Universitaires Henri Mondor Assistance Publique Hôpitaux de Paris

Service de Médecine Interne Hôpital universitaire Jean Verdier AP HP Bondy France

Service de Parasitologie Mycologie Groupe Hospitalier Pitié Salpêtrière AP HP Paris France

Sharjah Institute for Medical Research College of Medicine University of Sharjah Sharjah United Arab Emirates

Shupyk National Healthcare University of Ukraine Kyiv Ukraine

Sorbonne Université Assistance Publique Hôpitaux de Paris Hôpital Pitié Salpêtrière Médecine Intensive Réanimation AP HP Paris France

Sorbonne Université Inserm Centre d'Immunologie et des Maladies Infectieuses Paris France

Sorbonne Université INSERM U1136 Institut Pierre Louis d'Epidémiologie et de Santé Publique AP HP Hôpital Pitié Salpêtrière Service de Virologie Paris France

St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA

Swiss Institue of Bioinformatics Lausanne Switzerland

The Genetics Institute Tel Aviv Sourasky Medical Center Tel Aviv University Tel Aviv Israel

Translational Immunology Lab Institut Pasteur

UMR 1098 RIGHT Inserm EFS Université de Franche Comté Besançon France

Université de Lille Inserm CHU Lille Institut Pasteur de Lille U1011 EGID F 59000 Lille France

Université de Paris IAME UMR S 1137 INSERM Paris France

Université de Paris Université Paris Saclay UVSQ Inserm UMS11 Villejuif France

University of Bordeaux INSERM Bordeaux Population Health Center UMR1219 F 33000 Bordeaux France

University of Lille U1019 UMR9017 Center for Infection and Immunity of Lille Lille France

University of Paris Imagine Institute Paris France

University of Sao Paulo Sao Paulo Brazil

Yale Center for Genome Analysis Yale School of Medicine New Haven CT USA

000      

00000naa a2200000 a 4500

001      

bmc21025105

003      

CZ-PrNML

005      

20211026134124.0

007      

ta

008      

211013s2021 xxu f 000 0|eng||

009      

AR

024    7_

$a 10.1126/sciimmunol.abl4340 $2 doi

035    __

$a (PubMed)34413139

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a xxu

100    1_

$a Bastard, Paul $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. jean-laurent.casanova@rockefeller.edu paul.bastard@institutimagine.org $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA

245    10

$a Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths / $c P. Bastard, A. Gervais, T. Le Voyer, J. Rosain, Q. Philippot, J. Manry, E. Michailidis, HH. Hoffmann, S. Eto, M. Garcia-Prat, L. Bizien, A. Parra-Martínez, R. Yang, L. Haljasmägi, M. Migaud, K. Särekannu, J. Maslovskaja, N. de Prost, Y. Tandjaoui-Lambiotte, CE. Luyt, B. Amador-Borrero, A. Gaudet, J. Poissy, P. Morel, P. Richard, F. Cognasse, J. Troya, S. Trouillet-Assant, A. Belot, K. Saker, P. Garçon, JG. Rivière, JC. Lagier, S. Gentile, LB. Rosen, E. Shaw, T. Morio, J. Tanaka, D. Dalmau, PL. Tharaux, D. Sene, A. Stepanian, B. Megarbane, V. Triantafyllia, A. Fekkar, JR. Heath, JL. Franco, JM. Anaya, J. Solé-Violán, L. Imberti, A. Biondi, P. Bonfanti, R. Castagnoli, OM. Delmonte, Y. Zhang, AL. Snow, SM. Holland, C. Biggs, M. Moncada-Vélez, AA. Arias, L. Lorenzo, S. Boucherit, B. Coulibaly, D. Anglicheau, AM. Planas, F. Haerynck, S. Duvlis, RL. Nussbaum, T. Ozcelik, S. Keles, AA. Bousfiha, J. El Bakkouri, C. Ramirez-Santana, S. Paul, Q. Pan-Hammarström, L. Hammarström, A. Dupont, A. Kurolap, CN. Metz, A. Aiuti, G. Casari, V. Lampasona, F. Ciceri, LA. Barreiros, E. Dominguez-Garrido, M. Vidigal, M. Zatz, D. van de Beek, S. Sahanic, I. Tancevski, Y. Stepanovskyy, O. Boyarchuk, Y. Nukui, M. Tsumura, L. Vidaur, SG. Tangye, S. Burrel, D. Duffy, L. Quintana-Murci, A. Klocperk, NY. Kann, A. Shcherbina, YL. Lau, D. Leung, M. Coulongeat, J. Marlet, R. Koning, LF. Reyes, A. Chauvineau-Grenier, F. Venet, G. Monneret, MC. Nussenzweig, R. Arrestier, I. Boudhabhay, H. Baris-Feldman, D. Hagin, J. Wauters, I. Meyts, AH. Dyer, SP. Kennelly, NM. Bourke, R. Halwani, NS. Sharif-Askari, K. Dorgham, J. Sallette, SM. Sedkaoui, S. AlKhater, R. Rigo-Bonnin, F. Morandeira, L. Roussel, DC. Vinh, SR. Ostrowski, A. Condino-Neto, C. Prando, A. Bonradenko, AN. Spaan, L. Gilardin, J. Fellay, S. Lyonnet, K. Bilguvar, RP. Lifton, S. Mane, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James's Hospital, SARS CoV2 Interest group, French COVID Cohort Study Group, Imagine COVID-Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19, Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study, Cerba Health-Care, Etablissement du Sang study group, MS. Anderson, B. Boisson, V. Béziat, SY. Zhang, E. Vandreakos, O. Hermine, A. Pujol, P. Peterson, TH. Mogensen, L. Rowen, J. Mond, S. Debette, X. de Lamballerie, X. Duval, F. Mentré, M. Zins, P. Soler-Palacin, R. Colobran, G. Gorochov, X. Solanich, S. Susen, J. Martinez-Picado, D. Raoult, M. Vasse, PK. Gregersen, L. Piemonti, C. Rodríguez-Gallego, LD. Notarangelo, HC. Su, K. Kisand, S. Okada, A. Puel, E. Jouanguy, CM. Rice, P. Tiberghien, Q. Zhang, A. Cobat, L. Abel, JL. Casanova

520    9_

$a Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.

650    _2

$a mladiství $7 D000293

650    _2

$a dospělí $7 D000328

650    _2

$a senioři $7 D000368

650    _2

$a senioři nad 80 let $7 D000369

650    _2

$a neutralizující protilátky $x krev $x imunologie $7 D057134

650    _2

$a autoprotilátky $x krev $x imunologie $7 D001323

650    _2

$a COVID-19 $x imunologie $x mortalita $7 D000086382

650    _2

$a studie případů a kontrol $7 D016022

650    _2

$a dítě $7 D002648

650    _2

$a předškolní dítě $7 D002675

650    _2

$a kritický stav $7 D016638

650    _2

$a lidé $7 D006801

650    _2

$a imunoglobulin G $x krev $x imunologie $7 D007074

650    _2

$a kojenec $7 D007223

650    _2

$a novorozenec $7 D007231

650    _2

$a interferon typ I $x imunologie $7 D007370

650    _2

$a interferon alfa $x imunologie $7 D016898

650    _2

$a lidé středního věku $7 D008875

650    _2

$a mladý dospělý $7 D055815

655    _2

$a časopisecké články $7 D016428

655    _2

$a Research Support, N.I.H., Extramural $7 D052061

655    _2

$a Research Support, N.I.H., Intramural $7 D052060

655    _2

$a práce podpořená grantem $7 D013485

700    1_

$a Gervais, Adrian $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France

700    1_

$a Le Voyer, Tom $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France

700    1_

$a Rosain, Jérémie $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France

700    1_

$a Philippot, Quentin $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France

700    1_

$a Manry, Jérémy $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France

700    1_

$a Michailidis, Eleftherios $u Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA

700    1_

$a Hoffmann, Hans-Heinrich $u Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA

700    1_

$a Eto, Shohei $u Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

700    1_

$a Garcia-Prat, Marina $u Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain

700    1_

$a Bizien, Lucy $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France

700    1_

$a Parra-Martínez, Alba $u Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain

700    1_

$a Yang, Rui $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA

700    1_

$a Haljasmägi, Liis $u Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia

700    1_

$a Migaud, Mélanie $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France

700    1_

$a Särekannu, Karita $u Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia

700    1_

$a Maslovskaja, Julia $u Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia

700    1_

$a de Prost, Nicolas $u Service de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique - Hôpitaux de Paris (AP-HP) $u Groupe de Recherche Clinique CARMAS, Faculté de Santé de Créteil, Université Paris Est Créteil, 51, Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil Cedex, France

700    1_

$a Tandjaoui-Lambiotte, Yacine $u Avicenne Hospital, Assistance Publique Hôpitaux de Paris, Bobigny, INSERM U1272 Hypoxia & Lung, Bobigny, France

700    1_

$a Luyt, Charles-Edouard $u Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Médecine Intensive Réanimation, AP-HP, Paris, France $u INSERM UMRS_1166-iCAN, Institute of Cardiometabolism and Nutrition, Paris, France

700    1_

$a Amador-Borrero, Blanca $u Internal Medicine Department, Lariboisière Hospital, AP-HP, Paris University, Paris, France

700    1_

$a Gaudet, Alexandre $u University of Lille, U1019-UMR9017-Center for Infection and Immunity of Lille, Lille, France $u CNRS, UMR9017, Lille, France $u INSERM, U1019, Lille, France $u Institut Pasteur de Lille, Lille, France $u CHU Lille, Pôle de Réanimation, Hôpital Roger Salengro, Lille, France

700    1_

$a Poissy, Julien $u University of Lille, U1019-UMR9017-Center for Infection and Immunity of Lille, Lille, France $u CNRS, UMR9017, Lille, France $u INSERM, U1019, Lille, France $u Institut Pasteur de Lille, Lille, France $u CHU Lille, Pôle de Réanimation, Hôpital Roger Salengro, Lille, France

700    1_

$a Morel, Pascal $u Etablissement Français du Sang, La Plaine-St Denis, France $u UMR 1098 RIGHT, Inserm, EFS, Université de Franche-Comté, Besançon, France

700    1_

$a Richard, Pascale $u Etablissement Français du Sang, La Plaine-St Denis, France

700    1_

$a Cognasse, Fabrice $u SAINBIOSE, INSERM U1059, University of Lyon, Université Jean-Monnet-Saint-Etienne $u Etablissement Français du Sang, Auvergne Rhône-Alpes, St-Etienne, St-Etienne, France

700    1_

$a Troya, Jesus $u Department of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain

700    1_

$a Trouillet-Assant, Sophie $u Hospices Civils de Lyon, Lyon, France; International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France

700    1_

$a Belot, Alexandre $u Joint Research Unit, Hospices Civils de Lyon-bio Mérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France; International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France $u CNRS UMR 5308, ENS, UCBL, Lyon, France; National Referee Centre for Rheumatic, and Autoimmune and Systemic Diseases in Children (RAISE), Lyon, France; Lyon; Immunopathology Federation LIFE, Hospices Civils de Lyon, Lyon, France

700    1_

$a Saker, Kahina $u Joint Research Unit, Hospices Civils de Lyon-bio Mérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France; International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France

700    1_

$a Garçon, Pierre $u Intensive Care Unit, Grand Hôpital de l'Est Francilien Site de Marne-la-Vallée, Jossigny, France

700    1_

$a Rivière, Jacques G $u Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain

700    1_

$a Lagier, Jean-Christophe $u Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France $u Aix Marseille Université, IRD, APHM, MEPHI, Marseille, France

700    1_

$a Gentile, Stéphanie $u Service d'Evaluation Médicale, Hôpitaux Universitaires de Marseille Assistance Publique Hôpitaux de Marseille (APHM), Marseille, France $u Aix Marseille University, School of Medicine - La Timone Medical Campus, EA 3279: CEReSS - Health Service Research and Quality of Life Center, Marseille, France

700    1_

$a Rosen, Lindsey B $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA

700    1_

$a Shaw, Elana $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA

700    1_

$a Morio, Tomohiro $u Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

700    1_

$a Tanaka, Junko $u Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

700    1_

$a Dalmau, David $u Hospital Universitari Mutua Tarrassa, Tarrasa, Spain

700    1_

$a Tharaux, Pierre-Louis $u Paris Cardiovascular Center, PARCC, Inserm, Université de Paris, Paris, France

700    1_

$a Sene, Damien $u Internal Medicine Department, Lariboisière Hospital, AP-HP, Paris University, Paris, France

700    1_

$a Stepanian, Alain $u Service d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris and EA3518, Institut Universitaire d'Hématologie-Hôpital Saint Louis, Université Paris Diderot, Paris, France

700    1_

$a Megarbane, Bruno $u Réanimation Médicale et Toxicologique, Hôpital Lariboisière (AP-HP), Université Paris-Diderot, INSERM Unité Mixte de Recherche Scientifique (UMRS) 1144

700    1_

$a Triantafyllia, Vasiliki $u Laboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece

700    1_

$a Fekkar, Arnaud $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u Service de Parasitologie-Mycologie, Groupe Hospitalier Pitié Salpêtrière, AP-HP, Paris, France

700    1_

$a Heath, James R $u Institute for Systems Biology, Seattle, WA 98109, USA

700    1_

$a Franco, José Luis $u Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UDEA, Medellín, Colombia

700    1_

$a Anaya, Juan-Manuel $u Center for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia

700    1_

$a Solé-Violán, Jordi $u Critical Care Unit, University Hospital of Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Canary Islands, Spain $u CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain

700    1_

$a Imberti, Luisa $u CREA Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy

700    1_

$a Biondi, Andrea $u Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy

700    1_

$a Bonfanti, Paolo $u Department of Infectious Diseases, San Gerardo Hospital-University of Milano-Bicocca, Monza, Italy

700    1_

$a Castagnoli, Riccardo $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA $u Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy

700    1_

$a Delmonte, Ottavia M $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA

700    1_

$a Zhang, Yu $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA $u NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, USA

700    1_

$a Snow, Andrew L $u Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

700    1_

$a Holland, Steven M $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA

700    1_

$a Biggs, Catherine $u Department of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, BC, Canada

700    1_

$a Moncada-Vélez, Marcela $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA

700    1_

$a Arias, Andrés Augusto $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA $u Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia $u School of Microbiology, University of Antioquia UdeA, Medellin, Colombia

700    1_

$a Lorenzo, Lazaro $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France

700    1_

$a Boucherit, Soraya $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France

700    1_

$a Coulibaly, Boubacar $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France

700    1_

$a Anglicheau, Dany $u Department of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France

700    1_

$a Planas, Anna M $u Institute for Biomedical Research, Spanish Research Council, Barcelona, Spain $u Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

700    1_

$a Haerynck, Filomeen $u Department of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium

700    1_

$a Duvlis, Sotirija $u Faculty of Medical Sciences, University "Goce Delchev", Stip, Republic of Northern Macedonia $u Institute of public health of Republic of North Macedonia

700    1_

$a Nussbaum, Robert L $u Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, USA

700    1_

$a Ozcelik, Tayfun $u Department of Molecular Biology and Genetics, Bilkent University, Bilkent - Ankara, Turkey

700    1_

$a Keles, Sevgi $u Meram Medical Faculty, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey

700    1_

$a Bousfiha, Ahmed A $u Clinical Immunology Unit, Department of Pediatric Infectious Disease, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

700    1_

$a El Bakkouri, Jalila $u Clinical Immunology Unit, Department of Pediatric Infectious Disease, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

700    1_

$a Ramirez-Santana, Carolina $u Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UDEA, Medellín, Colombia $u Center for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia

700    1_

$a Paul, Stéphane $u Department of Immunology, CIC1408, GIMAP CIRI INSERM U1111, University Hospital of Saint-Etienne, Saint-Etienne, France

700    1_

$a Pan-Hammarström, Qiang $u Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden

700    1_

$a Hammarström, Lennart $u Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden

700    1_

$a Dupont, Annabelle $u Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, F-59000 Lille, France

700    1_

$a Kurolap, Alina $u The Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel

700    1_

$a Metz, Christine N $u Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA

700    1_

$a Aiuti, Alessandro $u Pathogenesis and Therapy of Primary Immunodeficiencies Unit, San Raffaele, Milano, Italy

700    1_

$a Casari, Giorgio $u Pathogenesis and Therapy of Primary Immunodeficiencies Unit, San Raffaele, Milano, Italy

700    1_

$a Lampasona, Vito $u Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

700    1_

$a Ciceri, Fabio $u Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy

700    1_

$a Barreiros, Lucila A $u Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

700    1_

$a Dominguez-Garrido, Elena $u Fundación Rioja Salud - Centro de Investigación Biomédica de La Rioja, Logrono, Spain

700    1_

$a Vidigal, Mateus $u University of Sao Paulo, Sao Paulo, Brazil

700    1_

$a Zatz, Mayana $u University of Sao Paulo, Sao Paulo, Brazil

700    1_

$a van de Beek, Diederik $u Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands

700    1_

$a Sahanic, Sabina $u Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria

700    1_

$a Tancevski, Ivan $u Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria

700    1_

$a Stepanovskyy, Yurii $u Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine

700    1_

$a Boyarchuk, Oksana $u Department of Children's Diseases and Pediatric Surgery, I.Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

700    1_

$a Nukui, Yoko $u Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

700    1_

$a Tsumura, Miyuki $u Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

700    1_

$a Vidaur, Loreto $u Intensive Care Department, Donostia University Hospital, San Sebastian, Spain $u Centro de Investigación en Red de Enfermedades Respiratorias-CIBERES - Instituto de Salud Carlos III, Madrid, España

700    1_

$a Tangye, Stuart G $u Garvan Institute of Medical Research, Sydney, Australia

700    1_

$a Burrel, Sonia $u Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Service de Virologie, Paris, France

700    1_

$a Duffy, Darragh $u Translational Immunology Lab, Institut Pasteur

700    1_

$a Quintana-Murci, Lluis $u Human Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, Paris, France $u Chair of Human Genomics and Evolution, Collège de France, Paris, France

700    1_

$a Klocperk, Adam $u Department of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital in Motol, Prague, Czech Republic

700    1_

$a Kann, Nelli Y $u Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

700    1_

$a Shcherbina, Anna $u Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

700    1_

$a Lau, Yu-Lung $u Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong, China

700    1_

$a Leung, Daniel $u Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong, China

700    1_

$a Coulongeat, Matthieu $u Division of Geriatric Medicine, Tours University Medical Center, Tours, France

700    1_

$a Marlet, Julien $u INSERM U1259, MAVIVH, Université de Tours, Tours, France $u Service de Bactériologie-Virologie-Hygiène, CHU de Tours, Tours, France

700    1_

$a Koning, Rutger $u Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands

700    1_

$a Reyes, Luis Felipe $u Department of Microbiology, Universidad de La Sabana, Chia, Colombia $u Department of Critical Care Medicine, Clinica Universidad de La Sabana, Chia, Colombia

700    1_

$a Chauvineau-Grenier, Angélique $u Service de Biologie Médicale, CHI Robert Ballanger, Aulnay sous Bois, France

700    1_

$a Venet, Fabienne $u Laboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France $u EA 7426 « Pathophysiology of Injury-Induced Immunosuppression », Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, Hôpital Edouard Herriot - BioMérieux, Lyon, France

700    1_

$a Monneret, Guillaume $u Laboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France $u EA 7426 « Pathophysiology of Injury-Induced Immunosuppression », Université Claude Bernard Lyon 1 - Hospices Civils de Lyon, Hôpital Edouard Herriot - BioMérieux, Lyon, France

700    1_

$a Nussenzweig, Michel C $u Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA $u Howard Hughes Medical Institute, New York, NY, USA

700    1_

$a Arrestier, Romain $u Service de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique - Hôpitaux de Paris (AP-HP) $u Groupe de Recherche Clinique CARMAS, Faculté de Santé de Créteil, Université Paris Est Créteil, 51, Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil Cedex, France

700    1_

$a Boudhabhay, Idris $u Department of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France

700    1_

$a Baris-Feldman, Hagit $u The Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

700    1_

$a Hagin, David $u Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel $u Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

700    1_

$a Wauters, Joost $u Medical Intensive care Unit, University Hospitals Leuven, Leuven, Belgium

700    1_

$a Meyts, Isabelle $u Laboratory of Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, KU Leuven, Leuven, Belgium $u Department of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center, University Hospitals Leuven, Leuven, Belgium

700    1_

$a Dyer, Adam H $u Department of Age-Related Healthcare, Tallaght University Hospital & Department of Medical Gerontology, School of Medicine, Trinity College Dublin

700    1_

$a Kennelly, Sean P $u Department of Age-Related Healthcare, Tallaght University Hospital & Department of Medical Gerontology, School of Medicine, Trinity College Dublin

700    1_

$a Bourke, Nollaig M $u Department of Medical Gerontology, School of Medicine, Trinity College Dublin

700    1_

$a Halwani, Rabih $u Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates

700    1_

$a Sharif-Askari, Narjes Saheb $u Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates

700    1_

$a Dorgham, Karim $u Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, (CIMI- Paris), Paris, France

700    1_

$a Sallette, Jérome $u Cerba Health Care, Issy-les-Moulineaux, France

700    1_

$a Sedkaoui, Souad Mehlal $u Cerba Health Care, Issy-les-Moulineaux, France

700    1_

$a AlKhater, Suzan $u Department of Pediatrics, King Fahad Hospital of the University, Al-Khobar, Saudi Arabia $u College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

700    1_

$a Rigo-Bonnin, Raúl $u Department of Clinical Laboratory, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain

700    1_

$a Morandeira, Francisco $u Department of Immunology, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain

700    1_

$a Roussel, Lucie $u Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada $u Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada

700    1_

$a Vinh, Donald C $u Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada $u Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada

700    1_

$a Ostrowski, Sisse Rye $u Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

700    1_

$a Condino-Neto, Antonio $u Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

700    1_

$a Prando, Carolina $u Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil

700    1_

$a Bonradenko, Anastasiia $u Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine

700    1_

$a Spaan, András N $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA $u Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands

700    1_

$a Gilardin, Laurent $u Service de Médecine Interne, Hôpital universitaire Jean-Verdier, AP-HP, Bondy, France $u INSERM U1138, Centre de Recherche des Cordeliers, Paris, France

700    1_

$a Fellay, Jacques $u School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland $u Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland $u Swiss Institue of Bioinformatics, Lausanne, Switzerland

700    1_

$a Lyonnet, Stanislas $u Imagine Institute, Université de Paris, INSERM UMR 1163, Paris, France

700    1_

$a Bilguvar, Kaya $u Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA $u Department of Genetics, Yale University School of Medicine, New Haven, CT, USA $u Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA $u Department of Medical Genetics, Acibadem University School of Medicine, Istanbul, Turkey

700    1_

$a Lifton, Richard P $u Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA $u Department of Genetics, Yale University School of Medicine, New Haven, CT, USA $u Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY

700    1_

$a Mane, Shrikant $u Department of Genetics, Yale University School of Medicine, New Haven, CT, USA

700    1_

$a Anderson, Mark S $u Diabetes Center, University of California, San Francisco, CA, USA

700    1_

$a Boisson, Bertrand $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA

700    1_

$a Béziat, Vivien $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France

700    1_

$a Zhang, Shen-Ying $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA

700    1_

$a Vandreakos, Evangelos $u Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

700    1_

$a Hermine, Olivier $u University of Paris, Imagine Institute, Paris, France $u Department of Hematology, Necker Hospital, AP-HP, Paris, France

700    1_

$a Pujol, Aurora $u Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain

700    1_

$a Peterson, Pärt $u Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia

700    1_

$a Mogensen, Trine H $u Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark $u Department of Biomedicine, Aarhus University, Aarhus, Denmark

700    1_

$a Rowen, Lee $u Institute for Systems Biology, Seattle, WA 98109, USA

700    1_

$a Mond, James $u ADMA Biologics Inc., Ramsey NJ

700    1_

$a Debette, Stéphanie $u University of Bordeaux, INSERM, Bordeaux Population Health Center, UMR1219, F-33000 Bordeaux, France $u Bordeaux University Hospital, Department of Neurology, Institute of Neurodegenerative Diseases, F-33000 Bordeaux, France

700    1_

$a de Lamballerie, Xavier $u IHU Méditerranée Infection, Unité des Virus Émergents, UVE: Aix Marseille University, IRD 190, INSERM 1207, Marseille, France

700    1_

$a Duval, Xavier $u Inserm CIC 1425, Paris, France $u Université de Paris, IAME UMR-S 1137, INSERM, Paris, France $u AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France $u AP-HP, Bichat Claude Bernard Hospital, Infectious and Tropical Diseases Department, Paris, France

700    1_

$a Mentré, France $u Inserm CIC 1425, Paris, France $u Université de Paris, IAME UMR-S 1137, INSERM, Paris, France $u AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France

700    1_

$a Zins, Marie $u Université de Paris, Université Paris-Saclay, UVSQ, Inserm UMS11, Villejuif, France

700    1_

$a Soler-Palacin, Pere $u Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain

700    1_

$a Colobran, Roger $u Immunology Division, Genetics Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, UAB, Barcelona, Catalonia, Spain

700    1_

$a Gorochov, Guy $u Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, (CIMI- Paris), Paris, France $u Département d'Immunologie, Assistance Publique Hôpitaux de Paris (AP-HP), Hôpital Pitié-Salpétrière, Paris, France

700    1_

$a Solanich, Xavier $u Department of Internal Medicine, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain

700    1_

$a Susen, Sophie $u Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, F-59000 Lille, France

700    1_

$a Martinez-Picado, Javier $u IrsiCaixa AIDS Research Institute and Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain $u Infectious Diseases and Immunity, Center for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain $u Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

700    1_

$a Raoult, Didier $u Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France $u Aix Marseille Université, IRD, APHM, MEPHI, Marseille, France

700    1_

$a Vasse, Marc $u Service de Biologie Clinique & UMR-S 1176, Hopital Foch, Suresnes, France

700    1_

$a Gregersen, Peter K $u Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA

700    1_

$a Piemonti, Lorenzo $u Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

700    1_

$a Rodríguez-Gallego, Carlos $u Hospital Universitario de Gran Canaria Dr Negrín, Canarian Health System, Canary Islands, Spain $u Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Canary Islands, Spain

700    1_

$a Notarangelo, Luigi D $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA

700    1_

$a Su, Helen C $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA $u Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

700    1_

$a Kisand, Kai $u Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia

700    1_

$a Okada, Satoshi $u Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

700    1_

$a Puel, Anne $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA

700    1_

$a Jouanguy, Emmanuelle $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA

700    1_

$a Rice, Charles M $u Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA

700    1_

$a Tiberghien, Pierre $u Etablissement Français du Sang, La Plaine-St Denis, France $u UMR 1098 RIGHT, Inserm, EFS, Université de Franche-Comté, Besançon, France

700    1_

$a Zhang, Qian $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA

700    1_

$a Cobat, Aurélie $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA

700    1_

$a Abel, Laurent $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA

700    1_

$a Casanova, Jean-Laurent $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. jean-laurent.casanova@rockefeller.edu paul.bastard@institutimagine.org $u University of Paris, Imagine Institute, Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA $u Howard Hughes Medical Institute, New York, NY, USA

710    2_

$a HGID Lab

710    2_

$a COVID Clinicians

710    2_

$a COVID-STORM Clinicians

710    2_

$a NIAID Immune Response to COVID Group

710    2_

$a NH-COVAIR Study Group

710    2_

$a Danish CHGE

710    2_

$a Danish Blood Donor Study

710    2_

$a St. James's Hospital

710    2_

$a SARS CoV2 Interest group

710    2_

$a French COVID Cohort Study Group

710    2_

$a Imagine COVID-Group

710    2_

$a Milieu Intérieur Consortium

710    2_

$a CoV-Contact Cohort

710    2_

$a Amsterdam UMC Covid-19

710    2_

$a Biobank Investigators

710    2_

$a COVID Human Genetic Effort

710    2_

$a CONSTANCES cohort

710    2_

$a 3C-Dijon Study

710    2_

$a Cerba Health-Care

710    2_

$a Etablissement du Sang study group

773    0_

$w MED00205752 $t Science immunology $x 2470-9468 $g Roč. 6, č. 62 (2021)

856    41

$u https://pubmed.ncbi.nlm.nih.gov/34413139 $y Pubmed

910    __

$a ABA008 $b sig $c sign $y p $z 0

990    __

$a 20211013 $b ABA008

991    __

$a 20211026134128 $b ABA008

999    __

$a ok $b bmc $g 1714243 $s 1145612

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2021 $b 6 $c 62 $e 20210819 $i 2470-9468 $m Science immunology $n Sci Immunol $x MED00205752

GRA    __

$a ZIA AI001270 $p Intramural NIH HHS $2 United States

GRA    __

$a UM1 HG006504 $p NHGRI NIH HHS $2 United States

GRA    __

$a P01 AI138398-S1 $p NIH HHS $2 United States

GRA    __

$a 1ZIA AI001265 $p Intramural NIH HHS $2 United States

GRA    __

$p Howard Hughes Medical Institute $2 United States

GRA    __

$a UL1 TR001866 $p NCATS NIH HHS $2 United States

GRA    __

$a 2U19 AI111825 $p NIH HHS $2 United States

GRA    __

$a U24 HG008956 $p NHGRI NIH HHS $2 United States

GRA    __

$a R01 AI088364 $p NIAID NIH HHS $2 United States

GRA    __

$a R01 AI091707-10S1 $p NIH HHS $2 United States

LZP    __

$a Pubmed-20211013