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Analytical Methods for the Determination of Neuroactive Steroids
M. Kaleta, J. Oklestkova, O. Novák, M. Strnad
Language English Country Switzerland
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
IGA_PrF_2021_011
Palacky University
No. CZ.02.1.01/0.0/0.0/16_019/0000827
ERDF project "Plants as a tool for sustainable global development"
NLK
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PubMed
33918915
DOI
10.3390/biom11040553
Knihovny.cz E-resources
- MeSH
- Blood Chemical Analysis methods MeSH
- Mass Spectrometry methods MeSH
- Hormones blood metabolism MeSH
- Immunoassay methods MeSH
- Humans MeSH
- Neurosteroids blood metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Neuroactive steroids are a family of all steroid-based compounds, of both natural and synthetic origin, which can affect the nervous system functions. Their biosynthesis occurs directly in the nervous system (so-called neurosteroids) or in peripheral endocrine tissues (hormonal steroids). Steroid hormone levels may fluctuate due to physiological changes during life and various pathological conditions affecting individuals. A deeper understanding of neuroactive steroids' production, in addition to reliable monitoring of their levels in various biological matrices, may be useful in the prevention, diagnosis, monitoring, and treatment of some neurodegenerative and psychiatric diseases. The aim of this review is to highlight the most relevant methods currently available for analysis of neuroactive steroids, with an emphasis on immunoanalytical methods and gas, or liquid chromatography combined with mass spectrometry.
References provided by Crossref.org
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