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The rDNA Loci-Intersections of Replication, Transcription, and Repair Pathways

I. Goffová, J. Fajkus

. 2021 ; 22 (3) : . [pub] 20210128

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc21026168

Grant support
SYMBIT CZ.02.1.01/0.0/0.0/15_003/0000477 European Regional Development Fund
LTC20003 Ministerstvo Školství, Mládeže a Tělovýchovy

Genes encoding ribosomal RNA (rDNA) are essential for cell survival and are particularly sensitive to factors leading to genomic instability. Their repetitive character makes them prone to inappropriate recombinational events arising from collision of transcriptional and replication machineries, resulting in unstable rDNA copy numbers. In this review, we summarize current knowledge on the structure and organization of rDNA, its role in sensing changes in the genome, and its linkage to aging. We also review recent findings on the main factors involved in chromatin assembly and DNA repair in the maintenance of rDNA stability in the model plants Arabidopsis thaliana and the moss Physcomitrella patens, providing a view across the plant evolutionary tree.

References provided by Crossref.org

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