-
Je něco špatně v tomto záznamu ?
Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients
M. Kroupa, S. Rachakonda, V. Vymetalkova, K. Tomasova, V. Liska, S. Vodenkova, A. Cumova, A. Rossnerova, L. Vodickova, K. Hemminki, P. Soucek, R. Kumar, P. Vodicka
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1996 do Před 1 rokem
Open Access Digital Library
od 1996-01-01
Medline Complete (EBSCOhost)
od 1996-01-01 do Před 1 rokem
PubMed
33367858
DOI
10.1093/mutage/geaa030
Knihovny.cz E-zdroje
- MeSH
- alely MeSH
- celogenomová asociační studie MeSH
- dospělí MeSH
- genetická predispozice k nemoci genetika MeSH
- genetická variace genetika MeSH
- genotyp MeSH
- homeostáza telomer genetika MeSH
- jednonukleotidový polymorfismus genetika MeSH
- leukocyty mononukleární MeSH
- leukocyty patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lymfatické metastázy genetika patologie MeSH
- nádorové biomarkery genetika MeSH
- nádory prsu krev genetika patologie MeSH
- RNA genetika MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- staging nádorů MeSH
- telomerasa genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Disruption of telomere length (TL) homeostasis in peripheral blood lymphocytes has been previously assessed as a potential biomarker of breast cancer (BC) risk. The present study addressed the relationship between lymphocyte TL (LTL), prognosis and clinicopathological features in the BC patients since these associations are insufficiently explored at present. LTL was measured in 611 BC patients and 154 healthy controls using the monochrome multiplex quantitative Polymerase Chain Reaction assay. In addition, we genotyped nine TL-associated single-nucleotide polymorphisms that had been identified through genome-wide association studies. Our results showed that the patients had significantly (P = 0.001, Mann-Whitney U-test) longer LTL [median (interquartile range); 1.48 (1.22-1.78)] than the healthy controls [1.27 (0.97-1.82)]. Patients homozygous (CC) for the common allele of hTERT rs2736108 or the variant allele (CC) of hTERC rs16847897 had longer LTL. The latter association remained statistically significant in the recessive genetic model after the Bonferroni correction (P = 0.004, Wilcoxon two-sample test). We observed no association between LTL and overall survival or relapse-free survival of the patients. LTL did not correlate with cancer staging based on Union for International Cancer Control (UICC), The tumor node metastasis (TNM) staging system classification, tumour grade or molecular BC subtypes. Overall, we observed an association between long LTL and BC disease and an association of the hTERC rs16847897 CC genotype with increased LTL. However, no association between LTL, clinicopathological features and survival of the patients was found.
Division of Cancer Epidemiology German Cancer Research Center Im Neuenheimer Feld Heidelberg Germany
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21026321
- 003
- CZ-PrNML
- 005
- 20211026133007.0
- 007
- ta
- 008
- 211013s2020 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1093/mutage/geaa030 $2 doi
- 035 __
- $a (PubMed)33367858
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Kroupa, Michal $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Husova, Pilsen, Czech Republic
- 245 10
- $a Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients / $c M. Kroupa, S. Rachakonda, V. Vymetalkova, K. Tomasova, V. Liska, S. Vodenkova, A. Cumova, A. Rossnerova, L. Vodickova, K. Hemminki, P. Soucek, R. Kumar, P. Vodicka
- 520 9_
- $a Disruption of telomere length (TL) homeostasis in peripheral blood lymphocytes has been previously assessed as a potential biomarker of breast cancer (BC) risk. The present study addressed the relationship between lymphocyte TL (LTL), prognosis and clinicopathological features in the BC patients since these associations are insufficiently explored at present. LTL was measured in 611 BC patients and 154 healthy controls using the monochrome multiplex quantitative Polymerase Chain Reaction assay. In addition, we genotyped nine TL-associated single-nucleotide polymorphisms that had been identified through genome-wide association studies. Our results showed that the patients had significantly (P = 0.001, Mann-Whitney U-test) longer LTL [median (interquartile range); 1.48 (1.22-1.78)] than the healthy controls [1.27 (0.97-1.82)]. Patients homozygous (CC) for the common allele of hTERT rs2736108 or the variant allele (CC) of hTERC rs16847897 had longer LTL. The latter association remained statistically significant in the recessive genetic model after the Bonferroni correction (P = 0.004, Wilcoxon two-sample test). We observed no association between LTL and overall survival or relapse-free survival of the patients. LTL did not correlate with cancer staging based on Union for International Cancer Control (UICC), The tumor node metastasis (TNM) staging system classification, tumour grade or molecular BC subtypes. Overall, we observed an association between long LTL and BC disease and an association of the hTERC rs16847897 CC genotype with increased LTL. However, no association between LTL, clinicopathological features and survival of the patients was found.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a alely $7 D000483
- 650 _2
- $a nádorové biomarkery $x genetika $7 D014408
- 650 _2
- $a nádory prsu $x krev $x genetika $x patologie $7 D001943
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a genetická predispozice k nemoci $x genetika $7 D020022
- 650 _2
- $a genetická variace $x genetika $7 D014644
- 650 _2
- $a celogenomová asociační studie $7 D055106
- 650 _2
- $a genotyp $7 D005838
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a leukocyty $x patologie $7 D007962
- 650 _2
- $a leukocyty mononukleární $7 D007963
- 650 _2
- $a lymfatické metastázy $x genetika $x patologie $7 D008207
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a staging nádorů $7 D009367
- 650 _2
- $a jednonukleotidový polymorfismus $x genetika $7 D020641
- 650 _2
- $a RNA $x genetika $7 D012313
- 650 _2
- $a telomerasa $x genetika $7 D019098
- 650 _2
- $a homeostáza telomer $x genetika $7 D059505
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Rachakonda, Sivaramakrishna $u Division of Functional Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, Heidelberg, Germany
- 700 1_
- $a Vymetalkova, Veronika $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Husova, Pilsen, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Albertov, Prague, Czech Republic
- 700 1_
- $a Tomasova, Kristyna $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Husova, Pilsen, Czech Republic
- 700 1_
- $a Liska, Vaclav $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Husova, Pilsen, Czech Republic
- 700 1_
- $a Vodenkova, Sona $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska, Prague, Czech Republic $u Department of Medical Genetics, Third Faculty of Medicine, Charles University, Ruska, Prague, Czech Republic
- 700 1_
- $a Cumova, Andrea $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska, Prague, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Albertov, Prague, Czech Republic
- 700 1_
- $a Rossnerova, Andrea $u Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska, Prague, Czech Republic
- 700 1_
- $a Vodickova, Ludmila $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Husova, Pilsen, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Albertov, Prague, Czech Republic
- 700 1_
- $a Hemminki, Kari $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Husova, Pilsen, Czech Republic $u Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, Heidelberg, Germany
- 700 1_
- $a Soucek, Pavel $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Husova, Pilsen, Czech Republic
- 700 1_
- $a Kumar, Rajiv $u Division of Functional Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, Heidelberg, Germany
- 700 1_
- $a Vodicka, Pavel $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Husova, Pilsen, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Albertov, Prague, Czech Republic
- 773 0_
- $w MED00003429 $t Mutagenesis $x 1464-3804 $g Roč. 35, č. 6 (2020), s. 491-497
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33367858 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20211013 $b ABA008
- 991 __
- $a 20211026133014 $b ABA008
- 999 __
- $a ok $b bmc $g 1715137 $s 1146828
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 35 $c 6 $d 491-497 $e 20201231 $i 1464-3804 $m Mutagenesis $n Mutagenesis $x MED00003429
- LZP __
- $a Pubmed-20211013