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Parthenogenesis as a Solution to Hybrid Sterility: The Mechanistic Basis of Meiotic Distortions in Clonal and Sterile Hybrids
D. Dedukh, Z. Majtánová, A. Marta, M. Pšenička, J. Kotusz, J. Klíma, D. Juchno, A. Boron, K. Janko
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1916 to 6 months ago
Freely Accessible Science Journals
from 1916 to 1 year ago
Europe PubMed Central
from 1916 to 1 year ago
ProQuest Central
from 2004-10-01 to 2020-12-31
Open Access Digital Library
from 1916-01-01
Open Access Digital Library
from 1916-01-01
Medline Complete (EBSCOhost)
from 1916-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2004-10-01 to 2020-12-31
Family Health Database (ProQuest)
from 2004-10-01 to 2020-12-31
Public Health Database (ProQuest)
from 2004-10-01 to 2020-12-31
- MeSH
- Biological Evolution MeSH
- Chromosomes MeSH
- Hybrid Cells cytology physiology MeSH
- Infertility genetics MeSH
- Meiosis * MeSH
- Parthenogenesis * MeSH
- Fishes genetics physiology MeSH
- Genetic Speciation * MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Hybrid sterility is a hallmark of speciation, but the underlying molecular mechanisms remain poorly understood. Here, we report that speciation may regularly proceed through a stage at which gene flow is completely interrupted, but hybrid sterility occurs only in male hybrids whereas female hybrids reproduce asexually. We analyzed gametogenic pathways in hybrids between the fish species Cobitis elongatoides and C. taenia, and revealed that male hybrids were sterile owing to extensive asynapsis and crossover reduction among heterospecific chromosomal pairs in their gametes, which was subsequently followed by apoptosis. We found that polyploidization allowed pairing between homologous chromosomes and therefore partially rescued the bivalent formation and crossover rates in triploid hybrid males. However, it was not sufficient to overcome sterility. In contrast, both diploid and triploid hybrid females exhibited premeiotic genome endoreplication, thereby ensuring proper bivalent formation between identical chromosomal copies. This endoreplication ultimately restored female fertility but it simultaneously resulted in the obligate production of clonal gametes, preventing any interspecific gene flow. In conclusion, we demonstrate that the emergence of asexuality can remedy hybrid sterility in a sex-specific manner and contributes to the speciation process.
Department of Biology and Ecology Faculty of Science University of Ostrava 710 00 Czech Republic
Institute of Zoology Academy of Science of Moldova Chisinau MD 2028 Republic of Moldova
Museum of Natural History University of Wrocław 50 335 Poland
References provided by Crossref.org
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