• Je něco špatně v tomto záznamu ?

Recoverable Bismuth-Based Microrobots: Capture, Transport, and On-Demand Release of Heavy Metals and an Anticancer Drug in Confined Spaces

SM Beladi-Mousavi, B Khezri, L Krejcova, Z Heger, Z Sofer, AC Fisher, M Pumera

. 2019 ; 11 (14) : 13359-13369.

Jazyk angličtina Země Spojené státy americké

Perzistentní odkaz   https://www.medvik.cz/link/bmc21027559

Grantová podpora
NV15-28334A MZ0 CEP - Centrální evidence projektů

Self-propelled microrobots are seen as the next step of micro- and nanotechnology. The biomedical and environmental applications of these robots in the real world need their motion in the confined environments, such as in veins or spaces between the grains of soil. Here, self-propelled trilayer microrobots have been prepared using electrodeposition techniques, coupling unique properties of green bismuth (Bi) with a layered crystal structure, magnetic nickel (Ni), and a catalytic platinum (Pt) layer. These Bi-based microrobots are investigated as active self-propelled platforms that can load, transfer, and release both doxorubicin (DOX), as a widely used anticancer drug, and arsenic (As) and chromium (Cr), as hazardous heavy metals. The significantly high loading capability for such variable cargoes is due to the high surface area provided by the rhombohedral layered crystal structure of bismuth, as well as the defects introduced through the oxide layer formed on the surface of bismuth. The drug release is based on an ultrafast electroreductive mechanism in which the electron injection into microrobots and consequently into the loaded objects causes an electrostatic repulsion between them and thus an ultrafast release of the loaded cargos. Remarkably, we have presented magnetic control of the Bi-based microrobots inside a microfluidic system equipped with an electrochemical setup as a proof-of-concept to demonstrate (i) heavy metals/DOX loading, (ii) a targeted transport system, (iii) the on-demand release mechanism, and (iv) the recovery of the robots for further usage.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21027559
003      
CZ-PrNML
005      
20220404160446.0
007      
ta
008      
211103s2019 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1021/acsami.8b19408 $2 doi
035    __
$a (PubMed)30925065
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Beladi-Mousavi, Seyyed Mohsen $u Beladi-Mousavi, Seyyed Mohsen. Center for the Advanced Functional Nanorobots, Department of Inorganic Chemistry, University of Chemistry and Technology, Technicka 5, 166 28 Prague, Czech Republic.
245    10
$a Recoverable Bismuth-Based Microrobots: Capture, Transport, and On-Demand Release of Heavy Metals and an Anticancer Drug in Confined Spaces / $c SM Beladi-Mousavi, B Khezri, L Krejcova, Z Heger, Z Sofer, AC Fisher, M Pumera
520    9_
$a Self-propelled microrobots are seen as the next step of micro- and nanotechnology. The biomedical and environmental applications of these robots in the real world need their motion in the confined environments, such as in veins or spaces between the grains of soil. Here, self-propelled trilayer microrobots have been prepared using electrodeposition techniques, coupling unique properties of green bismuth (Bi) with a layered crystal structure, magnetic nickel (Ni), and a catalytic platinum (Pt) layer. These Bi-based microrobots are investigated as active self-propelled platforms that can load, transfer, and release both doxorubicin (DOX), as a widely used anticancer drug, and arsenic (As) and chromium (Cr), as hazardous heavy metals. The significantly high loading capability for such variable cargoes is due to the high surface area provided by the rhombohedral layered crystal structure of bismuth, as well as the defects introduced through the oxide layer formed on the surface of bismuth. The drug release is based on an ultrafast electroreductive mechanism in which the electron injection into microrobots and consequently into the loaded objects causes an electrostatic repulsion between them and thus an ultrafast release of the loaded cargos. Remarkably, we have presented magnetic control of the Bi-based microrobots inside a microfluidic system equipped with an electrochemical setup as a proof-of-concept to demonstrate (i) heavy metals/DOX loading, (ii) a targeted transport system, (iii) the on-demand release mechanism, and (iv) the recovery of the robots for further usage.
650    02
$a antitumorózní látky $x chemie $x terapeutické užití $7 D000970
650    12
$a bismut $x chemie $x toxicita $7 D001729
650    02
$a chrom $x chemie $x toxicita $7 D002857
650    02
$a uzavřené prostory $7 D020378
650    12
$a doxorubicin $x chemie $7 D004317
650    02
$a uvolňování léčiv $7 D065546
650    02
$a lidé $7 D006801
650    02
$a těžké kovy $x chemie $x toxicita $7 D019216
650    02
$a nanotechnologie $x trendy $7 D036103
650    12
$a nádory $x farmakoterapie $x patologie $7 D009369
650    02
$a platina $x chemie $x toxicita $7 D010984
700    1_
$a Khezri, Bahareh
700    1_
$a Krejčová, Ludmila $7 _AN074759
700    1_
$a Heger, Zbyněk $7 xx0276759
700    1_
$a Sofer, Zdeněk $7 ntk2016922574
700    1_
$a Fisher, Adrian C.
700    1_
$a Pumera, Martin, $d 1974- $7 uk2015866290
773    0_
$t Acs Applied Materials & Interfaces $g Roč. 11, č. 14 (2019), s. 13359-13369 $p ACS Appl Mater Interfaces $x 1944-8244 $w MED00179503
773    0_
$p ACS Appl Mater Interfaces $g 11(14):13359-13369, 2019 Apr 10
910    __
$a ABA008 $y p $b sig $z 0
990    __
$a 20211103092722 $b ABA008
991    __
$a 20220404160443 $b ABA008
999    __
$a ok $b bmc $g 1718445 $s 1148084
BAS    __
$a 3
BMC    __
$a 2019 $b 11 $c 14 $d 13359-13369 $x MED00179503 $i 1944-8244 $m ACS applied materials & interfaces
GRA    __
$a NV15-28334A $p MZ0
LZP    __
$a 2021-granty

Najít záznam

Citační ukazatele

Nahrávání dat ...

    Možnosti archivace