-
Je něco špatně v tomto záznamu ?
Role of cytochrome c oxidase nuclear-encoded subunits in health and disease
K. Čunátová, D. P. Reguera, J. Houštěk, T. Mráček, P. Pecina
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články, přehledy
NLK
Directory of Open Access Journals
od 1991
Free Medical Journals
od 1998
PubMed Central
od 2020
ProQuest Central
od 2005-01-01
Medline Complete (EBSCOhost)
od 2006-01-01
Nursing & Allied Health Database (ProQuest)
od 2005-01-01
Health & Medicine (ProQuest)
od 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
od 1998
- MeSH
- buněčné jádro enzymologie genetika MeSH
- genom MeSH
- lidé MeSH
- mitochondriální nemoci enzymologie patologie MeSH
- mitochondrie enzymologie genetika MeSH
- orgánová specificita MeSH
- podjednotky proteinů MeSH
- respirační komplex IV genetika metabolismus MeSH
- signální transdukce MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Cytochrome c oxidase (COX), the terminal enzyme of mitochondrial electron transport chain, couples electron transport to oxygen with generation of proton gradient indispensable for the production of vast majority of ATP molecules in mammalian cells. The review summarizes current knowledge of COX structure and function of nuclear-encoded COX subunits, which may modulate enzyme activity according to various conditions. Moreover, some nuclear-encoded subunits posess tissue-specific and development-specific isoforms, possibly enabling fine-tuning of COX function in individual tissues. The importance of nuclear-encoded subunits is emphasized by recently discovered pathogenic mutations in patients with severe mitopathies. In addition, proteins substoichiometrically associated with COX were found to contribute to COX activity regulation and stabilization of the respiratory supercomplexes. Based on the summarized data, a model of three levels of quaternary COX structure is postulated. Individual structural levels correspond to subunits of the i) catalytic center, ii) nuclear-encoded stoichiometric subunits and iii) associated proteins, which may constitute several forms of COX with varying composition and differentially regulated function.
Citace poskytuje Crossref.org
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21028150
- 003
- CZ-PrNML
- 005
- 20250205082228.0
- 007
- ta
- 008
- 211105s2020 xr d f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.33549/physiolres.934446 $2 doi
- 035 __
- $a (PubMed)33129245
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Čunátová, Kristýna $7 xx0328253 $u Department of Bioenergetics, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
- 245 10
- $a Role of cytochrome c oxidase nuclear-encoded subunits in health and disease / $c K. Čunátová, D. P. Reguera, J. Houštěk, T. Mráček, P. Pecina
- 504 __
- $a Literatura
- 520 9_
- $a Cytochrome c oxidase (COX), the terminal enzyme of mitochondrial electron transport chain, couples electron transport to oxygen with generation of proton gradient indispensable for the production of vast majority of ATP molecules in mammalian cells. The review summarizes current knowledge of COX structure and function of nuclear-encoded COX subunits, which may modulate enzyme activity according to various conditions. Moreover, some nuclear-encoded subunits posess tissue-specific and development-specific isoforms, possibly enabling fine-tuning of COX function in individual tissues. The importance of nuclear-encoded subunits is emphasized by recently discovered pathogenic mutations in patients with severe mitopathies. In addition, proteins substoichiometrically associated with COX were found to contribute to COX activity regulation and stabilization of the respiratory supercomplexes. Based on the summarized data, a model of three levels of quaternary COX structure is postulated. Individual structural levels correspond to subunits of the i) catalytic center, ii) nuclear-encoded stoichiometric subunits and iii) associated proteins, which may constitute several forms of COX with varying composition and differentially regulated function.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a buněčné jádro $x enzymologie $x genetika $7 D002467
- 650 _2
- $a respirační komplex IV $x genetika $x metabolismus $7 D003576
- 650 _2
- $a genom $7 D016678
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mitochondrie $x enzymologie $x genetika $7 D008928
- 650 _2
- $a mitochondriální nemoci $x enzymologie $x patologie $7 D028361
- 650 _2
- $a orgánová specificita $7 D009928
- 650 _2
- $a podjednotky proteinů $7 D021122
- 650 _2
- $a signální transdukce $7 D015398
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Pajuelo Reguera, David $7 _AN081851 $u Department of Bioenergetics, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
- 700 1_
- $a Houštěk, Josef, $d 1947- $7 xx0030591 $u Department of Bioenergetics, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
- 700 1_
- $a Mráček, Tomáš $7 xx0122128 $u Department of Bioenergetics, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
- 700 1_
- $a Pecina, Petr $7 xx0141218 $u Department of Bioenergetics, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
- 773 0_
- $w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 69, č. 6 (2020), s. 947-965
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33129245 $y Pubmed
- 910 __
- $a ABA008 $b A 4120 $c 266 $y p $z 0
- 990 __
- $a 20211105 $b ABA008
- 991 __
- $a 20250205082225 $b ABA008
- 999 __
- $a ok $b bmc $g 1728757 $s 1148695
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 69 $c 6 $d 947-965 $e 20201102 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
- LZP __
- $b NLK118 $a Pubmed-20211105