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Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment-A Pilot Study
J. Brož, MD. Campbell, J. Urbanová, MA. Nunes, L. Brunerová, D. Rahelić, D. Janíčková Žďárská, A. Taniwall, M. Brabec, V. Berka, J. Michalec, J. Polák
Language English Country Switzerland
Document type Journal Article
Grant support
00064203
Ministry of Health, Czech Republic
NLK
Free Medical Journals
from 2009
PubMed Central
from 2009
Europe PubMed Central
from 2009
ProQuest Central
from 2009-01-01
Open Access Digital Library
from 2009-01-01
Open Access Digital Library
from 2009-01-01
Health & Medicine (ProQuest)
from 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2009
PubMed
34836420
DOI
10.3390/nu13114165
Knihovny.cz E-resources
- MeSH
- Administration, Oral MeSH
- Exercise * MeSH
- Bicycling MeSH
- Diabetes Mellitus, Type 1 blood drug therapy MeSH
- Adult MeSH
- Glucose administration & dosage MeSH
- Hypoglycemia drug therapy MeSH
- Insulin blood MeSH
- Blood Glucose analysis MeSH
- Humans MeSH
- Pilot Projects MeSH
- Heart Rate MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min-1 (minimum: 0.07, maximum: 0.17 mmol/L·min-1). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min-1 (minimum: 0.06, maximum: 0.19 mmol/L·min-1). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.
Department of Internal Medicine 2nd Medical Faculty Charles University 150 00 Prague Czech Republic
Faculty of Medicine Josip Juraj Strossmayer University of Osijek 310 00 Osijek Croatia
Institute of Computer Science Academy of Science of the Czech Republic 110 00 Prague Czech Republic
School of Food Science and Nutrition University of Leeds Leeds LS2 9JT UK
School of Medicine University of Zagreb 100 00 Zagreb Croatia
References provided by Crossref.org
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- $a The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min-1 (minimum: 0.07, maximum: 0.17 mmol/L·min-1). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min-1 (minimum: 0.06, maximum: 0.19 mmol/L·min-1). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.
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