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A cell-ECM mechanism for connecting the ipsilateral eye to the brain

J. Su, U. Sabbagh, Y. Liang, L. Olejníková, KG. Dixon, AL. Russell, J. Chen, YA. Pan, JW. Triplett, MA. Fox

. 2021 ; 118 (42) : . [pub] 20211019

Language English Country United States

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc22003447

Grant support
F99 NS113459 NINDS NIH HHS - United States
R21 EY030568 NEI NIH HHS - United States
R21 EY029874 NEI NIH HHS - United States
R25 NS105141 NINDS NIH HHS - United States
K00 NS113459 NINDS NIH HHS - United States
R01 EY025627 NEI NIH HHS - United States
R01 EY021222 NEI NIH HHS - United States

E-resources Online Full text

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Links

PubMed 34654745
DOI 10.1073/pnas.2104343118
Knihovny.cz E-resources

Information about features in the visual world is parsed by circuits in the retina and is then transmitted to the brain by distinct subtypes of retinal ganglion cells (RGCs). Axons from RGC subtypes are stratified in retinorecipient brain nuclei, such as the superior colliculus (SC), to provide a segregated relay of parallel and feature-specific visual streams. Here, we sought to identify the molecular mechanisms that direct the stereotyped laminar targeting of these axons. We focused on ipsilateral-projecting subtypes of RGCs (ipsiRGCs) whose axons target a deep SC sublamina. We identified an extracellular glycoprotein, Nephronectin (NPNT), whose expression is restricted to this ipsiRGC-targeted sublamina. SC-derived NPNT and integrin receptors expressed by ipsiRGCs are both required for the targeting of ipsiRGC axons to the deep sublamina of SC. Thus, a cell-extracellular matrix (ECM) recognition mechanism specifies precise laminar targeting of ipsiRGC axons and the assembly of eye-specific parallel visual pathways.

References provided by Crossref.org

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