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The Effect of Partly Replacing Vegetable Fat with Bovine Milk Fat in Infant Formula on Postprandial Lipid and Energy Metabolism: A Proof-of-principle Study in Healthy Young Male Adults
JHJ. Hageman, B. Erdõs, J. Keijer, M. Adriaens, B. de Wit, B. Stañková, E. Tvrzická, ICW. Arts, AG. Nieuwenhuizen
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, randomizované kontrolované studie
PubMed
33682997
DOI
10.1002/mnfr.202000848
Knihovny.cz E-zdroje
- MeSH
- chylomikrony krev MeSH
- dietní tuky * MeSH
- dvojitá slepá metoda MeSH
- energetický metabolismus * MeSH
- ketolátky krev MeSH
- klinické křížové studie MeSH
- kojenec MeSH
- lidé MeSH
- lipidy krev MeSH
- mastné kyseliny analýza MeSH
- metabolismus lipidů * MeSH
- mladý dospělý MeSH
- mléko * MeSH
- náhražky mateřského mléka * MeSH
- postprandiální období fyziologie MeSH
- zelenina MeSH
- zvířata MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
SCOPE: Infant formula (IF) uses besides vegetable fats also bovine milk fat, which differs in triacylglycerol (TAG) structure. Furthermore, it differs in fatty acid (FA) composition. Whether changing fat source in IF affects postprandial energy metabolism, lipemic response, and blood lipid profile is unknown. METHODS AND RESULTS: A proof-of-principle study, with a randomized controlled double-blind cross-over design, is conducted. Twenty healthy male adults consumed drinks with either 100% vegetable fat (VEG) or 67% bovine milk fat and 33% vegetable fat (BOV), on 2 separate days. For a detailed insight in the postprandial responses, indirect calorimetry is performed continuously, and venous blood samples are taken every 30 min, until 5 h postprandially. No differences in postprandial energy metabolism, serum lipids, lipoprotein, or chylomicron concentrations are observed between drinks. After consumption of VEG-drink, C18:2n-6 in serum increased. Observed differences in chylomicron FA profile reflect differences in initial FA profile of test drinks. Serum ketone bodies concentrations increase following consumption of BOV-drink. CONCLUSIONS: The use of bovine milk fat in IF does neither affect postprandial energy metabolism nor lipemic response in healthy adults, but alters postprandial FA profiles and ketone metabolism. Whether the exact same effects occur in infants requires experimental verification.
4th Department of Internal Medicine 1st Faculty of Medicine Charles University Prague Czech Republic
FrieslandCampina Stationsplein 1 Amersfoort 3818 LE Netherlands
Human and Animal Physiology Wageningen University de Elst 1 Wageningen 6708 WD Netherlands
Maastricht Centre for Systems Biology Maastricht University Maastricht 6200 MD Netherlands
Citace poskytuje Crossref.org
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