-
Je něco špatně v tomto záznamu ?
CT evaluated sarcopenia signals: Shorter survival for small cell lung cancer patients
A. Pekařová, M. Pekař, D. Daniš, Z. Nováková
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 1991
Free Medical Journals
od 1998
PubMed Central
od 2020
ProQuest Central
od 2005-01-01
Medline Complete (EBSCOhost)
od 2006-01-01
Nursing & Allied Health Database (ProQuest)
od 2005-01-01
Health & Medicine (ProQuest)
od 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
od 1998
- MeSH
- bederní svaly diagnostické zobrazování patofyziologie MeSH
- časové faktory MeSH
- lidé středního věku MeSH
- lidé MeSH
- malobuněčný karcinom plic diagnostické zobrazování mortalita patofyziologie MeSH
- nádory plic diagnostické zobrazování mortalita patofyziologie MeSH
- počítačová rentgenová tomografie * MeSH
- prediktivní hodnota testů MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- sarkopenie diagnostické zobrazování mortalita MeSH
- senioři MeSH
- složení těla MeSH
- zdravotní stav MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Sarcopenia is an independent risk factor for morbidity and mortality in patients suffering from small cell lung cancer (SCLC), however, a universal indicator of sarcopenia usable in clinical practice is still missing. A novel indicator for describing the severity of cancer could be helpful in tailoring the anti-tumor therapy. The aim of this study was to evaluate the computed tomography (CT) scans of total muscle area and radiation attenuation in patients suffering from small cell lung cancer. We used staging CT scans performed at the time of diagnosis to measure total muscle area (TMA) and average psoas density (PD) at level of the 3rd lumbar vertebra. TMA and PD were statistically evaluated in association with overall survival and disease staging. We used Mann-Whitney test and Spearman ́s correlation coefficient for statistical testing and p-value under 0.05 was considered statistically significant. Retrospectively we examined 47 patients suffering from SCLC (mean age 65.05+/-7.3 years, BMI 23.97+/-4.4 kg/m2, BSA 1.77+/-0.2 m2, 30-day mortality was 4.3 % with 10 months median survival). As sarcopenia was pointed TMA under 55 and 39 cm2/m2 for men and women respectively. The sarcopenic patients had significantly shorter median survival (7 vs. 11 months, p=0.05). We observed a significant relationship between survival and performance status (Spearman ́s correlation, R=-0.39, p=0.05). The patients were divided into two groups according to the extensive (ED, n=34) or limited (LD, n=13) form of the disease. We observed significant difference in PD (42.49+/-6.1 vs. 47.67+/-4.5 HU, p=0.006) between ED vs. LD groups.
Department of Physiology Faculty of Medicine Masaryk University Brno Czech Republic
Department of Surgery Vitkovice Hospital Ostrava Czech Republic
Lung disease Department Faculty Hospital Ostrava Czech Republic
The Jackson Laboratory for Genomic Medicine Famington CT USA
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22009467
- 003
- CZ-PrNML
- 005
- 20250625131840.0
- 007
- ta
- 008
- 220419s2021 xr ad f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.33549/physiolres.934816 $2 doi
- 035 __
- $a (PubMed)35099256
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Pekařová, Anna $u Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic $7 xx0240510 $u Lung disease Department, Faculty Hospital, Ostrava, Czech Republic
- 245 10
- $a CT evaluated sarcopenia signals: Shorter survival for small cell lung cancer patients / $c A. Pekařová, M. Pekař, D. Daniš, Z. Nováková
- 520 9_
- $a Sarcopenia is an independent risk factor for morbidity and mortality in patients suffering from small cell lung cancer (SCLC), however, a universal indicator of sarcopenia usable in clinical practice is still missing. A novel indicator for describing the severity of cancer could be helpful in tailoring the anti-tumor therapy. The aim of this study was to evaluate the computed tomography (CT) scans of total muscle area and radiation attenuation in patients suffering from small cell lung cancer. We used staging CT scans performed at the time of diagnosis to measure total muscle area (TMA) and average psoas density (PD) at level of the 3rd lumbar vertebra. TMA and PD were statistically evaluated in association with overall survival and disease staging. We used Mann-Whitney test and Spearman ́s correlation coefficient for statistical testing and p-value under 0.05 was considered statistically significant. Retrospectively we examined 47 patients suffering from SCLC (mean age 65.05+/-7.3 years, BMI 23.97+/-4.4 kg/m2, BSA 1.77+/-0.2 m2, 30-day mortality was 4.3 % with 10 months median survival). As sarcopenia was pointed TMA under 55 and 39 cm2/m2 for men and women respectively. The sarcopenic patients had significantly shorter median survival (7 vs. 11 months, p=0.05). We observed a significant relationship between survival and performance status (Spearman ́s correlation, R=-0.39, p=0.05). The patients were divided into two groups according to the extensive (ED, n=34) or limited (LD, n=13) form of the disease. We observed significant difference in PD (42.49+/-6.1 vs. 47.67+/-4.5 HU, p=0.006) between ED vs. LD groups.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a složení těla $7 D001823
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a zdravotní stav $7 D006304
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a nádory plic $x diagnostické zobrazování $x mortalita $x patofyziologie $7 D008175
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a prediktivní hodnota testů $7 D011237
- 650 _2
- $a prognóza $7 D011379
- 650 _2
- $a bederní svaly $x diagnostické zobrazování $x patofyziologie $7 D016658
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a rizikové faktory $7 D012307
- 650 _2
- $a sarkopenie $x diagnostické zobrazování $x mortalita $7 D055948
- 650 _2
- $a malobuněčný karcinom plic $x diagnostické zobrazování $x mortalita $x patofyziologie $7 D055752
- 650 _2
- $a časové faktory $7 D013997
- 650 12
- $a počítačová rentgenová tomografie $7 D014057
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Pekař, Matej $u Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Department of Surgery, Vitkovice Hospital, Ostrava, Czech Republic $7 xx0240508
- 700 1_
- $a Daniš, Dušan $7 xx0063658 $u The Jackson Laboratory for Genomic Medicine, Famington, CT, USA
- 700 1_
- $a Nováková, Zuzana, $d 1961- $7 mzk2002103492 $u Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
- 773 0_
- $w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 70, Suppl. 3 (2021), s. S381-S386
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35099256 $y Pubmed
- 910 __
- $a ABA008 $b A 4120 $c 266 $y p $z 0
- 990 __
- $a 20220419 $b ABA008
- 991 __
- $a 20250625131835 $b ABA008
- 999 __
- $a ok $b bmc $g 1796975 $s 1160665
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 70 $c Suppl. 3 $d S381-S386 $e 20211231 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
- LZP __
- $b NLK124 $a Pubmed-20220419