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Bile Acids Transporters of Enterohepatic Circulation for Targeted Drug Delivery

R. Durník, L. Šindlerová, P. Babica, O. Jurček

. 2022 ; 27 (9) : . [pub] 20220505

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy, systematický přehled

Perzistentní odkaz   https://www.medvik.cz/link/bmc22018463

Grantová podpora
665860 Horizon 2020 and innovation programme Marie Sklodowska-Curie, South Moravian Region
LM2018127 CIISB, Instruct-CZ Centre, supported by MEYS CR
2020 Central European Institute of Technology
LM2018121 RECETOX RI, MEYS CR
CZ.02.1.01/0.0/0.0/17_043/0009632 CETOCOEN EXCELLENCE, Operational Programme Research, Development and Innovation
857560 European Union's Horizon 2020 research and innovation programme

Bile acids (BAs) are important steroidal molecules with a rapidly growing span of applications across a variety of fields such as supramolecular chemistry, pharmacy, and biomedicine. This work provides a systematic review on their transport processes within the enterohepatic circulation and related processes. The focus is laid on the description of specific or less-specific BA transport proteins and their localization. Initially, the reader is provided with essential information about BAs' properties, their systemic flow, metabolism, and functions. Later, the transport processes are described in detail and schematically illustrated, moving step by step from the liver via bile ducts to the gallbladder, small intestine, and colon; this description is accompanied by descriptions of major proteins known to be involved in BA transport. Spillage of BAs into systemic circulation and urine excretion are also discussed. Finally, the review also points out some of the less-studied areas of the enterohepatic circulation, which can be crucial for the development of BA-related drugs, prodrugs, and drug carrier systems.

Citace poskytuje Crossref.org

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