• Je něco špatně v tomto záznamu ?

VEILND (Video Endoscopic Inguinal Lymph Node Dissection) with Florescence Indocyanine Green (ICG): A Novel Technique to Identify the Sentinel Lymph Node in Men with ≥pT1G2 and cN0 Penile Cancer

M. Hora, I. Trávníček, Š. Nykodýmová, J. Ferda, D. Kacerovská, K. Michalová, O. Hes, S. Minhas

. 2021 ; 2021 (-) : 5575730. [pub] 20211029

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22019654

Introduction: In men with ≥pT1G2 cN0, penile cancer lymph node sampling is recommended with either (1) scintigraphically labelled Dynamic sentinel lymph node biopsy (DSLNB) or (2) modified inguinal lymph node dissection (MILND). Although DSLNB is a minimally invasive technique, the false negative rate can be about 10%, and a further operative procedure is required if positive. Open MILND is a diagnostic and therapeutic option but has a much higher morbidity. A potential compromise is the technique of LND-VEILND (video endoscopic inguinal LND) that can be combined with ICG florescence marking of sentinel lymph node (SLN). We present a pilot study of ICG-VEILND. The aim was to validate the applicability of a combination ICG marking of SLN in VEILND (to increase probability to excise SLN) and determine the optimal timing and dosage of ICG. Materials and Methods: 15 patients with VEILND (24 groins) underwent ICG application with fluorescence near-infrared (NIR 803⟶830 nm) detection. ICG is applied subcutaneously adjacent to the penile cancer or residual stump of penis or suprapubic region (in a history of total penectomy: 5 cases). The dose of 1.25 mg (ICG) was applied in one case with invisible SLN, the dose of 2.5 mg in 1 mL in 8 cases, and 5 mg in the remaining 6 patients (10 groins). Results: Failure of marking SLN with ICG occurred in 25.0% of cases (6/24): due to application of 1.25 mg ICG, extensive metastasis to SLN, in 4 cases, the cause was unknown (16.7%, 4/24). In the short follow-up period, no local recurrence was seen in the pN0 ICG group. Conclusion: Fluorescence infrared image with ICG dye increases the probability of removal of the SLN during VEILND. The dose of ICG is 2.5 (5) mg diluted in 1 ml and can be applied preoperatively even in the suprapubic region in men with a history of total penectomy, with an unexplainable failure of ICG marking in 16.7%.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22019654
003      
CZ-PrNML
005      
20220804135852.0
007      
ta
008      
220720s2021 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1155/2021/5575730 $2 doi
035    __
$a (PubMed)34803546
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Hora, Milan $u Department of Urology, University Hospital Plzeň and Faculty of Medicine in Plzeň, Charles University, Pilsen, Czech Republic $1 https://orcid.org/0000000250613687 $7 mzk2004258359
245    10
$a VEILND (Video Endoscopic Inguinal Lymph Node Dissection) with Florescence Indocyanine Green (ICG): A Novel Technique to Identify the Sentinel Lymph Node in Men with ≥pT1G2 and cN0 Penile Cancer / $c M. Hora, I. Trávníček, Š. Nykodýmová, J. Ferda, D. Kacerovská, K. Michalová, O. Hes, S. Minhas
520    9_
$a Introduction: In men with ≥pT1G2 cN0, penile cancer lymph node sampling is recommended with either (1) scintigraphically labelled Dynamic sentinel lymph node biopsy (DSLNB) or (2) modified inguinal lymph node dissection (MILND). Although DSLNB is a minimally invasive technique, the false negative rate can be about 10%, and a further operative procedure is required if positive. Open MILND is a diagnostic and therapeutic option but has a much higher morbidity. A potential compromise is the technique of LND-VEILND (video endoscopic inguinal LND) that can be combined with ICG florescence marking of sentinel lymph node (SLN). We present a pilot study of ICG-VEILND. The aim was to validate the applicability of a combination ICG marking of SLN in VEILND (to increase probability to excise SLN) and determine the optimal timing and dosage of ICG. Materials and Methods: 15 patients with VEILND (24 groins) underwent ICG application with fluorescence near-infrared (NIR 803⟶830 nm) detection. ICG is applied subcutaneously adjacent to the penile cancer or residual stump of penis or suprapubic region (in a history of total penectomy: 5 cases). The dose of 1.25 mg (ICG) was applied in one case with invisible SLN, the dose of 2.5 mg in 1 mL in 8 cases, and 5 mg in the remaining 6 patients (10 groins). Results: Failure of marking SLN with ICG occurred in 25.0% of cases (6/24): due to application of 1.25 mg ICG, extensive metastasis to SLN, in 4 cases, the cause was unknown (16.7%, 4/24). In the short follow-up period, no local recurrence was seen in the pN0 ICG group. Conclusion: Fluorescence infrared image with ICG dye increases the probability of removal of the SLN during VEILND. The dose of ICG is 2.5 (5) mg diluted in 1 ml and can be applied preoperatively even in the suprapubic region in men with a history of total penectomy, with an unexplainable failure of ICG marking in 16.7%.
650    _2
$a lidé $7 D006801
650    _2
$a indokyanová zeleň $7 D007208
650    _2
$a lymfadenektomie $x metody $7 D008197
650    _2
$a lymfatické uzliny $x patologie $7 D008198
650    _2
$a mužské pohlaví $7 D008297
650    12
$a nádory penisu $x diagnostické zobrazování $x patologie $x chirurgie $7 D010412
650    _2
$a pilotní projekty $7 D010865
650    12
$a sentinelová uzlina $x diagnostické zobrazování $x chirurgie $7 D000071036
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Trávníček, Ivan $u Department of Urology, University Hospital Plzeň and Faculty of Medicine in Plzeň, Charles University, Pilsen, Czech Republic $1 https://orcid.org/0000000349182936
700    1_
$a Nykodýmová, Štěpánka $u Department of Urology, University Hospital Plzeň and Faculty of Medicine in Plzeň, Charles University, Pilsen, Czech Republic
700    1_
$a Ferda, Jiří $u Department of Radiology, University Hospital Plzeň and Faculty of Medicine in Plzeň, Charles University, Pilsen, Czech Republic $1 https://orcid.org/0000000323440511
700    1_
$a Kacerovská, Denisa $u Department of Pathology, University Hospital Plzeň and Faculty of Medicine in Plzeň, Charles University, Pilsen, Czech Republic $1 https://orcid.org/000000031893535X
700    1_
$a Michalová, Květoslava $u Department of Pathology, University Hospital Plzeň and Faculty of Medicine in Plzeň, Charles University, Pilsen, Czech Republic $1 https://orcid.org/0000000332316870 $7 xx0236038
700    1_
$a Hes, Ondřej $u Department of Pathology, University Hospital Plzeň and Faculty of Medicine in Plzeň, Charles University, Pilsen, Czech Republic $1 https://orcid.org/0000000196577557
700    1_
$a Minhas, Suks $u Imperial College Healthcare, London, UK $1 https://orcid.org/000000016516619X
773    0_
$w MED00180205 $t Contrast media & molecular imaging $x 1555-4317 $g Roč. 2021, č. - (2021), s. 5575730
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34803546 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220720 $b ABA008
991    __
$a 20220804135846 $b ABA008
999    __
$a ok $b bmc $g 1823029 $s 1170897
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 2021 $c - $d 5575730 $e 20211029 $i 1555-4317 $m Contrast Media Mol Imaging $n Contrast Media Mol Imaging $x MED00180205
LZP    __
$a Pubmed-20220720

Najít záznam

Citační ukazatele

Možnosti archivace