• Je něco špatně v tomto záznamu ?

Detailed insight into chromium species released from failed CoCrMo implants: Ex vivo periprosthetic tissues study

R. Pechancová, J. Gallo, D. Baron, D. Milde, P. Antal, Z. Slobodová, K. Lemr, T. Pluháček

. 2023 ; 111 (2) : 271-283. [pub] 20220817

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22031959

This unique study provides information on Cr species and their distribution in periprosthetic tissues of patients with metal-on-polyethylene joint implants. Co-Cr-Mo alloy has been widely used in joint replacement and represents a source of metal derived species. In the case of chromium, previous studies on periprosthetic tissues revealed mainly Cr(III) distribution, whereas the potential release of carcinogenic Cr(VI) species has been still a subject of debate. Here, an analytical approach utilizing speciation and fractionation was developed to analyze periprosthetic tissue samples collected from wide range of patients with failed total hip or knee replacements. The results reveal that Cr(III) is mainly released in the form of insoluble CrPO4 and Cr2 O3 particles. The highest Cr contents were found in periprosthetic tissues of patients suffering from aseptic loosening and having more Cr-based implants in the body. Cr species penetrated tissue layers, but their levels decreased with the distance from an implant. The detailed speciation/fractionation study carried out using the set of consecutive periprosthetic tissues of a patient with extensive metallosis showed the presence of trace amounts of free Cr(III), nanoparticles, and metal-protein complexes, but the majority of Cr still occurred in CrPO4 form. Carcinogenic Cr(VI) species were not detected. Up to date, there is no published human tissue study focused on the detailed speciation of both soluble and insoluble Cr-based species in the context of failing total hip and knee replacements.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22031959
003      
CZ-PrNML
005      
20230131151243.0
007      
ta
008      
230120s2023 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1002/jbm.b.35149 $2 doi
035    __
$a (PubMed)36507699
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Pechancová, Radka $u Department of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic
245    10
$a Detailed insight into chromium species released from failed CoCrMo implants: Ex vivo periprosthetic tissues study / $c R. Pechancová, J. Gallo, D. Baron, D. Milde, P. Antal, Z. Slobodová, K. Lemr, T. Pluháček
520    9_
$a This unique study provides information on Cr species and their distribution in periprosthetic tissues of patients with metal-on-polyethylene joint implants. Co-Cr-Mo alloy has been widely used in joint replacement and represents a source of metal derived species. In the case of chromium, previous studies on periprosthetic tissues revealed mainly Cr(III) distribution, whereas the potential release of carcinogenic Cr(VI) species has been still a subject of debate. Here, an analytical approach utilizing speciation and fractionation was developed to analyze periprosthetic tissue samples collected from wide range of patients with failed total hip or knee replacements. The results reveal that Cr(III) is mainly released in the form of insoluble CrPO4 and Cr2 O3 particles. The highest Cr contents were found in periprosthetic tissues of patients suffering from aseptic loosening and having more Cr-based implants in the body. Cr species penetrated tissue layers, but their levels decreased with the distance from an implant. The detailed speciation/fractionation study carried out using the set of consecutive periprosthetic tissues of a patient with extensive metallosis showed the presence of trace amounts of free Cr(III), nanoparticles, and metal-protein complexes, but the majority of Cr still occurred in CrPO4 form. Carcinogenic Cr(VI) species were not detected. Up to date, there is no published human tissue study focused on the detailed speciation of both soluble and insoluble Cr-based species in the context of failing total hip and knee replacements.
650    _2
$a lidé $7 D006801
650    12
$a kyčelní protézy $7 D006622
650    _2
$a selhání protézy $7 D011475
650    _2
$a chrom $7 D002857
650    12
$a totální endoprotéza kolene $7 D019645
650    _2
$a kovy $7 D008670
650    12
$a náhrada kyčelního kloubu $7 D019644
655    _2
$a časopisecké články $7 D016428
700    1_
$a Gallo, Jiří $u Department of Orthopedics, Faculty of Medicine and Dentistry, Palacký University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic
700    1_
$a Baron, Daniel $u Department of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic
700    1_
$a Milde, David $u Department of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic $1 https://orcid.org/0000000191216728
700    1_
$a Antal, Peter $u Department of Inorganic Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic
700    1_
$a Slobodová, Zuzana $u Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic
700    1_
$a Lemr, Karel $u Department of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic $u Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Pluháček, Tomáš $u Department of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic $1 https://orcid.org/0000000274170016
773    0_
$w MED00007497 $t Journal of biomedical materials research. Part B, Applied biomaterials $x 1552-4981 $g Roč. 111, č. 2 (2023), s. 271-283
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36507699 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230120 $b ABA008
991    __
$a 20230131151239 $b ABA008
999    __
$a ok $b bmc $g 1891014 $s 1183294
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 111 $c 2 $d 271-283 $e 20220817 $i 1552-4981 $m Journal of biomedical materials research. Part B, Applied biomaterials $n J Biomed Mater Res $x MED00007497
LZP    __
$a Pubmed-20230120

Najít záznam

Citační ukazatele

Možnosti archivace