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Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry
LR. Lopes, MA. Losi, N. Sheikh, C. Laroche, P. Charron, J. Gimeno, JP. Kaski, AP. Maggioni, L. Tavazzi, E. Arbustini, D. Brito, J. Celutkiene, A. Hagege, A. Linhart, J. Mogensen, JM. Garcia-Pinilla, T. Ripoll-Vera, H. Seggewiss, E. Villacorta, A....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
MR/T005181/1
Medical Research Council - United Kingdom
Medical Research Council - United Kingdom
British Heart Foundation - United Kingdom
NLK
ProQuest Central
od 2016-10-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2016-10-01 do Před 1 rokem
PubMed
35138368
DOI
10.1093/ehjqcco/qcac006
Knihovny.cz E-zdroje
- MeSH
- dysfunkce levé srdeční komory * komplikace MeSH
- hypertenze * komplikace MeSH
- hypertrofická kardiomyopatie * komplikace epidemiologie genetika MeSH
- kardiomyopatie * komplikace MeSH
- kardiovaskulární nemoci * epidemiologie genetika komplikace MeSH
- lidé MeSH
- obezita komplikace epidemiologie MeSH
- rizikové faktory kardiovaskulárních chorob MeSH
- rizikové faktory MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
AIMS: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. METHODS AND RESULTS: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. CONCLUSION: Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.
CCUL Faculdade de Medicina Universidade de Lisboa Av Prof Egas Moniz MB Lisbon 1649 028 Portugal
Centre for Inherited Cardiovascular Diseases Great Ormond Street Hospital London WC1N 3JH UK
Department of Cardiology Odense University Hospital J B Winsløws Vej 4 Odense 5000 Denmark
EORP European Society of Cardiology Sophia Antipolis France
Hospital Clínico Universitario Virgen de la Arrixaca Ctra Madrid Cartagena Murcia 30120 El Spain
Institute of Cardiovascular Science University College London Gower St London WC1E 6BT UK
Maria Cecilia Hospital GVM Care and Research Via Corriera 1 Cotignola 48033 RA Italy
Member of National Centers of expertise for familial cardiopathies CIBERCV Salamanca Spain
Serviço de Cardiologia Centro Hospitalar Universitário Lisboa Norte Lisbon 1169 050 Portugal
Serviço de Cardiologia Hospital Garcia de Orta Av Torrado da Silva Almada 2805 267 Portugal
Sorbonne Université Inserm UMR1166 15 21 Rue de l'École de Médecine Paris 75006 France
St Bartholomew's Hospital Barts Heart Centre Barts Health NHS Trust Whitechapel Rd London E1 1BB UK
State Research Institute Centre for Innovative Medicine Vilnius Lithuania
Citace poskytuje Crossref.org
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