-
Je něco špatně v tomto záznamu ?
The impact of vaccination on the burden of invasive pneumococcal disease from a nationwide surveillance program in Lebanon: an unexpected increase in mortality driven by non-vaccine serotypes
L. Reslan, N. Youssef, CF. Boutros, A. Assaf-Casals, D. Fayad, S. Khafaja, F. Akl, M. Finianos, AA. Rizk, R. Shaker, A. Zaghlout, M. Lteif, B. El Hafi, MB. Moumneh, R. Feghali, S. Ghanem, T. Jisr, G. Karayakoupoglou, M. Naboulsi, M. Hamze, S....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- heptavalentní konjugovaná pneumokoková vakcína MeSH
- incidence MeSH
- kojenec MeSH
- lidé MeSH
- pneumokokové infekce * epidemiologie prevence a kontrola MeSH
- pneumokokové vakcíny MeSH
- séroskupina MeSH
- Streptococcus pneumoniae MeSH
- vakcinace MeSH
- vakcíny konjugované MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Libanon MeSH
BACKGROUND: The impact of pneumococcal conjugate vaccines (PCVs) on the burden of invasive pneumococcal disease (IPD) and serotype distribution was examined across age groups from data collected by the Lebanese Inter-Hospital Pneumococcal Surveillance Program. METHODS: Between 2005 and 2020, 593 invasive Streptococcus pneumoniae isolates were collected from 79 hospitals throughout Lebanon. Serotypes and antimicrobial resistance (AMR) profiles were identified, and trends compared over 3 eras: PCV7, post-PCV7/ pre-PCV13, and PCV13 eras. RESULTS: The prevalence of PCV7 serotypes decreased significantly from 43.6% in the PCV7 era to 17.8% during the PCV13 era (p<0.001). PCV13-only serotypes remained stable in the PCV13 compared to the post-PCV7 eras, especially serotypes 1 and 3, whereas non-vaccine types (NVT) increased throughout the study period, especially 24 and 16F. The mortality rate increased substantially from 12.5% (PCV7 era) to 24.8% (PCV13 era). A significant decrease in AMR was observed across the three study eras. CONCLUSION: PCVs substantially impacted IPD and AMR in vaccinated and unvaccinated populations despite an increase in mortality driven by NVT. Broadening the recommendation of vaccination to include older age-groups, using higher valency vaccines, and implementing stringent antimicrobial stewardship are likely to further impact the burden of IPD.
Biomedical Center Faculty of Medicine Charles University Pilsen Czech Republic
Department of Laboratory Medicine Al Rassoul Al Azam Beirut Lebanon
Department of Laboratory Medicine Bahman Hospital Lebanon
Department of Laboratory Medicine Bellevue Medical Center Mansourieh Lebanon
Department of Laboratory Medicine Centre Hospitalier du Nord Zgharta Lebanon
Department of Laboratory Medicine Dar El Shifa Tripoli Lebanon
Department of Laboratory Medicine Hammoud Hospital University Medical Center Saida Lebanon
Department of Laboratory Medicine Haykal Hospital Tripoli Lebanon
Department of Laboratory Medicine Labib Medical Center Saida Lebanon
Department of Laboratory Medicine Monla Hospital Tripoli Lebanon
Department of Laboratory Medicine New Mazloum Hospital Tripoli Lebanon
Department of Laboratory Medicine Rafik Hariri University Hospital Beirut Lebanon
Department of Microbiology El Youssef Hospital Center Halba Lebanon
Department of Microbiology Nini Hospital Tripoli Lebanon
Department of Pediatrics Makassed General Hospital Beirut Lebanon
Department of Pediatrics Saint Georges Hospital University Medical Center Achrafieh Beirut Lebanon
Epidemiological Surveillance Unit Ministry of Public Health Beirut Lebanon
General Director Lebanese Ministry of Public Health Beirut Lebanon
Keserwan Medical Center Jounieh Mount Lebanon Lebanon
Laboratory medicine and transfusion medicine department Makassed General Hospital Beirut Lebanon
PHC Department Lebanese Ministry of Public Health Global Health Team of Experts Lebanon
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22032335
- 003
- CZ-PrNML
- 005
- 20230131151418.0
- 007
- ta
- 008
- 230120s2022 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1080/14760584.2022.2143349 $2 doi
- 035 __
- $a (PubMed)36342411
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Reslan, Lina $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon
- 245 14
- $a The impact of vaccination on the burden of invasive pneumococcal disease from a nationwide surveillance program in Lebanon: an unexpected increase in mortality driven by non-vaccine serotypes / $c L. Reslan, N. Youssef, CF. Boutros, A. Assaf-Casals, D. Fayad, S. Khafaja, F. Akl, M. Finianos, AA. Rizk, R. Shaker, A. Zaghlout, M. Lteif, B. El Hafi, MB. Moumneh, R. Feghali, S. Ghanem, T. Jisr, G. Karayakoupoglou, M. Naboulsi, M. Hamze, S. Samad, E. Khoury, R. Sarraf, M. Osman, E. Bou Raad, H. El Amin, I. Abadi, H. Abdo, M. Chedid, F. Chamseddine, A. Barakat, M. Houmani, A. Haddad, G. Abdel Nour, JE. Mokhbat, Z. Daoud, M. El-Zaatari, E. Salem Sokhn, N. Ghosn, W. Ammar, R. Hamadeh, GM. Matar, GF. Araj, GS. Dbaibo
- 520 9_
- $a BACKGROUND: The impact of pneumococcal conjugate vaccines (PCVs) on the burden of invasive pneumococcal disease (IPD) and serotype distribution was examined across age groups from data collected by the Lebanese Inter-Hospital Pneumococcal Surveillance Program. METHODS: Between 2005 and 2020, 593 invasive Streptococcus pneumoniae isolates were collected from 79 hospitals throughout Lebanon. Serotypes and antimicrobial resistance (AMR) profiles were identified, and trends compared over 3 eras: PCV7, post-PCV7/ pre-PCV13, and PCV13 eras. RESULTS: The prevalence of PCV7 serotypes decreased significantly from 43.6% in the PCV7 era to 17.8% during the PCV13 era (p<0.001). PCV13-only serotypes remained stable in the PCV13 compared to the post-PCV7 eras, especially serotypes 1 and 3, whereas non-vaccine types (NVT) increased throughout the study period, especially 24 and 16F. The mortality rate increased substantially from 12.5% (PCV7 era) to 24.8% (PCV13 era). A significant decrease in AMR was observed across the three study eras. CONCLUSION: PCVs substantially impacted IPD and AMR in vaccinated and unvaccinated populations despite an increase in mortality driven by NVT. Broadening the recommendation of vaccination to include older age-groups, using higher valency vaccines, and implementing stringent antimicrobial stewardship are likely to further impact the burden of IPD.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a kojenec $7 D007223
- 650 _2
- $a séroskupina $7 D065288
- 650 _2
- $a heptavalentní konjugovaná pneumokoková vakcína $7 D000069443
- 650 12
- $a pneumokokové infekce $x epidemiologie $x prevence a kontrola $7 D011008
- 650 _2
- $a pneumokokové vakcíny $7 D022242
- 650 _2
- $a Streptococcus pneumoniae $7 D013296
- 650 _2
- $a vakcíny konjugované $7 D018074
- 650 _2
- $a vakcinace $7 D014611
- 650 _2
- $a incidence $7 D015994
- 651 _2
- $a Libanon $x epidemiologie $7 D007861
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Youssef, Nour $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon $u Department of Pediatrics and Adolescent Medicine, American University of Beirut, Faculty of Medicine, Beirut, Lebanon
- 700 1_
- $a Boutros, Celina F $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon $1 https://orcid.org/0000000177898478
- 700 1_
- $a Assaf-Casals, Aia $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon $u Department of Pediatrics and Adolescent Medicine, American University of Beirut, Faculty of Medicine, Beirut, Lebanon
- 700 1_
- $a Fayad, Danielle $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon
- 700 1_
- $a Khafaja, Sarah $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon $u Department of Pediatrics and Adolescent Medicine, American University of Beirut, Faculty of Medicine, Beirut, Lebanon
- 700 1_
- $a Akl, Fata $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon
- 700 1_
- $a Finianos, Marc $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon $u Department of Microbiology, Faculty of Medicine, and University Hospital in Pilsen, Charles University, Pilsen, Czech Republic $u Biomedical Center, Faculty of Medicine, Charles University, Pilsen, Czech Republic
- 700 1_
- $a Rizk, Amena A $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon
- 700 1_
- $a Shaker, Rouba $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon $u Department of Pediatrics and Adolescent Medicine, American University of Beirut, Faculty of Medicine, Beirut, Lebanon
- 700 1_
- $a Zaghlout, Alissar $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon
- 700 1_
- $a Lteif, Mireille $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon
- 700 1_
- $a El Hafi, Bassam $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon $u Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon $1 https://orcid.org/0000000332772948
- 700 1_
- $a Moumneh, Mohammad Bahij $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon
- 700 1_
- $a Feghali, Rita $u Department of Laboratory Medicine, Rafik Hariri University Hospital, Beirut, Lebanon
- 700 1_
- $a Ghanem, Soha $u Department of Pediatrics, Makassed General Hospital, Beirut, Lebanon $u Department of Pediatrics, Saint Georges Hospital University Medical Center, Achrafieh, Beirut, Lebanon
- 700 1_
- $a Jisr, Tamima $u Laboratory medicine and transfusion medicine department, Makassed General Hospital, Beirut, Lebanon
- 700 1_
- $a Karayakoupoglou, Gilbert $u Department of Laboratory Medicine, Haykal Hospital, Tripoli, Lebanon
- 700 1_
- $a Naboulsi, Malak $u Department of Laboratory Medicine, Haykal Hospital, Tripoli, Lebanon
- 700 1_
- $a Hamze, Monzer $u Department of Microbiology, Nini Hospital, Tripoli, Lebanon
- 700 1_
- $a Samad, Salam $u Department of Laboratory Medicine, Centre Hospitalier du Nord, Zgharta, Lebanon
- 700 1_
- $a Khoury, Elie $u Department of Laboratory Medicine, Centre Hospitalier du Nord, Zgharta, Lebanon
- 700 1_
- $a Sarraf, Ricardo $u Department of Laboratory Medicine, Monla Hospital, Tripoli, Lebanon
- 700 1_
- $a Osman, Marwan $u Department of Microbiology, El-Youssef Hospital Center, Halba, Lebanon $u Department of Public and Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA $1 https://orcid.org/0000000262352760
- 700 1_
- $a Bou Raad, Elie $u Department of Microbiology, El-Youssef Hospital Center, Halba, Lebanon
- 700 1_
- $a El Amin, Hadi $u Department of Microbiology, El-Youssef Hospital Center, Halba, Lebanon
- 700 1_
- $a Abadi, Ibrahim $u Department of Laboratory Medicine, Al Rassoul Al Azam, Beirut, Lebanon
- 700 1_
- $a Abdo, Hicham $u Department of Laboratory Medicine, Dar El Shifa, Tripoli, Lebanon
- 700 1_
- $a Chedid, Marwan $u Department of Laboratory Medicine, New Mazloum Hospital, Tripoli, Lebanon
- 700 1_
- $a Chamseddine, Fatima $u Department of Laboratory Medicine, Bahman Hospital, Lebanon
- 700 1_
- $a Barakat, Angelique $u Department of Laboratory Medicine, Bellevue Medical Center, Mansourieh, Lebanon
- 700 1_
- $a Houmani, Mohammad $u Department of Laboratory Medicine, Labib Medical Center, Saida, Lebanon
- 700 1_
- $a Haddad, Antoine $u Department of Clinical Pathology and Blood Bank, Sacre Coeur Hospital, Lebanese University, Mount Lebanon, Lebanon
- 700 1_
- $a Abdel Nour, Georges $u Department of Laboratory Medicine, Notre Dame des Secours University Hospital Center, Jbeil, Mount Lebanon, Lebanon
- 700 1_
- $a Mokhbat, Jacques E $u Department of Internal Medicine, Division of Infectious Diseases, Lebanese American of Beirut Medical Center-Rizk Hospital, Achrafieh, Beirut, Lebanon
- 700 1_
- $a Daoud, Ziad $u Keserwan Medical Center, Jounieh, Mount Lebanon, Lebanon $u Department of Clinical Microbiology and Infection Prevention, College of Medicine, Central Michigan University and Michigan Health Clinic, Michigan, USA $u Department of Laboratory Medicine, Saint Georges Hospital University Medical Center, Achrafieh, Saida, Lebanon
- 700 1_
- $a El-Zaatari, Mohamad $u Department of Laboratory Medicine, Hammoud Hospital University Medical Center, Saida, Lebanon
- 700 1_
- $a Salem Sokhn, Elie $u Department of Laboratory Medicine, Lebanese Hospital Geitaoui-University Medical Center (UMC), Achrafieh, Beirut, Lebanon $u Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon
- 700 1_
- $a Ghosn, Nada $u Epidemiological Surveillance Unit, Ministry of Public Health, Beirut, Lebanon
- 700 1_
- $a Ammar, Walid $u General Director, Lebanese Ministry of Public Health, Beirut, Lebanon
- 700 1_
- $a Hamadeh, Randa $u PHC Department, Lebanese Ministry of Public Health. Global Health Team of Experts (GHTE), Lebanon
- 700 1_
- $a Matar, Ghassan M $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon $u Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
- 700 1_
- $a Araj, George F $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon $u Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
- 700 1_
- $a Dbaibo, Ghassan S $u Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon $u Department of Pediatrics and Adolescent Medicine, American University of Beirut, Faculty of Medicine, Beirut, Lebanon $1 https://orcid.org/0000000258135878
- 773 0_
- $w MED00174438 $t Expert review of vaccines $x 1744-8395 $g Roč. 21, č. 12 (2022), s. 1905-1921
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/36342411 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230120 $b ABA008
- 991 __
- $a 20230131151412 $b ABA008
- 999 __
- $a ok $b bmc $g 1891221 $s 1183670
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2022 $b 21 $c 12 $d 1905-1921 $e 20221117 $i 1744-8395 $m Expert review of vaccines $n Expert Rev Vaccines $x MED00174438
- LZP __
- $a Pubmed-20230120
