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Prediction of Sudden Cardiac Arrest After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy: ASA-SCARRE Risk Score
J. Veselka, M. Liebregts, R. Cooper, L. Faber, J. Januska, M. Kashtanov, KH. Tesarkova, PR. Hansen, H. Seggewiss, E. Shloydo, K. Popov, E. Hansvenclova, E. Polakova, J. Ten Berg, RH. Stables, J. Jarkovsky, J. Bonaventura
Language English Country United States
Document type Journal Article
NLK
ProQuest Central
from 2012-08-15 to 2 months ago
Nursing & Allied Health Database (ProQuest)
from 2012-08-15 to 2 months ago
Health & Medicine (ProQuest)
from 2012-08-15 to 2 months ago
- MeSH
- Ablation Techniques * MeSH
- Adult MeSH
- Ethanol therapeutic use MeSH
- Cardiomyopathy, Hypertrophic * complications surgery MeSH
- Cardiac Surgical Procedures * MeSH
- Middle Aged MeSH
- Humans MeSH
- Death, Sudden, Cardiac epidemiology etiology prevention & control MeSH
- Risk Factors MeSH
- Aged MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
This study aimed to derive a new score, the Alcohol Septal Ablation-Sudden Cardiac ARREst (ASA-SCARRE) risk score, that can be easily used to evaluate the risk of sudden cardiac arrest events (sudden cardiac death, resuscitation, or appropriate implantable cardioverter-defibrillator discharge) after alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy. We analyzed 1,834 patients from the Euro-ASA registry (49% men, mean age 57 ± 14 years) who were followed up for 5.0 ± 4.3 years (9,202 patient-years) after ASA. A total of 65 patients (3.5%) experienced sudden cardiac arrest events, translating to 0.72 events per 100 patient-years. The independent predictors of sudden cardiac arrest events were septum thickness before ASA (hazard ratio 1.09 per 1 mm, 95% confidence interval 1.04 to 1.14, p <0.001) and left ventricular outflow tract (LVOT) gradient at the last clinical checkup (hazard ratio 1.01 per 1 mm Hg, 95% confidence interval 1.01 to 1.02, p = 0.002). The following ASA-SCARRE risk scores were derived and independently predicted long-term risk of sudden cardiac arrest events: "0" for both LVOT gradient <30 mmHg and baseline septum thickness <20 mm; "1" for LVOT gradient ≥30 mm Hg or baseline septum thickness ≥20 mm; and "2" for both LVOT gradient ≥30 mm Hg and baseline septum thickness ≥20 mm. The C statistic of the ASA-SCARRE risk score was 0.684 (SE 0.030). In conclusion, the ASA-SCARRE risk score may be a useful and easily available clinical tool to predict risk of sudden cardiac arrest events after ASA in patients with hypertrophic obstructive cardiomyopathy.
Cardiocentre Podlesi Trinec Czech Republic
Comprehensive Heart Failure Center University Clinic Wuerzburg Wuerzburg Germany
Department of Cardiology City Hospital No 2 St Petersburg Russian Federation
Department of Cardiology Herlev and Gentofte Hospital Hellerup Denmark
Department of Cardiology Ruhr University Bochum Bochum Germany
Department of Cardiology St Antonius Hospital Nieuwegein Nieuwegein The Netherlands
References provided by Crossref.org
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- $a Veselka, Josef $u Department of Cardiology, University Hospital Motol, Second Medical School, Charles University, Prague, Czech Republic. Electronic address: veselka.josef@seznam.cz
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- $a This study aimed to derive a new score, the Alcohol Septal Ablation-Sudden Cardiac ARREst (ASA-SCARRE) risk score, that can be easily used to evaluate the risk of sudden cardiac arrest events (sudden cardiac death, resuscitation, or appropriate implantable cardioverter-defibrillator discharge) after alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy. We analyzed 1,834 patients from the Euro-ASA registry (49% men, mean age 57 ± 14 years) who were followed up for 5.0 ± 4.3 years (9,202 patient-years) after ASA. A total of 65 patients (3.5%) experienced sudden cardiac arrest events, translating to 0.72 events per 100 patient-years. The independent predictors of sudden cardiac arrest events were septum thickness before ASA (hazard ratio 1.09 per 1 mm, 95% confidence interval 1.04 to 1.14, p <0.001) and left ventricular outflow tract (LVOT) gradient at the last clinical checkup (hazard ratio 1.01 per 1 mm Hg, 95% confidence interval 1.01 to 1.02, p = 0.002). The following ASA-SCARRE risk scores were derived and independently predicted long-term risk of sudden cardiac arrest events: "0" for both LVOT gradient <30 mmHg and baseline septum thickness <20 mm; "1" for LVOT gradient ≥30 mm Hg or baseline septum thickness ≥20 mm; and "2" for both LVOT gradient ≥30 mm Hg and baseline septum thickness ≥20 mm. The C statistic of the ASA-SCARRE risk score was 0.684 (SE 0.030). In conclusion, the ASA-SCARRE risk score may be a useful and easily available clinical tool to predict risk of sudden cardiac arrest events after ASA in patients with hypertrophic obstructive cardiomyopathy.
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