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Association of Cerebrovascular and Alzheimer Disease Biomarkers With Cholinergic White Matter Degeneration in Cognitively Unimpaired Individuals

N. Cedres, D. Ferreira, M. Nemy, A. Machado, JB. Pereira, S. Shams, LO. Wahlund, A. Zettergren, O. Stepankova, L. Vyslouzilova, M. Eriksdotter, S. Teipel, MJ. Grothe, K. Blennow, H. Zetterberg, M. Schöll, S. Kern, I. Skoog, E. Westman

Cedres, Nira
Autor Cedres, Nira ORCID From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Ferreira, Daniel
Autor Ferreira, Daniel ORCID From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. daniel.ferreira.padilla@ki.se
Nemy, Milan
Autor Nemy, Milan From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Machado, Alejandra
Autor Machado, Alejandra From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Pereira, Joana B
Autor Pereira, Joana B From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Shams, Sara
Autor Shams, Sara From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Wahlund, Lars-Olof
Autor Wahlund, Lars-Olof From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Zettergren, Anna
Autor Zettergren, Anna From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Stepankova, Olga
Autor Stepankova, Olga From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Vyslouzilova, Lenka
Autor Vyslouzilova, Lenka From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Eriksdotter, Maria
Autor Eriksdotter, Maria From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Teipel, Stefan
Autor Teipel, Stefan From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Grothe, Michel J
Autor Grothe, Michel J From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Blennow, Kaj
Autor Blennow, Kaj ORCID From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Zetterberg, Henrik
Autor Zetterberg, Henrik ORCID From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Schöll, Michael
Autor Schöll, Michael ORCID From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Kern, Silke
Autor Kern, Silke From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Skoog, Ingmar
Autor Skoog, Ingmar From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Westman, Eric
Autor Westman, Eric ORCID From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden Department of Radiology (D.F.), Mayo Clinic, Rochester, MN Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London Dementia Research Institute at UCL (H.Z.), London, UK Hong Kong Center for Neurodegenerative Diseases (H.Z.), China Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden Dementia Research Centre (M.S.), Institute of Neurology, University College London and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

Neurology. 2022 ; 99 (15) : e1619-e1629. [pub] 20220802

ISSN 1526-632X
Medvik
Zdroj

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz https://www.medvik.cz/link/bmc22033091

PubMed 35918153
DOI 10.1212/wnl.0000000000200930
Knihovny.cz E-zdroje

MeSH
Alzheimerova nemoc * diagnostické zobrazování genetika metabolismus MeSH
amyloid metabolismus MeSH
amyloidní beta-protein metabolismus MeSH
amyloidogenní proteiny metabolismus MeSH
amyloidóza * MeSH
apolipoprotein E4 genetika MeSH
bílá hmota * patologie MeSH
biologické markery MeSH
cholinergní látky MeSH
lidé MeSH
proteiny tau metabolismus MeSH
senioři MeSH
zobrazování difuzních tenzorů MeSH
Check Tag
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

BACKGROUND AND OBJECTIVES: Several pathologic processes might contribute to the degeneration of the cholinergic system in aging. We aimed to determine the contribution of amyloid, tau, and cerebrovascular biomarkers toward the degeneration of cholinergic white matter (WM) projections in cognitively unimpaired individuals. METHODS: The contribution of amyloid and tau pathology was assessed through CSF levels of the Aβ42/40 ratio and phosphorylated tau (p-tau). CSF Aβ38 levels were also measured. Cerebrovascular pathology was assessed using automatic segmentations of WM lesions (WMLs) on MRI. Cholinergic WM projections (i.e., cingulum and external capsule pathways) were modeled using tractography based on diffusion tensor imaging data. Sex and APOE ε4 carriership were also included in the analysis as variables of interest. RESULTS: We included 203 cognitively unimpaired individuals from the H70 Gothenburg Birth Cohort Studies (all individuals aged 70 years, 51% female). WM lesion burden was the most important contributor to the degeneration of both cholinergic pathways (increase in mean square error [IncMSE] = 98.8% in the external capsule pathway and IncMSE = 93.3% in the cingulum pathway). Levels of Aβ38 and p-tau also contributed to cholinergic WM degeneration, especially in the external capsule pathway (IncMSE = 28.4% and IncMSE = 23.4%, respectively). The Aβ42/40 ratio did not contribute notably to the models (IncMSE<3.0%). APOE ε4 carriers showed poorer integrity in the cingulum pathway (IncMSE = 21.33%). Women showed poorer integrity of the external capsule pathway (IncMSE = 21.55%), which was independent of amyloid status as reflected by the nonsignificant differences in integrity when comparing amyloid-positive vs amyloid-negative women participants (T201 = -1.55; p = 0.123). DISCUSSION: In cognitively unimpaired older individuals, WMLs play a central role in the degeneration of cholinergic pathways. Our findings highlight the importance of WM lesion burden in the elderly population, which should be considered in the development of prevention programs for neurodegeneration and cognitive impairment.

Clinical Dementia Research Section Department of Psychosomatic Medicine University Medicine Rostock

Clinical Memory Research Unit Department of Clinical Sciences Lund University Malmö

Dementia Research Centre Institute of Neurology University College London

Dementia Research Institute at UCL London UK

Department of Cybernetics Robotics and Cybernetics Czech Technical University Prague Czech Republic

Department of Neurodegenerative Disease UCL Institute of Neurology London

Department of Neuroimaging Centre for Neuroimaging Sciences Institute of Psychiatry Psychology and Neuroscience King's College London UK

Department of Psychiatry Cognition and Old Age Psychiatry Sahlgrenska University Hospital Gothenburg

Department of Psychology Stockholm University Sweden

Department of Radiology Mayo Clinic Rochester MN

From the Division of Clinical Geriatrics Department of Clinical Neuroscience Karolinska Institutet Stockholm

German Center for Neurodegenerative Diseases Rostock Germany

Hong Kong Center for Neurodegenerative Diseases China

Neuropsychiatric Epidemiology Unit at the University of Gothenburg

Theme Inflammation and Aging Karolinska University Hospital Huddinge Sweden

Unidad de Trastornos del Movimiento Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla Spain

Wallenberg Centre for Molecular and Translational Medicine Institute of Physiology and Neuroscience University of Gothenburg Sweden

Citace poskytuje Crossref.org

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100 1_: $a Cedres, Nira $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK $1 https://orcid.org/0000000218506451

245 10: $a Association of Cerebrovascular and Alzheimer Disease Biomarkers With Cholinergic White Matter Degeneration in Cognitively Unimpaired Individuals / $c N. Cedres, D. Ferreira, M. Nemy, A. Machado, JB. Pereira, S. Shams, LO. Wahlund, A. Zettergren, O. Stepankova, L. Vyslouzilova, M. Eriksdotter, S. Teipel, MJ. Grothe, K. Blennow, H. Zetterberg, M. Schöll, S. Kern, I. Skoog, E. Westman

520 9_: $a BACKGROUND AND OBJECTIVES: Several pathologic processes might contribute to the degeneration of the cholinergic system in aging. We aimed to determine the contribution of amyloid, tau, and cerebrovascular biomarkers toward the degeneration of cholinergic white matter (WM) projections in cognitively unimpaired individuals. METHODS: The contribution of amyloid and tau pathology was assessed through CSF levels of the Aβ42/40 ratio and phosphorylated tau (p-tau). CSF Aβ38 levels were also measured. Cerebrovascular pathology was assessed using automatic segmentations of WM lesions (WMLs) on MRI. Cholinergic WM projections (i.e., cingulum and external capsule pathways) were modeled using tractography based on diffusion tensor imaging data. Sex and APOE ε4 carriership were also included in the analysis as variables of interest. RESULTS: We included 203 cognitively unimpaired individuals from the H70 Gothenburg Birth Cohort Studies (all individuals aged 70 years, 51% female). WM lesion burden was the most important contributor to the degeneration of both cholinergic pathways (increase in mean square error [IncMSE] = 98.8% in the external capsule pathway and IncMSE = 93.3% in the cingulum pathway). Levels of Aβ38 and p-tau also contributed to cholinergic WM degeneration, especially in the external capsule pathway (IncMSE = 28.4% and IncMSE = 23.4%, respectively). The Aβ42/40 ratio did not contribute notably to the models (IncMSE<3.0%). APOE ε4 carriers showed poorer integrity in the cingulum pathway (IncMSE = 21.33%). Women showed poorer integrity of the external capsule pathway (IncMSE = 21.55%), which was independent of amyloid status as reflected by the nonsignificant differences in integrity when comparing amyloid-positive vs amyloid-negative women participants (T201 = -1.55; p = 0.123). DISCUSSION: In cognitively unimpaired older individuals, WMLs play a central role in the degeneration of cholinergic pathways. Our findings highlight the importance of WM lesion burden in the elderly population, which should be considered in the development of prevention programs for neurodegeneration and cognitive impairment.

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655 _2: $a časopisecké články $7 D016428

655 _2: $a práce podpořená grantem $7 D013485

700 1_: $a Ferreira, Daniel $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. daniel.ferreira.padilla@ki.se $1 https://orcid.org/0000000195224338

700 1_: $a Nemy, Milan $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Machado, Alejandra $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Pereira, Joana B $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Shams, Sara $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Wahlund, Lars-Olof $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Zettergren, Anna $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Stepankova, Olga $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Vyslouzilova, Lenka $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Eriksdotter, Maria $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Teipel, Stefan $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Grothe, Michel J $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Blennow, Kaj $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK $1 https://orcid.org/0000000218904193

700 1_: $a Zetterberg, Henrik $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK $1 https://orcid.org/0000000246716763

700 1_: $a Schöll, Michael $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK $1 https://orcid.org/0000000178001781

700 1_: $a Kern, Silke $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Skoog, Ingmar $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK

700 1_: $a Westman, Eric $u From the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK $1 https://orcid.org/0000000231152977

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