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Alginate-Based Micro- and Nanosystems for Targeted Cancer Therapy
S. Iravani, RS. Varma
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, přehledy
NLK
Directory of Open Access Journals
od 2003
Free Medical Journals
od 2003
PubMed Central
od 2003
Europe PubMed Central
od 2003
ProQuest Central
od 2003-01-01
Open Access Digital Library
od 2003-01-01
Open Access Digital Library
od 2003-01-01
Health & Medicine (ProQuest)
od 2003-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2003
PubMed
36286422
DOI
10.3390/md20100598
Knihovny.cz E-zdroje
- MeSH
- algináty * MeSH
- biologická dostupnost MeSH
- lékové transportní systémy metody MeSH
- léky s prodlouženým účinkem MeSH
- lidé MeSH
- nádory * farmakoterapie MeSH
- rozpustnost MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Alginates have been widely explored due to their salient advantages of hydrophilicity, biocompatibility, mucoadhesive features, bioavailability, environmentally-benign properties, and cost-effectiveness. They are applied for designing micro- and nanosystems for controlled and targeted drug delivery and cancer therapy as alginate biopolymers find usage in encapsulating anticancer drugs to improve their bioavailability, sustained release, pharmacokinetics, and bio-clearance. Notably, these nanomaterials can be applied for photothermal, photodynamic, and chemodynamic therapy of cancers/tumors. Future explorations ought to be conducted to find novel alginate-based (nano)systems for targeted cancer therapy using advanced drug delivery techniques with benefits of non-invasiveness, patient compliance, and convenience of drug administration. Thus, some critical parameters such as mucosal permeability, stability in the gastrointestinal tract environment, and drug solubility ought to be considered. In addition, the comprehensive clinical translational studies along with the optimization of synthesis techniques still need to be addressed. Herein, we present an overview of the current state of knowledge and recent developments pertaining to the applications of alginate-based micro- and nanosystems for targeted cancer therapy based on controlled drug delivery, photothermal therapy, and chemodynamic/photodynamic therapy approaches, focusing on important challenges and future directions.
Citace poskytuje Crossref.org
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