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Outcome of Cataract Surgery in Patients With Retinitis Pigmentosa
XT. Nguyen, AAHJ. Thiadens, M. Fiocco, W. Tan, M. McKibbin, CCW. Klaver, MA. Meester-Smoor, C. Van Cauwenbergh, I. Strubbe, A. Vergaro, JR. Pott, CB. Hoyng, BP. Leroy, R. Zemaitiene, KN. Khan, CJF. Boon
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- dospělí MeSH
- fakoemulzifikace * MeSH
- implantace nitrooční čočky MeSH
- katarakta * komplikace MeSH
- lidé středního věku MeSH
- lidé MeSH
- retinopathia pigmentosa * komplikace diagnóza chirurgie MeSH
- retrospektivní studie MeSH
- senioři MeSH
- zkalení zadního pouzdra čočky * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, noncomparative clinical study. METHODS: Preoperative, intraoperative, and postoperative data of patients with RP who were undergoing cataract surgery were collected from several expertise centers across Europe. RESULTS: In total, 295 eyes of 226 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (ie, 20/214 to 20/129 Snellen) in the first treated eye (-0.22 logMAR; 95% CI = -0.31 to -0.13; P < .001) and from 0.80 to 0.56 logMAR (ie, 20/126 to 20/73 Snellen) in the second treated eye (-0.24 logMAR; 95% CI = -0.32 to -0.15; P < .001). Marked BCVA improvements (postoperative change in BCVA of ≥0.3 logMAR) were observed in 87 of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%) and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 of 295 eyes (38%). CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor of visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common and may increase the risk of complications.
Center for Medical Genetics Ghent University and Ghent University Hospital Ghent Belgium
Department of Biomedical Data Sciences Leiden University Medical Center Leiden Netherlands
Department of Epidemiology Erasmus University Medical Center Rotterdam Rotterdam Netherlands
Department of Ophthalmology Amsterdam University Medical Centers Amsterdam Netherlands
Department of Ophthalmology Erasmus University Medical Center Rotterdam Netherlands
Department of Ophthalmology Ghent University and Ghent University Hospital Ghent Belgium
Department of Ophthalmology Harvard Medical School Boston Massachusetts USA
Department of Ophthalmology Leeds Teaching Hospitals NHS Trust Leeds United Kingdom
Department of Ophthalmology Lithuanian University of Health Sciences Kaunas Lithuania
Department of Ophthalmology Radboud University Medical Center Nijmegen Netherlands
Division of Ophthalmology The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA
From the Department of Ophthalmology Leiden University Medical Center Leiden Netherlands
Institute of Molecular and Clinical Ophthalmology University of Basel Basel Switzerland
Mathematical Institute Leiden University Leiden the Netherlands
Novartis Institute of BioMedical Research Cambridge Massachusetts USA
Citace poskytuje Crossref.org
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- $a PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, noncomparative clinical study. METHODS: Preoperative, intraoperative, and postoperative data of patients with RP who were undergoing cataract surgery were collected from several expertise centers across Europe. RESULTS: In total, 295 eyes of 226 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (ie, 20/214 to 20/129 Snellen) in the first treated eye (-0.22 logMAR; 95% CI = -0.31 to -0.13; P < .001) and from 0.80 to 0.56 logMAR (ie, 20/126 to 20/73 Snellen) in the second treated eye (-0.24 logMAR; 95% CI = -0.32 to -0.15; P < .001). Marked BCVA improvements (postoperative change in BCVA of ≥0.3 logMAR) were observed in 87 of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%) and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 of 295 eyes (38%). CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor of visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common and may increase the risk of complications.
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