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Radiogenomic markers enable risk stratification and inference of mutational pathway states in head and neck cancer
CP. Spielvogel, S. Stoiber, L. Papp, D. Krajnc, M. Grahovac, E. Gurnhofer, K. Trachtova, V. Bystry, A. Leisser, B. Jank, J. Schnoell, L. Kadletz, G. Heiduschka, T. Beyer, M. Hacker, L. Kenner, AR. Haug
Language English Country Germany
Document type Journal Article, Comment
NLK
ProQuest Central
from 2002 to 1 year ago
Medline Complete (EBSCOhost)
from 2002-01-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 2002 to 1 year ago
Health & Medicine (ProQuest)
from 2002 to 1 year ago
- MeSH
- Squamous Cell Carcinoma of Head and Neck diagnostic imaging genetics MeSH
- Genetic Markers MeSH
- Risk Assessment MeSH
- Humans MeSH
- Head and Neck Neoplasms * diagnostic imaging genetics MeSH
- Prognosis MeSH
- Retrospective Studies MeSH
- Carcinoma, Squamous Cell * pathology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Comment MeSH
PURPOSE: Head and neck squamous cell carcinomas (HNSCCs) are a molecularly, histologically, and clinically heterogeneous set of tumors originating from the mucosal epithelium of the oral cavity, pharynx, and larynx. This heterogeneous nature of HNSCC is one of the main contributing factors to the lack of prognostic markers for personalized treatment. The aim of this study was to develop and identify multi-omics markers capable of improved risk stratification in this highly heterogeneous patient population. METHODS: In this retrospective study, we approached this issue by establishing radiogenomics markers to identify high-risk individuals in a cohort of 127 HNSCC patients. Hybrid in vivo imaging and whole-exome sequencing were employed to identify quantitative imaging markers as well as genetic markers on pathway-level prognostic in HNSCC. We investigated the deductibility of the prognostic genetic markers using anatomical and metabolic imaging using positron emission tomography combined with computed tomography. Moreover, we used statistical and machine learning modeling to investigate whether a multi-omics approach can be used to derive prognostic markers for HNSCC. RESULTS: Radiogenomic analysis revealed a significant influence of genetic pathway alterations on imaging markers. A highly prognostic radiogenomic marker based on cellular senescence was identified. Furthermore, the radiogenomic biomarkers designed in this study vastly outperformed the prognostic value of markers derived from genetics and imaging alone. CONCLUSION: Using the identified markers, a clinically meaningful stratification of patients is possible, guiding the identification of high-risk patients and potentially aiding in the development of effective targeted therapies.
Center for Medical Physics and Biomedical Engineering Medical University of Vienna Vienna Austria
Centre for Molecular Medicine Central European Institute of Technology Brno Czech Republic
Christian Doppler Laboratory for Applied Metabolomics Vienna Austria
Clinical Institute of Pathology Medical University of Vienna Vienna Austria
Department of Otorhinolaryngology Head and Neck Surgery Medical University of Vienna Vienna Austria
References provided by Crossref.org
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