-
Je něco špatně v tomto záznamu ?
Intravenous Thrombolysis in Posterior versus Anterior Circulation Stroke: Clinical Outcome Differs Only in Patients with Large Vessel Occlusion
S. Halúsková, R. Herzig, R. Mikulík, S. Bělašková, M. Reiser, L. Jurák, D. Václavík, M. Bar, L. Klečka, T. Řepík, V. Šigut, A. Tomek, D. Hlinovský, D. Šaňák, O. Vyšata, M. Vališ, . On Behalf Of The Czech Sits Investigators
Status neindexováno Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
Grantová podpora
Cooperatio Program, research area NEUR
Charles University
DRO - UHHK 00179906
Ministry of Health
IRIS-TEPUS Project No. LTC20051 (INTER-EXCELLENCE INTER-COST Program)
Ministry of Education Youth and Sports
No. CA18118 (IRENE COST Action)
COST Association
STROCZECH within CZECRIN Large Research Infrastructure (No. LM2023049)
Czech Republic
NLK
Directory of Open Access Journals
od 2013
PubMed Central
od 2013
Europe PubMed Central
od 2013
ProQuest Central
od 2013-01-01
Open Access Digital Library
od 2013-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2013
- Publikační typ
- časopisecké články MeSH
The safety and efficacy of intravenous thrombolysis (IVT) are well established in anterior circulation stroke (ACS) but are much less clear for posterior circulation stroke (PCS). The aim of this study was to evaluate the occurrence of parenchymal hematoma (PH) and 3-month clinical outcomes after IVT in PCS and ACS. In an observational, cohort multicenter study, we analyzed data from ischemic stroke patients treated with IVT prospectively collected in the SITS (Safe Implementation of Treatments in Stroke) registry in the Czech Republic between 2004 and 2018. Out of 10,211 patients, 1166 (11.4%) had PCS, and 9045 (88.6%) ACS. PH was less frequent in PCS versus ACS patients: 3.6 vs. 5.9%, odds ratio (OR) = 0.594 in the whole set, 4.4 vs. 7.8%, OR = 0.543 in those with large vessel occlusion (LVO), and 2.2 vs. 4.7%, OR = 0.463 in those without LVO. At 3 months, PCS patients compared with ACS patients achieved more frequently excellent clinical outcomes (modified Rankin scale [mRS] 0-1: 55.5 vs. 47.6%, OR = 1.371 in the whole set and 49.2 vs. 37.6%, OR = 1.307 in those with LVO), good clinical outcomes (mRS 0-2: 69.9 vs. 62.8%, OR = 1.377 in the whole set and 64.5 vs. 50.5%, OR = 1.279 in those with LVO), and had lower mortality (12.4 vs. 16.6%, OR = 0.716 in the whole set and 18.4 vs. 25.5%, OR = 0.723 in those with LVO) (p < 0.05 in all cases). In PCS versus ACS patients, an extensive analysis showed a lower risk of PH both in patients with and without LVO, more frequent excellent and good clinical outcomes, and lower mortality 3 months after IVT in patients with LVO.
Neurocenter Regional Hospital Liberec 460 63 Liberec Czech Republic
Research Institute for Biomedical Science 500 02 Hradec Králové Czech Republic
Stroke Center Department of Neurology City Hospital Ostrava 703 00 Ostrava Czech Republic
Stroke Center Department of Neurology Krnov Hospital 794 01 Krnov Czech Republic
Stroke Center Department of Neurology Thomayer University Hospital 140 59 Prague Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24005819
- 003
- CZ-PrNML
- 005
- 20240412131017.0
- 007
- ta
- 008
- 240405s2024 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3390/biomedicines12020404 $2 doi
- 035 __
- $a (PubMed)38398006
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Halúsková, Simona $u Department of Neurology, Faculty of Medicine in Hradec Králové, Charles University, 500 03 Hradec Králové, Czech Republic $u Department of Neurology, Faculty of Health Studies, Pardubice University and Pardubice Hospital, 532 10 Pardubice, Czech Republic
- 245 10
- $a Intravenous Thrombolysis in Posterior versus Anterior Circulation Stroke: Clinical Outcome Differs Only in Patients with Large Vessel Occlusion / $c S. Halúsková, R. Herzig, R. Mikulík, S. Bělašková, M. Reiser, L. Jurák, D. Václavík, M. Bar, L. Klečka, T. Řepík, V. Šigut, A. Tomek, D. Hlinovský, D. Šaňák, O. Vyšata, M. Vališ, . On Behalf Of The Czech Sits Investigators
- 520 9_
- $a The safety and efficacy of intravenous thrombolysis (IVT) are well established in anterior circulation stroke (ACS) but are much less clear for posterior circulation stroke (PCS). The aim of this study was to evaluate the occurrence of parenchymal hematoma (PH) and 3-month clinical outcomes after IVT in PCS and ACS. In an observational, cohort multicenter study, we analyzed data from ischemic stroke patients treated with IVT prospectively collected in the SITS (Safe Implementation of Treatments in Stroke) registry in the Czech Republic between 2004 and 2018. Out of 10,211 patients, 1166 (11.4%) had PCS, and 9045 (88.6%) ACS. PH was less frequent in PCS versus ACS patients: 3.6 vs. 5.9%, odds ratio (OR) = 0.594 in the whole set, 4.4 vs. 7.8%, OR = 0.543 in those with large vessel occlusion (LVO), and 2.2 vs. 4.7%, OR = 0.463 in those without LVO. At 3 months, PCS patients compared with ACS patients achieved more frequently excellent clinical outcomes (modified Rankin scale [mRS] 0-1: 55.5 vs. 47.6%, OR = 1.371 in the whole set and 49.2 vs. 37.6%, OR = 1.307 in those with LVO), good clinical outcomes (mRS 0-2: 69.9 vs. 62.8%, OR = 1.377 in the whole set and 64.5 vs. 50.5%, OR = 1.279 in those with LVO), and had lower mortality (12.4 vs. 16.6%, OR = 0.716 in the whole set and 18.4 vs. 25.5%, OR = 0.723 in those with LVO) (p < 0.05 in all cases). In PCS versus ACS patients, an extensive analysis showed a lower risk of PH both in patients with and without LVO, more frequent excellent and good clinical outcomes, and lower mortality 3 months after IVT in patients with LVO.
- 590 __
- $a NEINDEXOVÁNO
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Herzig, Roman $u Department of Neurology, Faculty of Medicine in Hradec Králové, Charles University, 500 03 Hradec Králové, Czech Republic $u Department of Neurology, Comprehensive Stroke Center, University Hospital Hradec Králové, 500 05 Hradec Králové, Czech Republic $u Research Institute for Biomedical Science, 500 02 Hradec Králové, Czech Republic $1 https://orcid.org/0000000172387724 $7 mzk2007411122
- 700 1_
- $a Mikulík, Robert $u International Clinical Research Center, St. Anne's University Hospital in Brno, 602 00 Brno, Czech Republic
- 700 1_
- $a Bělašková, Silvie $u International Clinical Research Center, St. Anne's University Hospital in Brno, 602 00 Brno, Czech Republic
- 700 1_
- $a Reiser, Martin $u Department of Neurology, Comprehensive Stroke Center, Hospital České Budějovice, 370 01 České Budějovice, Czech Republic
- 700 1_
- $a Jurák, Lubomír $u Neurocenter, Regional Hospital Liberec, 460 63 Liberec, Czech Republic $1 https://orcid.org/0000000220962798 $7 xx0267976
- 700 1_
- $a Václavík, Daniel $u Department of Neurology, Faculty of Medicine in Hradec Králové, Charles University, 500 03 Hradec Králové, Czech Republic $u Department of Neurology, Comprehensive Stroke Center, University Hospital Hradec Králové, 500 05 Hradec Králové, Czech Republic $u Department of Clinical Neurosciences, Faculty of Medicine, University of Ostrava, 708 00 Ostrava, Czech Republic $u Research and Training Institute Agel, Stroke Center, Department of Neurology, Hospital Ostrava Vítkovice, 703 00 Ostrava, Czech Republic
- 700 1_
- $a Bar, Michal $u Department of Neurology, Comprehensive Stroke Center, Faculty of Medicine, University of Ostrava and University Hospital Ostrava, 708 52 Ostrava, Czech Republic $1 https://orcid.org/0000000250495844 $7 xx0047124
- 700 1_
- $a Klečka, Lukáš $u Stroke Center, Department of Neurology, City Hospital Ostrava, 703 00 Ostrava, Czech Republic $1 https://orcid.org/0000000213165782
- 700 1_
- $a Řepík, Tomáš $u Department of Neurology, Comprehensive Stroke Center, University Hospital in Pilsen and Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic
- 700 1_
- $a Šigut, Vladimír $u Stroke Center, Department of Neurology, Krnov Hospital, 794 01 Krnov, Czech Republic
- 700 1_
- $a Tomek, Aleš $u Department of Neurology, Comprehensive Stroke Center, Charles University 2nd Faculty of Medicine, Motol University Hospital, 150 06 Prague, Czech Republic
- 700 1_
- $a Hlinovský, David $u Stroke Center, Department of Neurology, Thomayer University Hospital, 140 59 Prague, Czech Republic $1 https://orcid.org/0009000667198674
- 700 1_
- $a Šaňák, Daniel $u Department of Neurology, Comprehensive Stroke Center, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, 779 00 Olomouc, Czech Republic
- 700 1_
- $a Vyšata, Oldřich $u Department of Neurology, Faculty of Medicine in Hradec Králové, Charles University, 500 03 Hradec Králové, Czech Republic $u Department of Neurology, Comprehensive Stroke Center, University Hospital Hradec Králové, 500 05 Hradec Králové, Czech Republic
- 700 1_
- $a Vališ, Martin $u Research Institute for Biomedical Science, 500 02 Hradec Králové, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital in Brno, 602 00 Brno, Czech Republic
- 700 1_
- $a On Behalf Of The Czech Sits Investigators,
- 773 0_
- $w MED00205373 $t Biomedicines $x 2227-9059 $g Roč. 12, č. 2 (2024)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38398006 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20240405 $b ABA008
- 991 __
- $a 20240412131009 $b ABA008
- 999 __
- $a ok $b bmc $g 2076038 $s 1215581
- BAS __
- $a 3
- BAS __
- $a PreBMC-PubMed-not-MEDLINE
- BMC __
- $a 2024 $b 12 $c 2 $e 20240209 $i 2227-9059 $m Biomedicines $n Biomedicines $x MED00205373
- GRA __
- $a Cooperatio Program, research area NEUR $p Charles University
- GRA __
- $a DRO - UHHK 00179906 $p Ministry of Health
- GRA __
- $a IRIS-TEPUS Project No. LTC20051 (INTER-EXCELLENCE INTER-COST Program) $p Ministry of Education Youth and Sports
- GRA __
- $a No. CA18118 (IRENE COST Action) $p COST Association
- GRA __
- $a STROCZECH within CZECRIN Large Research Infrastructure (No. LM2023049) $p Czech Republic
- LZP __
- $a Pubmed-20240405
