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Autor
Bar, Michal 1 Bělašková, Silvie 1 Halúsková, Simona 1 Herzig, Roman 1 Hlinovský, David 1 Jurák, Lubomír 1 Klečka, Lukáš 1 Mikulík, Robert 1 On Behalf Of The Czech Sits Investiga... 1 Reiser, Martin 1 Tomek, Aleš 1 Vališ, Martin 1 Vyšata, Oldřich 1 Václavík, Daniel 1 Řepík, Tomáš 1 Šaňák, Daniel 1 Šigut, Vladimír 1
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Pracoviště
Department of Clinical Neurosciences ... 1 Department of Neurology Comprehensive... 1 Department of Neurology Comprehensive... 1 Department of Neurology Comprehensive... 1 Department of Neurology Comprehensive... 1 Department of Neurology Comprehensive... 1 Department of Neurology Comprehensive... 1 Department of Neurology Faculty of He... 1 Department of Neurology Faculty of Me... 1 International Clinical Research Cente... 1 Neurocenter Regional Hospital Liberec... 1 Research Institute for Biomedical Sci... 1 Research and Training Institute Agel ... 1 Stroke Center Department of Neurology... 1 Stroke Center Department of Neurology... 1 Stroke Center Department of Neurology... 1
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Autor
Bar, Michal 1 Bělašková, Silvie 1 Halúsková, Simona 1 Herzig, Roman 1 Hlinovský, David 1 Jurák, Lubomír 1 Klečka, Lukáš 1 Mikulík, Robert 1 On Behalf Of The Czech Sits Investiga... 1 Reiser, Martin 1 Tomek, Aleš 1 Vališ, Martin 1 Vyšata, Oldřich 1 Václavík, Daniel 1 Řepík, Tomáš 1 Šaňák, Daniel 1 Šigut, Vladimír 1
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Pracoviště
Department of Clinical Neurosciences ... 1 Department of Neurology Comprehensive... 1 Department of Neurology Comprehensive... 1 Department of Neurology Comprehensive... 1 Department of Neurology Comprehensive... 1 Department of Neurology Comprehensive... 1 Department of Neurology Comprehensive... 1 Department of Neurology Faculty of He... 1 Department of Neurology Faculty of Me... 1 International Clinical Research Cente... 1 Neurocenter Regional Hospital Liberec... 1 Research Institute for Biomedical Sci... 1 Research and Training Institute Agel ... 1 Stroke Center Department of Neurology... 1 Stroke Center Department of Neurology... 1 Stroke Center Department of Neurology... 1
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- Halúsková, Simona
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Herzig, Roman
Autor Autorita ORCID Department of Neurology, Faculty of Medicine in Hradec Králové, Charles University, 500 03 Hradec Králové, Czech Republic Department of Neurology, Comprehensive Stroke Center, University Hospital Hradec Králové, 500 05 Hradec Králové, Czech Republic Research Institute for Biomedical Science, 500 02 Hradec Králové, Czech Republic
- Mikulík, Robert
- Bělašková, Silvie
- Reiser, Martin
- Jurák, Lubomír
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Václavík, Daniel
Autor Václavík, Daniel Department of Neurology, Faculty of Medicine in Hradec Králové, Charles University, 500 03 Hradec Králové, Czech Republic Department of Neurology, Comprehensive Stroke Center, University Hospital Hradec Králové, 500 05 Hradec Králové, Czech Republic Department of Clinical Neurosciences, Faculty of Medicine, University of Ostrava, 708 00 Ostrava, Czech Republic Research and Training Institute Agel, Stroke Center, Department of Neurology, Hospital Ostrava Vítkovice, 703 00 Ostrava, Czech Republic
- Bar, Michal
- Klečka, Lukáš
- Řepík, Tomáš
PubMed Central od 2013
Europe PubMed Central od 2013
ProQuest Central od 2013-01-01
Open Access Digital Library od 2013-01-01
ROAD: Directory of Open Access Scholarly Resources od 2013
PubMed
38398006
DOI
10.3390/biomedicines12020404
Knihovny.cz E-zdroje
The safety and efficacy of intravenous thrombolysis (IVT) are well established in anterior circulation stroke (ACS) but are much less clear for posterior circulation stroke (PCS). The aim of this study was to evaluate the occurrence of parenchymal hematoma (PH) and 3-month clinical outcomes after IVT in PCS and ACS. In an observational, cohort multicenter study, we analyzed data from ischemic stroke patients treated with IVT prospectively collected in the SITS (Safe Implementation of Treatments in Stroke) registry in the Czech Republic between 2004 and 2018. Out of 10,211 patients, 1166 (11.4%) had PCS, and 9045 (88.6%) ACS. PH was less frequent in PCS versus ACS patients: 3.6 vs. 5.9%, odds ratio (OR) = 0.594 in the whole set, 4.4 vs. 7.8%, OR = 0.543 in those with large vessel occlusion (LVO), and 2.2 vs. 4.7%, OR = 0.463 in those without LVO. At 3 months, PCS patients compared with ACS patients achieved more frequently excellent clinical outcomes (modified Rankin scale [mRS] 0-1: 55.5 vs. 47.6%, OR = 1.371 in the whole set and 49.2 vs. 37.6%, OR = 1.307 in those with LVO), good clinical outcomes (mRS 0-2: 69.9 vs. 62.8%, OR = 1.377 in the whole set and 64.5 vs. 50.5%, OR = 1.279 in those with LVO), and had lower mortality (12.4 vs. 16.6%, OR = 0.716 in the whole set and 18.4 vs. 25.5%, OR = 0.723 in those with LVO) (p < 0.05 in all cases). In PCS versus ACS patients, an extensive analysis showed a lower risk of PH both in patients with and without LVO, more frequent excellent and good clinical outcomes, and lower mortality 3 months after IVT in patients with LVO.
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