Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Age-Related Differences in the Presentation, Management, and Clinical Outcomes of 100,000 Patients With Venous Thromboembolism in the RIETE Registry

AG. Ortega, D. Jiménez, A. Pedro-Tudela, C. Pérez-Ductor, C. Fernández-Capitán, C. Falgá, A. Skride, C. Siniscalchi, I. Weinberg, M. Monreal, RIETE investigators

. 2024 ; 60 (3) : 143-152. [pub] 20240103

Language xxx, English Country Spain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc24006916

INTRODUCTION: Although older adults represent a significant proportion of patients with venous thromboembolism (VTE), the data on the impact of age-related differences in the clinical presentation, management, and outcomes of VTE are scarce. METHODS: We analyzed data from the RIETE registry database, an ongoing global observational registry of patients with objectively confirmed VTE, to compare patient characteristics, clinical presentation, treatments, and outcomes between elderly (≥70 years) vs. non-elderly (<70 years) patients. RESULTS: From January 2001 to March 2021, 100,000 adult patients were enrolled in RIETE. Elderly patients (47.9%) were more frequently women (58.2% vs. 43.5%), more likely had unprovoked VTE (50.5% vs. 45.1%) and most often presented with severe renal failure (10.2% vs. 1.2%) and acute pulmonary embolism (PE) (vs. deep vein thrombosis) (54.3% vs. 44.5%) compared to non-elderly patients (p<0.001 for all comparisons). For the PE subgroup, elderly patients more frequently had non-low risk PE (78.9% vs. 50.7%; p<0.001), respiratory failure (33.9% vs. 21.8%; p<0.001) and myocardial injury (40.0% vs. 26.2%; p<0.001) compared to non-elderly patients. Thrombolysis (0.9% vs. 1.7%; p<0.001) and direct oral anticoagulants (8.8% vs. 11.8%; p<0.001) were less frequently administered to elderly patients. Elderly patients showed a significantly higher 30-day all-cause mortality (adjusted odds ratio [OR] 1.36, 95%CI: 1.22-1.52) and major bleeding (OR, 2.08; 95%CI, 1.85-2.33), but a lower risk of 30-day VTE recurrences (OR, 0.62, 95%CI, 0.54-0.71). CONCLUSIONS: Compared with non-elderly patients, elderly patients had a different VTE clinical profile. Advanced therapies were less frequently used in older patients. Age was an independent predictor of mortality.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24006916
003      
CZ-PrNML
005      
20240423155555.0
007      
ta
008      
240412s2024 sp f 000 0|eng s
009      
AR
024    7_
$a 10.1016/j.arbres.2023.12.016 $2 doi
035    __
$a (PubMed)38220587
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng spa
044    __
$a sp
100    1_
$a Ortega, Alberto García $u Respiratory Department, Hospital Dr. Peset, Valencia, Spain; Medical Research Institute Hospital La Fe (IISLAFE), Valencia, Spain. Electronic address: albortgva@gmail.com
245    10
$a Age-Related Differences in the Presentation, Management, and Clinical Outcomes of 100,000 Patients With Venous Thromboembolism in the RIETE Registry / $c AG. Ortega, D. Jiménez, A. Pedro-Tudela, C. Pérez-Ductor, C. Fernández-Capitán, C. Falgá, A. Skride, C. Siniscalchi, I. Weinberg, M. Monreal, RIETE investigators
520    9_
$a INTRODUCTION: Although older adults represent a significant proportion of patients with venous thromboembolism (VTE), the data on the impact of age-related differences in the clinical presentation, management, and outcomes of VTE are scarce. METHODS: We analyzed data from the RIETE registry database, an ongoing global observational registry of patients with objectively confirmed VTE, to compare patient characteristics, clinical presentation, treatments, and outcomes between elderly (≥70 years) vs. non-elderly (<70 years) patients. RESULTS: From January 2001 to March 2021, 100,000 adult patients were enrolled in RIETE. Elderly patients (47.9%) were more frequently women (58.2% vs. 43.5%), more likely had unprovoked VTE (50.5% vs. 45.1%) and most often presented with severe renal failure (10.2% vs. 1.2%) and acute pulmonary embolism (PE) (vs. deep vein thrombosis) (54.3% vs. 44.5%) compared to non-elderly patients (p<0.001 for all comparisons). For the PE subgroup, elderly patients more frequently had non-low risk PE (78.9% vs. 50.7%; p<0.001), respiratory failure (33.9% vs. 21.8%; p<0.001) and myocardial injury (40.0% vs. 26.2%; p<0.001) compared to non-elderly patients. Thrombolysis (0.9% vs. 1.7%; p<0.001) and direct oral anticoagulants (8.8% vs. 11.8%; p<0.001) were less frequently administered to elderly patients. Elderly patients showed a significantly higher 30-day all-cause mortality (adjusted odds ratio [OR] 1.36, 95%CI: 1.22-1.52) and major bleeding (OR, 2.08; 95%CI, 1.85-2.33), but a lower risk of 30-day VTE recurrences (OR, 0.62, 95%CI, 0.54-0.71). CONCLUSIONS: Compared with non-elderly patients, elderly patients had a different VTE clinical profile. Advanced therapies were less frequently used in older patients. Age was an independent predictor of mortality.
650    _2
$a lidé $7 D006801
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a senioři $7 D000368
650    _2
$a lidé středního věku $7 D008875
650    12
$a žilní tromboembolie $x farmakoterapie $x epidemiologie $7 D054556
650    12
$a plicní embolie $x farmakoterapie $x epidemiologie $7 D011655
650    _2
$a krvácení $x epidemiologie $x etiologie $7 D006470
650    _2
$a registrace $7 D012042
650    _2
$a antikoagulancia $x terapeutické užití $7 D000925
650    _2
$a recidiva $7 D012008
655    _2
$a časopisecké články $7 D016428
700    1_
$a Jiménez, David $u Respiratory Department, Hospital Ramón y Cajal, Universidad de Alcalá (IRYCIS), Madrid, Spain; CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain; Medicine Department, Universidad de Alcalá, Madrid, Spain
700    1_
$a Pedro-Tudela, Ana $u Respiratory Department, Hospital Dr. Peset, Valencia, Spain
700    1_
$a Pérez-Ductor, Cristina $u Emergency Department, Hospital Dr. Peset, Valencia, Spain
700    1_
$a Fernández-Capitán, Carmen $u Department of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain
700    1_
$a Falgá, Conxita $u Department of Internal Medicine, Hospital de Mataró, Barcelona, Spain
700    1_
$a Skride, Andris $u Department of Cardiology, Ospedale Pauls Stradins Clinical University Hospital, Riga Stradiņš University, Riga, Latvia
700    1_
$a Siniscalchi, Carmine $u Department of Angiology, Azienda Ospedaliera Universitaria, Parma, Italy
700    1_
$a Weinberg, Ido $u Department of Cardiology, Massachusetts General Hospital, Boston, MA, USA
700    1_
$a Monreal, Manuel $u CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain; Chair for the Study of Thromboembolic Disease, Faculty of Health Sciences, UCAM - Universidad Católica San Antonio de Murcia, Spain
710    2_
$a RIETE investigators
773    0_
$w MED00166557 $t Archivos de bronconeumología $x 1579-2129 $g Roč. 60, č. 3 (2024), s. 143-152
856    41
$u https://pubmed.ncbi.nlm.nih.gov/38220587 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240412 $b ABA008
991    __
$a 20240423155552 $b ABA008
999    __
$a ok $b bmc $g 2081097 $s 1216683
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 60 $c 3 $d 143-152 $e 20240103 $i 1579-2129 $m Archivos de bronconeumología $n Arch. bronconeumol. $x MED00166557
LZP    __
$a Pubmed-20240412

Find record

Citation metrics

Archiving options