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Degeneration of the cholinergic system in individuals with subjective cognitive decline: A systematic review
MA. Rodriguez-Hernandez, I. Alemany, JK. Olofsson, P. Diaz-Galvan, M. Nemy, E. Westman, J. Barroso, D. Ferreira, N. Cedres
Language English Country United States
Document type Systematic Review, Journal Article, Review
- MeSH
- Alzheimer Disease * MeSH
- Biomarkers MeSH
- Cholinergic Agents MeSH
- Cognitive Dysfunction * diagnostic imaging MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Neuroimaging methods MeSH
- Basal Forebrain * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Systematic Review MeSH
BACKGROUND: Subjective cognitive decline (SCD) is a risk factor for future cognitive impairment and dementia. It is uncertain whether the neurodegeneration of the cholinergic system is already present in SCD individuals. We aimed to review the current evidence about the association between SCD and biomarkers of degeneration in the cholinergic system. METHOD: Original articles were extracted from three databases: Pubmed, Web of Sciences, and Scopus, in January 2023. Two researchers screened the studies independently. RESULTS: A total of 11 research articles were selected. SCD was mostly based on amnestic cognitive complaints. Cholinergic system biomarkers included neuroimaging markers of basal forebrain volume, functional connectivity, transcranial magnetic stimulation, or biofluid. The evidence showed associations between basal forebrain atrophy, poorer connectivity of the cholinergic system, and SCD CONCLUSIONS: Degenerative changes in the cholinergic system can be present in SCD. Subjective complaints may help when identifying individuals with brain changes that are associated with cognitive impairment. These findings may have important implications in targeting individuals that may benefit from cholinergic-target treatments at very early stages of neurodegenerative diseases.
Center for Alzheimer Research Stockholm Sweden
Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden
Department of Radiology Mayo Clinic Rochester MN USA
Division of Clinical Geriatrics Care Sciences and Society Karolinska Institutet Stockholm Sweden
References provided by Crossref.org
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- $a BACKGROUND: Subjective cognitive decline (SCD) is a risk factor for future cognitive impairment and dementia. It is uncertain whether the neurodegeneration of the cholinergic system is already present in SCD individuals. We aimed to review the current evidence about the association between SCD and biomarkers of degeneration in the cholinergic system. METHOD: Original articles were extracted from three databases: Pubmed, Web of Sciences, and Scopus, in January 2023. Two researchers screened the studies independently. RESULTS: A total of 11 research articles were selected. SCD was mostly based on amnestic cognitive complaints. Cholinergic system biomarkers included neuroimaging markers of basal forebrain volume, functional connectivity, transcranial magnetic stimulation, or biofluid. The evidence showed associations between basal forebrain atrophy, poorer connectivity of the cholinergic system, and SCD CONCLUSIONS: Degenerative changes in the cholinergic system can be present in SCD. Subjective complaints may help when identifying individuals with brain changes that are associated with cognitive impairment. These findings may have important implications in targeting individuals that may benefit from cholinergic-target treatments at very early stages of neurodegenerative diseases.
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- $a Alemany, Iris $u Department of Psychology, Faculty of Health Sciences, University Fernando Pessoa-Canarias, Santa María de Guia, Spain
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- $a Nemy, Milan $u Department of Cybernetics, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic; Department of Biomedical Engineering and Assistive Technology, Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University in Prague, Prague, Czech Republic; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Center for Alzheimer Research, Stockholm, Sweden; Division of Clinical Geriatrics, Care Sciences and Society. Karolinska Institutet, Stockholm, Sweden
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- $a Westman, Eric $u Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Center for Alzheimer Research, Stockholm, Sweden; Division of Clinical Geriatrics, Care Sciences and Society. Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
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- $a Cedres, Nira $u Department of Psychology, Faculty of Health Sciences, University Fernando Pessoa-Canarias, Santa María de Guia, Spain; Department of Psychology, Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Stockholm, Sweden; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Center for Alzheimer Research, Stockholm, Sweden; Division of Clinical Geriatrics, Care Sciences and Society. Karolinska Institutet, Stockholm, Sweden. Electronic address: ncedres@ufpcanarias.es
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