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CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population

JA. Hubáček, T. Philipp, O. Májek, D. Dlouhá, V. Adámková, L. Dušek

. 2023 ; 69 (5-6) : 181-185. [pub] -

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc24008637

Grant support
IN 00023001 Ministerstvo Zdravotnictví Ceské Republiky

A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (C→T; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case-control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2-positive individuals (P = 0.48; OR; 95 % CI - 0.92; 0.73-1.16). No significant differences in the distribution of genotypes were found when considering co-dominant and recessive genetic models or various between-group comparisons. The CD14 polymorphism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.

References provided by Crossref.org

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