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Management of patients with hypertension and chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. On behalf of the European Society of Hypertension Working Group on Hypertension and the Kidney

JM. Halimi, P. Sarafidis, M. Azizi, G. Bilo, T. Burkard, M. Bursztyn, M. Camafort, N. Chapman, S. Cottone, T. de Backer, J. Deinum, P. Delmotte, M. Dorobantu, M. Doumas, R. Dusing, B. Duly-Bouhanick, JP. Fauvel, P. Fesler, Z. Gaciong, E....

. 2024 ; 33 (1) : 2368800. [pub] 20240623

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, multicentrická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc24013276

Objective Real-life management of patients with hypertension and chronic kidney disease (CKD) among European Society of Hypertension Excellence Centres (ESH-ECs) is unclear : we aimed to investigate it. Methods A survey was conducted in 2023. The questionnaire contained 64 questions asking ESH-ECs representatives to estimate how patients with CKD are managed. Results Overall, 88 ESH-ECS representatives from 27 countries participated. According to the responders, renin-angiotensin system (RAS) blockers, calcium-channel blockers and thiazides were often added when these medications were lacking in CKD patients, but physicians were more prone to initiate RAS blockers (90% [interquartile range: 70-95%]) than MRA (20% [10-30%]), SGLT2i (30% [20-50%]) or (GLP1-RA (10% [5-15%]). Despite treatment optimisation, 30% of responders indicated that hypertension remained uncontrolled (30% (15-40%) vs 18% [10%-25%]) in CKD and CKD patients, respectively). Hyperkalemia was the most frequent barrier to initiate RAS blockers, and dosage reduction was considered in 45% of responders when kalaemia was 5.5-5.9 mmol/L. Conclusions RAS blockers are initiated in most ESH-ECS in CKD patients, but MRA and SGLT2i initiations are less frequent. Hyperkalemia was the main barrier for initiation or adequate dosing of RAS blockade, and RAS blockers' dosage reduction was the usual management.

1st Department of Cardiology National and Kapodistrian University of Athens Hippocratio Hospital Greece

1st Department of Internal Medicine Cardiology Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc Czech Republic

2nd Department of Cardiology Medical School University of Athens ATTIKON Hospital Athens Greece

2nd Department of Internal Medicine St Anne's University Hospital Brno Czech Republic

2nd Prop Department of Internal Medicine Aristotle University Thessaloniki Greece

3rd Department of Internal Medicine Papageorgiou Hospital Aristotle University of Thessaloniki Greece

3rd Internal Department Centre for Hypertension General Faculty Hospital Charles University Prague Czech Republic

AP HP Unité d'hypertension artérielle service de médecine interne Hôpital Avicenne Bobigny France

APHP Service d'Hypertension Artérielle Hôpital Européen Georges Pompidou Paris France

Badajoz Spain

Cardiology Department Klinikum Wels Grieskirchen Wels Austria

Cardiovascular Risk and Hypertension Madrid Spain

Cardiovascular Risk Clinic Western General Hospital Edinburgh UK

Center of Preventive Cardiology Armenia Parounak Zelveian Hospital N2 CJSC Yerevan Armenia

Centre of Cardiology North Estonia Medical Centre Tallinn University of Technology Tallinn Estonia

Centro Studi Diagnosi e Cura dell'Ipertensione Arteriosa e del Rischio Cardiovascolare University of Brescia and ASST Spedali Civili Italy

Clinica Medica University Milano Bicocca Milan Italy

Departement of Nephrology and Hypertension Universitair Ziekenhuis Brussel Department of Nephrology and Hypertension VUB Belgium

Department of Advanced Medical Sciences Federico 2 University of Naples Italy

Department of Cardiology Abdali Hospital Amman Jordan

Department of Cardiology Danderyd University Hospital Corp Stockholm Sweden

Department of Cardiology LAIKO General Hospital Athens Greece

Department of Cardiology Medical University of Graz Graz Austria

Department of Cardiovascular Diseases Division of Cardiology Cliniques Universitaires Saint Luc and Pole of Cardiovascular Research Institut de Recherche Expérimentale et Clinique Université Catholique de Louvain Brussels Belgium

Department of Cardiovascular Diseases Internal Medicine University Hospital Ghent Ghent Belgium

Department of Clinical Sciences Division of Cardiovascular Medicine Karolinska Institute Stockholm Sweden

Department of Clinical Sciences Lund University Skane University Hospital Malmö Sweden

Department of Heart Disease Haukeland University Hospital Bergen Norway

Department of Internal Medicine 4 Medical University Innsbruck Anichstrasse Innsbruck Austria

Department of Internal Medicine and Cardiology University Hospital Ostrava Czech Republic

Department of Internal Medicine Hypertension and Vascular Diseases Medical University of Warsaw Warsaw Poland

Department of Internal Medicine Montpellier University Hospital Montpellier France

Department of Internal Medicine Nephrology Heinrich Heine University Duesseldorf Duesseldorf Germany

Department of Internal Medicine Section of Nephrology Amsterdam University Medical Center Amsterdam Cardiovascular Sciences University of Amsterdam Amsterdam the Netherlands

Department of Medical Sciences University of Turin Italy

Department of Medicine and Surgery University of Milano Bicocca Milan Italy

Department of Medicine and Surgery University of Perugia Unit of Internal Medicine Santa Maria Terni Hospital Terni Italy

Department of Medicine CINTESIS RISE Faculty of Medicine of Porto Portugal

Department of Medicine Radboud University Medical Center Nijmegen the Netherlands

Department of Nephrology and Hypertension Hôpital Ed Herriot Lyon France

Department of Nephrology Cantonal Hospital Graubuenden Chur Switzerland

Department of Nephrology Helsinki University Hospital and University of Helsinki Helsinki Finland

Department of Nephrology Hypertension University Hospital Erlangen Friedrich Alexander University Erlangen Nürnberg Germany

Dept of Nephrology and Hypertension Hypertension Center Hannover Medical School Hannover Germany

Division of Cardiology Izmir Medicana International Hospital Yenisehir Turkey

Division of Medicine Turku University Hospital Turku University Turku Finland

Division of Nephrology University of Liège Hospital Cardiovascular Sciences University of Liège Liège Belgium

Emergency Clinical Hospital of Bucharest Department of Emergency Medicineap Department of Cardiology Bucharest Romania

ESH Excellent Center Hypertension LAIKO University Hospital Athens Greece

Faculty of Medicine School of Medicine Hadassah Hebrew University Jerusalem Israel

Faculty of Medicine University of Ostrava Czech Republic

Fakulty of Medicine Masaryk University Brno Czech Republic

Grande Ospedale Metropolitano UOC di Nefrologia abilitata al trapianto renale CNR Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell'Ipertensione Arteriosa Reggio Calabria Italy

Grzegorz Bilo Department of Cardiology Istituto Auxologico Italiano IRCCS Milan Italy

Hypertension and Vascular Risk Unit Department of Nephrology Hospital del Mar IMIM Universitat Pompeu Fabra Barcelona Spain

Hypertension Clinic Hadassah Hebrew University Medical Center Mount Scopus Jerusalem

Hypertension Outpatient Clinic Cardiology Department Heraklion University General Hospital Heraklion Greece

Hypertension Unit Department of Cardiology HELORA University Hospitals Mons Belgium

Hypertension Unit Department of Internal Medicine Hospital Clinic University of Barcelona Spain

Hypertension Unit Dept of Internal Medicine University Hospital of Heraklion Heraklion Greece

Hypertension Unit KAT General Hospital of Attica Greece

Hypertension Unit of the 1st Department of Medicine Aristotle University of Thessaloniki AHEPA Hospital Thessaloniki Greece

Hypertoniezentrum Bonn Schwerpunktpraxis Kardiologie Angiologie Prävention Rehabilitation Bonn Germany

INSERM UMR 942 MASCOT Paris 13 Université Paris Nord FCRIN INI CRCT Bobigny France

Institute of Clinical Pharmacology and Toxicology Charité Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin Berlin Germany

Internal Medicine Department Hospital Centre of Vila Nova de Gaia Espinho Portugal

Internal Medicine Unit Department of Medicine ESH Excellence Center Unit Italy

Medical Outpatient Department and Hypertension Clinic University Hospital Basel Basel Switzerland

Medinische Klinik für Nephrologie und internistische Intensivtherapie Charité Universitätsmedizin Berlin Berlin Germany

Metropolitan Hospital Piraeus Greece

Peart Rose Clinic Hammersmith Hospital Imperial College Healthcare Trust London UK

PhyMedExp INSERM U1046 CNRS UMR 9214 University of Montpellier Montpellier France

Plava Medical Group Sarajevo Bosnia and Herzegovina

PROMISE Department Nephrology and Dialisys Unit with Hypertension ESH Excellence Centre University Hospital P Giaccone Palermo Italy

School of Medicine 3rd Department of Medicine Sotiria Hospital Hypertension Center STRIDE 7 National and Kapodistrian University of Athens Athens Greece

School of Medicine Aristotle University of Thessaloniki Greece

Service d'HTA et Therapeutique CHU Rangueil Toulouse University Toulouse France

Service de Médecine Interne Hôpital Franco Britannique Levallois Perret France

Service de Médecine Vasculaire et Hypertension Artérielle Centre de compétence régional des maladies artérielles rares Centre d'excellence Européen en Hypertension Artérielle 264 rue Saint Pierre CHU Timone Marseille France

Service de Néphrologie CIC CRB 1404 INSERM EnVi U1096 CHU Rouen France

Service de néphrologie et d'hypertension Lausanne University Hospital and University of Lausanne Lausanne Switzerland

Service de Néphrologie Hypertension Dialyses Transplantation rénale Hôpital Bretonneau Tours France

Service de Néphrologie transplantation dialyse aphérèses CHU Bordeaux France

South Buda Center Hospital St Imre University Teaching Hospital Budapest Hungary

St George University Medical Center Achrafieh Beirut Lebanon

St Josefs Hospital Cloppenburg Germany

UF Hypertension et Athérothrombose Centre Européen d'Excellence en Hypertension Artérielle Service de Cardiologie CHU Michallon Grenoble France

Università degli Studi e IRCCS Ospedale Policlinico San Martino di Genova Italy

Università Politecnica delle Marche and IRCCS INRCA Department of Clinical and Molecular Sciences Ancona Italy

Université Paris Cité Department of Cardiology Paris France

University Hospital of North Norway Department of Nephrology cb Department of Internal Medicine and Cardiology Tromsø Norway

University Hospital Zurich University Heart Center Cardiology and University of Zurich Zurich Switzerland

University of Palermo Department of Nephrology Palermo Italy

Vascular Risk Unit Internal Medicine Virgen de las Nieves University Hospital Granada Spain

Citace poskytuje Crossref.org

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$a Halimi, Jean-Michel $u Service de Néphrologie-Hypertension, Dialyses, Transplantation rénale, Hôpital Bretonneau, Tours, France
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$a Management of patients with hypertension and chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. On behalf of the European Society of Hypertension Working Group on Hypertension and the Kidney / $c JM. Halimi, P. Sarafidis, M. Azizi, G. Bilo, T. Burkard, M. Bursztyn, M. Camafort, N. Chapman, S. Cottone, T. de Backer, J. Deinum, P. Delmotte, M. Dorobantu, M. Doumas, R. Dusing, B. Duly-Bouhanick, JP. Fauvel, P. Fesler, Z. Gaciong, E. Gkaliagkousi, D. Gordin, G. Grassi, C. Grassos, D. Guerrot, J. Huart, R. Izzo, F. Jaén Águila, Z. Járai, T. Kahan, I. Kantola, E. Kociánová, F. Limbourg, M. Lopez-Sublet, F. Mallamaci, A. Manolis, M. Marketou, G. Mayer, A. Mazza, I. MacIntyre, JJ. Mourad, ML. Muiesan, E. Nasr, P. Nilsson, A. Oliveras, O. Ormezzano, V. Paixão-Dias, I. Papadakis, D. Papadopoulos, S. Perl, J. Polónia, R. Pontremoli, G. Pucci, NR. Robles, S. Rubin, LM. Ruilope, LC. Rump, S. Saeed, E. Sanidas, R. Sarzani, R. Schmieder, F. Silhol, S. Sokolovic, M. Solbu, M. Soucek, G. Stergiou, I. Sudano, R. Tabbalat, I. Tengiz, H. Triantafyllidi, K. Tsioufis, J. Václavík, M. van der Giet, PV. der Niepen, F. Veglio, R. Venzin, M. Viigimaa, T. Weber, J. Widimsky, G. Wuerzner, P. Zelveian, P. Zebekakis, S. Lueders, A. Persu, R. Kreutz, L. Vogt
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$a Objective Real-life management of patients with hypertension and chronic kidney disease (CKD) among European Society of Hypertension Excellence Centres (ESH-ECs) is unclear : we aimed to investigate it. Methods A survey was conducted in 2023. The questionnaire contained 64 questions asking ESH-ECs representatives to estimate how patients with CKD are managed. Results Overall, 88 ESH-ECS representatives from 27 countries participated. According to the responders, renin-angiotensin system (RAS) blockers, calcium-channel blockers and thiazides were often added when these medications were lacking in CKD patients, but physicians were more prone to initiate RAS blockers (90% [interquartile range: 70-95%]) than MRA (20% [10-30%]), SGLT2i (30% [20-50%]) or (GLP1-RA (10% [5-15%]). Despite treatment optimisation, 30% of responders indicated that hypertension remained uncontrolled (30% (15-40%) vs 18% [10%-25%]) in CKD and CKD patients, respectively). Hyperkalemia was the most frequent barrier to initiate RAS blockers, and dosage reduction was considered in 45% of responders when kalaemia was 5.5-5.9 mmol/L. Conclusions RAS blockers are initiated in most ESH-ECS in CKD patients, but MRA and SGLT2i initiations are less frequent. Hyperkalemia was the main barrier for initiation or adequate dosing of RAS blockade, and RAS blockers' dosage reduction was the usual management.
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$a Gaciong, Zbigniew $u Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, Poland
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$a Izzo, Raffaele $u Department of Advanced Medical Sciences, Federico II University of Naples, Italy $1 https://orcid.org/0000000203082836
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$a Jaén Águila, Fernando $u Vascular Risk Unit, Internal Medicine, Virgen de las Nieves University Hospital, Granada, Spain
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$a Kantola, Ilkka $u Division of Medicine, Turku University Hospital, Turku University, Turku, Finland $1 https://orcid.org/000000026228522X
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$a Lopez-Sublet, Marilucy $u AP-HP, Unité d'hypertension artérielle, service de médecine interne, Hôpital Avicenne, Bobigny, France $u INSERM UMR 942 MASCOT, Paris 13-Université Paris Nord, FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Bobigny, France
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$a Manolis, Athanasios $u Metropolitan Hospital, Piraeus, Greece $1 https://orcid.org/0000000242734489
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$a Marketou, Maria $u Hypertension Outpatient Clinic, Cardiology Department, Heraklion University General Hospital, Heraklion, Greece
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$a Mayer, Gert $u Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck Anichstrasse, Innsbruck, Austria $1 https://orcid.org/0000000346051789
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$a Mazza, Alberto $u Internal Medicine Unit, Department of Medicine, ESH Excellence Center Unit, Italy
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$a Veglio, Franco $u Department of Medical Sciences, University of Turin, Italy $1 https://orcid.org/0000000266546247
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$a Widimsky, Jiri $u IIIrd Internal Department, Centre for Hypertension, General Faculty Hospital, Charles University, Prague, Czech Republic
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$a Wuerzner, Gregoire $u Service de néphrologie et d'hypertension, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland $1 https://orcid.org/0000000264247630
700    1_
$a Zelveian, Parounak $u Center of Preventive Cardiology, Armenia Parounak Zelveian, Hospital N2 CJSC, Yerevan, Armenia $1 https://orcid.org/0000000265136772
700    1_
$a Zebekakis, Pantelis $u Hypertension Unit of the First Department of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
700    1_
$a Lueders, Stephan $u St. Josefs Hospital, Cloppenburg, Germany
700    1_
$a Persu, Alexandre $u Department of Cardiovascular Diseases, Division of Cardiology, Cliniques Universitaires Saint-Luc and Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
700    1_
$a Kreutz, Reinhold $u Institute of Clinical Pharmacology and Toxicology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
700    1_
$a Vogt, Liffert $u Department of Internal Medicine, Section of Nephrology, Amsterdam University Medical Center, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, the Netherlands
773    0_
$w MED00000810 $t Blood pressure $x 1651-1999 $g Roč. 33, č. 1 (2024), s. 2368800
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