• Something wrong with this record ?

Estimated number of lives directly saved by COVID-19 vaccination programmes in the WHO European Region from December, 2020, to March, 2023: a retrospective surveillance study

MMI. Meslé, J. Brown, P. Mook, MA. Katz, J. Hagan, R. Pastore, B. Benka, M. Redlberger-Fritz, N. Bossuyt, V. Stouten, C. Vernemmen, E. Constantinou, M. Maly, J. Kynčl, O. Sanca, TG. Krause, LS. Vestergaard, T. Leino, E. Poukka, K. Gkolfinopoulou,...

. 2024 ; 12 (9) : 714-727. [pub] 20240807

Language English Country England, Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc24019066

BACKGROUND: By March, 2023, 54 countries, areas, and territories (hereafter CAT) in the WHO European Region had reported more than 2·2 million COVID-19-related deaths to the WHO Regional Office for Europe. Here, we estimated how many lives were directly saved by vaccinating adults in the WHO European Region from December, 2020, to March, 2023. METHODS: In this retrospective surveillance study, we estimated the number of lives directly saved by age group, vaccine dose, and circulating variant-of-concern (VOC) period, regionally and nationally, using weekly data on COVID-19 mortality and infection, COVID-19 vaccination uptake, and SARS-CoV-2 virus characterisations by lineage downloaded from The European Surveillance System on June 11, 2023, as well as vaccine effectiveness data from the literature. We included data for six age groups (25-49 years, 50-59 years, ≥60 years, 60-69 years, 70-79 years, and ≥80 years). To be included in the analysis, CAT needed to have reported both COVID-19 vaccination and mortality data for at least one of the four older age groups. Only CAT that reported weekly data for both COVID-19 vaccination and mortality by age group for 90% of study weeks or more in the full study period were included. We calculated the percentage reduction in the number of expected and reported deaths. FINDINGS: Between December, 2020, and March, 2023, in 34 of 54 CAT included in the analysis, COVID-19 vaccines reduced deaths by 59% overall (CAT range 17-82%), representing approximately 1·6 million lives saved (range 1·5-1·7 million) in those aged 25 years or older: 96% of lives saved were aged 60 years or older and 52% were aged 80 years or older; first boosters saved 51% of lives, and 60% were saved during the Omicron period. INTERPRETATION: Over nearly 2·5 years, most lives saved by COVID-19 vaccination were in older adults by first booster dose and during the Omicron period, reinforcing the importance of up-to-date vaccination among the most at-risk individuals. Further modelling work should evaluate indirect effects of vaccination and public health and social measures. FUNDING: US Centers for Disease Control and Prevention.

3rd Faculty of Medicine Charles University Prague Czechia

Cantacuzino National Military Medical Institute for Research and Development Bucharest Romania

Centre for Health Security and Communicable Disease Control Reykjavik Iceland

Directorate of Disease Prevention and Health Promotion Directorate General of Health Lisbon Portugal

Directorate of Information and Analysis Directorate General of Health Lisbon Portugal

Finnish Institute for Health and Welfare Helsinki Finland

Health Directorate Luxembourg Luxembourg

Health Service Executive Health Protection Surveillance Centre Dublin Ireland

Hellenic National Public Health Organization Athens Greece

Infectious Disease Prevention and Control Unit Health Promotion and Disease Prevention Directorate Pietà Malta

Institute of Health Information and Statistics of the Czech Republic Nové Město Czechia

Institute of Public Health of Republic of North Macedonia Skopje North Macedonia

Instituto de Salud Carlos 3 Madrid Spain

Istituto Superiore di Sanità Rome Italy

Medical and Public Health Services Ministry of Health Nicosia Cyprus

Medical University Vienna Austria

Ministry of Health Madrid Spain

National Agency for Public Health Chisinau Moldova

National Center for Public Health and Pharmacy Budapest Hungary

National Health Institute Doutor Ricardo Jorge Lisbon Portugal

National Institute of Public Health Bucureşti Romania

National Institute of Public Health Ljubljana Slovenia

National Institute of Public Health Prague Czechia

National Public Health Center under the Ministry of Health Vilnius Lithuania

Norwegian Institute of Public Health Oslo Norway

Österreichische Agentur für Gesundheit und Ernährungssicherheit Vienna Austria

Public Health Scotland Glasgow UK

Regional Public Health Authority Banská Bystrica Slovakia

Sciensano Brussels Belgium

Statens Serum Institute Copenhagen Denmark

UK Health Security Agency London UK

World Health Organization Regional Office for Europe Copenhagen Denmark

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24019066
003      
CZ-PrNML
005      
20241024111603.0
007      
ta
008      
241015s2024 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/S2213-2600(24)00179-6 $2 doi
035    __
$a (PubMed)39127051
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Meslé, Margaux M I $u World Health Organization Regional Office for Europe, Copenhagen, Denmark. Electronic address: meslem@who.int
245    10
$a Estimated number of lives directly saved by COVID-19 vaccination programmes in the WHO European Region from December, 2020, to March, 2023: a retrospective surveillance study / $c MMI. Meslé, J. Brown, P. Mook, MA. Katz, J. Hagan, R. Pastore, B. Benka, M. Redlberger-Fritz, N. Bossuyt, V. Stouten, C. Vernemmen, E. Constantinou, M. Maly, J. Kynčl, O. Sanca, TG. Krause, LS. Vestergaard, T. Leino, E. Poukka, K. Gkolfinopoulou, K. Mellou, M. Tsintziloni, Z. Molnár, G. Aspelund, M. Thordardottir, L. Domegan, E. Kelly, J. O'Donell, AM. Urdiales, F. Riccardo, C. Sacco, V. Bumšteinas, R. Liausediene, J. Mossong, A. Vergison, ML. Borg, T. Melillo, D. Kocinski, E. Pollozhani, H. Meijerink, D. Costa, JP. Gomes, PP. Leite, A. Druc, V. Gutu, V. Mita, M. Lazar, R. Popescu, O. Popovici, M. Musilová, M. Mrzel, M. Socan, V. Učakar, A. Limia, C. Mazagatos, C. Olmedo, G. Dabrera, M. Kall, M. Sinnathamby, G. McGowan, J. McMenamin, K. Morrison, D. Nitzan, MA. Widdowson, C. Smallwood, R. Pebody, WHO European Respiratory Surveillance Network
520    9_
$a BACKGROUND: By March, 2023, 54 countries, areas, and territories (hereafter CAT) in the WHO European Region had reported more than 2·2 million COVID-19-related deaths to the WHO Regional Office for Europe. Here, we estimated how many lives were directly saved by vaccinating adults in the WHO European Region from December, 2020, to March, 2023. METHODS: In this retrospective surveillance study, we estimated the number of lives directly saved by age group, vaccine dose, and circulating variant-of-concern (VOC) period, regionally and nationally, using weekly data on COVID-19 mortality and infection, COVID-19 vaccination uptake, and SARS-CoV-2 virus characterisations by lineage downloaded from The European Surveillance System on June 11, 2023, as well as vaccine effectiveness data from the literature. We included data for six age groups (25-49 years, 50-59 years, ≥60 years, 60-69 years, 70-79 years, and ≥80 years). To be included in the analysis, CAT needed to have reported both COVID-19 vaccination and mortality data for at least one of the four older age groups. Only CAT that reported weekly data for both COVID-19 vaccination and mortality by age group for 90% of study weeks or more in the full study period were included. We calculated the percentage reduction in the number of expected and reported deaths. FINDINGS: Between December, 2020, and March, 2023, in 34 of 54 CAT included in the analysis, COVID-19 vaccines reduced deaths by 59% overall (CAT range 17-82%), representing approximately 1·6 million lives saved (range 1·5-1·7 million) in those aged 25 years or older: 96% of lives saved were aged 60 years or older and 52% were aged 80 years or older; first boosters saved 51% of lives, and 60% were saved during the Omicron period. INTERPRETATION: Over nearly 2·5 years, most lives saved by COVID-19 vaccination were in older adults by first booster dose and during the Omicron period, reinforcing the importance of up-to-date vaccination among the most at-risk individuals. Further modelling work should evaluate indirect effects of vaccination and public health and social measures. FUNDING: US Centers for Disease Control and Prevention.
650    _2
$a lidé $7 D006801
650    12
$a COVID-19 $x prevence a kontrola $x mortalita $x epidemiologie $7 D000086382
650    _2
$a retrospektivní studie $7 D012189
650    _2
$a lidé středního věku $7 D008875
650    _2
$a senioři $7 D000368
650    12
$a vakcíny proti COVID-19 $x aplikace a dávkování $7 D000086663
650    _2
$a dospělí $7 D000328
650    _2
$a senioři nad 80 let $7 D000369
650    12
$a SARS-CoV-2 $x imunologie $7 D000086402
650    _2
$a očkovací programy $x statistika a číselné údaje $7 D017589
650    _2
$a Světová zdravotnická organizace $7 D014944
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a ženské pohlaví $7 D005260
651    _2
$a Evropa $x epidemiologie $7 D005060
655    _2
$a časopisecké články $7 D016428
700    1_
$a Brown, Jeremy $u World Health Organization Regional Office for Europe, Copenhagen, Denmark
700    1_
$a Mook, Piers $u World Health Organization Regional Office for Europe, Copenhagen, Denmark
700    1_
$a Katz, Mark A $u World Health Organization Regional Office for Europe, Copenhagen, Denmark
700    1_
$a Hagan, José $u World Health Organization Regional Office for Europe, Copenhagen, Denmark
700    1_
$a Pastore, Roberta $u World Health Organization Regional Office for Europe, Copenhagen, Denmark
700    1_
$a Benka, Bernhard $u Österreichische Agentur für Gesundheit und Ernährungssicherheit, Vienna, Austria
700    1_
$a Redlberger-Fritz, Monika $u Medical University, Vienna, Austria
700    1_
$a Bossuyt, Nathalie $u Sciensano, Brussels, Belgium
700    1_
$a Stouten, Veerle $u Sciensano, Brussels, Belgium
700    1_
$a Vernemmen, Catharina $u Sciensano, Brussels, Belgium
700    1_
$a Constantinou, Elisabet $u Medical and Public Health Services, Ministry of Health, Nicosia, Cyprus
700    1_
$a Maly, Marek $u National Institute of Public Health, Prague, Czechia
700    1_
$a Kynčl, Jan $u National Institute of Public Health, Prague, Czechia; Third Faculty of Medicine, Charles University, Prague, Czechia
700    1_
$a Sanca, Ondrej $u Institute of Health Information and Statistics of the Czech Republic, Nové Město, Czechia
700    1_
$a Krause, Tyra Grove $u Statens Serum Institute, Copenhagen, Denmark
700    1_
$a Vestergaard, Lasse Skafte $u Statens Serum Institute, Copenhagen, Denmark
700    1_
$a Leino, Tuija $u Finnish Institute for Health and Welfare, Helsinki, Finland
700    1_
$a Poukka, Eero $u Finnish Institute for Health and Welfare, Helsinki, Finland
700    1_
$a Gkolfinopoulou, Kassiani $u Hellenic National Public Health Organization, Athens, Greece
700    1_
$a Mellou, Kassiani $u Hellenic National Public Health Organization, Athens, Greece
700    1_
$a Tsintziloni, Maria $u Hellenic National Public Health Organization, Athens, Greece
700    1_
$a Molnár, Zsuzsanna $u National Center for Public Health and Pharmacy, Budapest, Hungary
700    1_
$a Aspelund, Gudrun $u Centre for Health Security and Communicable Disease Control, Reykjavik, Iceland
700    1_
$a Thordardottir, Marianna $u Centre for Health Security and Communicable Disease Control, Reykjavik, Iceland
700    1_
$a Domegan, Lisa $u Health Service Executive-Health Protection Surveillance Centre, Dublin, Ireland
700    1_
$a Kelly, Eva $u Health Service Executive-Health Protection Surveillance Centre, Dublin, Ireland
700    1_
$a O'Donell, Joan $u Health Service Executive-Health Protection Surveillance Centre, Dublin, Ireland
700    1_
$a Urdiales, Alberto-Mateo $u Istituto Superiore di Sanità, Rome, Italy
700    1_
$a Riccardo, Flavia $u Istituto Superiore di Sanità, Rome, Italy
700    1_
$a Sacco, Chiara $u Istituto Superiore di Sanità, Rome, Italy
700    1_
$a Bumšteinas, Viktoras $u National Public Health Center under the Ministry of Health, Vilnius, Lithuania
700    1_
$a Liausediene, Rasa $u National Public Health Center under the Ministry of Health, Vilnius, Lithuania
700    1_
$a Mossong, Joël $u Health Directorate, Luxembourg, Luxembourg
700    1_
$a Vergison, Anne $u Health Directorate, Luxembourg, Luxembourg
700    1_
$a Borg, Maria-Louise $u Infectious Disease Prevention and Control Unit, Health Promotion and Disease Prevention Directorate, Pietà, Malta
700    1_
$a Melillo, Tanya $u Infectious Disease Prevention and Control Unit, Health Promotion and Disease Prevention Directorate, Pietà, Malta
700    1_
$a Kocinski, Dragan $u Institute of Public Health of Republic of North Macedonia, Skopje, North Macedonia
700    1_
$a Pollozhani, Enkela $u Institute of Public Health of Republic of North Macedonia, Skopje, North Macedonia
700    1_
$a Meijerink, Hinta $u Norwegian Institute of Public Health, Oslo, Norway
700    1_
$a Costa, Diana $u Directorate of Disease Prevention and Health Promotion, Directorate-General of Health, Lisbon, Portugal
700    1_
$a Gomes, João Paulo $u National Health Institute Doutor Ricardo Jorge, Lisbon, Portugal
700    1_
$a Leite, Pedro Pinto $u Directorate of Information and Analysis, Directorate-General of Health, Lisbon, Portugal
700    1_
$a Druc, Alina $u National Agency for Public Health, Chisinau, Moldova
700    1_
$a Gutu, Veaceslav $u National Agency for Public Health, Chisinau, Moldova
700    1_
$a Mita, Valentin $u National Agency for Public Health, Chisinau, Moldova
700    1_
$a Lazar, Mihaela $u Cantacuzino National Military Medical Institute for Research and Development, Bucharest, Romania
700    1_
$a Popescu, Rodica $u National Institute of Public Health, Bucureşti, Romania
700    1_
$a Popovici, Odette $u National Institute of Public Health, Bucureşti, Romania
700    1_
$a Musilová, Monika $u Regional Public Health Authority, Banská Bystrica, Slovakia
700    1_
$a Mrzel, Maja $u National Institute of Public Health, Ljubljana, Slovenia
700    1_
$a Socan, Maja $u National Institute of Public Health, Ljubljana, Slovenia
700    1_
$a Učakar, Veronika $u National Institute of Public Health, Ljubljana, Slovenia
700    1_
$a Limia, Aurora $u Ministry of Health, Madrid, Spain
700    1_
$a Mazagatos, Clara $u Instituto de Salud Carlos III, Madrid, Spain
700    1_
$a Olmedo, Carmen $u Ministry of Health, Madrid, Spain
700    1_
$a Dabrera, Gavin $u UK Health Security Agency, London, UK
700    1_
$a Kall, Meaghan $u UK Health Security Agency, London, UK
700    1_
$a Sinnathamby, Mary $u UK Health Security Agency, London, UK
700    1_
$a McGowan, Graham $u Public Health Scotland, Glasgow, UK
700    1_
$a McMenamin, Jim $u Public Health Scotland, Glasgow, UK
700    1_
$a Morrison, Kirsty $u Public Health Scotland, Glasgow, UK
700    1_
$a Nitzan, Dorit $u World Health Organization Regional Office for Europe, Copenhagen, Denmark
700    1_
$a Widdowson, Marc-Alain $u World Health Organization Regional Office for Europe, Copenhagen, Denmark
700    1_
$a Smallwood, Catherine $u World Health Organization Regional Office for Europe, Copenhagen, Denmark
700    1_
$a Pebody, Richard $u World Health Organization Regional Office for Europe, Copenhagen, Denmark
710    2_
$a WHO European Respiratory Surveillance Network
773    0_
$w MED00188827 $t The Lancet. Respiratory medicine $x 2213-2619 $g Roč. 12, č. 9 (2024), s. 714-727
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39127051 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20241015 $b ABA008
991    __
$a 20241024111556 $b ABA008
999    __
$a ok $b bmc $g 2201719 $s 1231039
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 12 $c 9 $d 714-727 $e 20240807 $i 2213-2619 $m The Lancet. Respiratory medicine $n Lancet Respir Med $x MED00188827
LZP    __
$a Pubmed-20241015

Find record

Citation metrics

Archiving options