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Role of compliance in Helicobacter pylori eradication treatment: Results of the European Registry on H. pylori management
JM. Huguet, L. Ferrer-Barceló, P. Suárez, S. Barcelo-Cerda, J. Sempere, IM. Saracino, G. Fiorini, D. Vaira, Á. Pérez-Aísa, L. Jonaitis, B. Tepes, M. Castro-Fernandez, M. Pabón-Carrasco, A. Keco-Huerga, I. Voynovan, AJ. Lucendo, Á. Lanas, SJ....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
10058099
UK Research and Innovation
101095359
HORIZON EUROPE European Innovation Council
101101252
European Union programme EU4Health
DIASORIN
NLK
Free Medical Journals
od 2013
PubMed Central
od 2013
Europe PubMed Central
od 2013
ProQuest Central
od 2021-02-01
Health & Medicine (ProQuest)
od 2021-02-01
Wiley-Blackwell Open Access Titles
od 2013
ROAD: Directory of Open Access Scholarly Resources
od 2013
PubMed
38685613
DOI
10.1002/ueg2.12569
Knihovny.cz E-zdroje
- MeSH
- adherence k farmakoterapii * statistika a číselné údaje MeSH
- amoxicilin * terapeutické užití aplikace a dávkování MeSH
- antibakteriální látky * terapeutické užití škodlivé účinky MeSH
- bismut terapeutické užití aplikace a dávkování škodlivé účinky MeSH
- dospělí MeSH
- dyspepsie farmakoterapie mikrobiologie MeSH
- Helicobacter pylori * účinky léků MeSH
- infekce vyvolané Helicobacter pylori * farmakoterapie MeSH
- inhibitory protonové pumpy * terapeutické užití aplikace a dávkování MeSH
- klarithromycin terapeutické užití MeSH
- kombinovaná farmakoterapie * MeSH
- lidé středního věku MeSH
- lidé MeSH
- metronidazol terapeutické užití aplikace a dávkování MeSH
- prospektivní studie MeSH
- registrace * MeSH
- senioři MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
BACKGROUND: Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone for achieving adequate treatment efficacy. OBJECTIVE: To determine which factors influence compliance with treatment. METHODS: A systematic prospective non-interventional registry (Hp-EuReg) of the clinical practice of European gastroenterologists. Compliance was considered adequate if ≥90% drug intake. Data were collected until September 2021 using the AEG-REDCap e-CRF and were subjected to quality control. Modified intention-to-treat analyses were performed. Multivariate analysis carried out the factors associated with the effectiveness of treatment and compliance. RESULTS: Compliance was inadequate in 646 (1.7%) of 38,698 patients. The non-compliance rate was higher in patients prescribed longer regimens (10-, 14-days) and rescue treatments, patients with uninvestigated dyspepsia/functional dyspepsia, and patients reporting adverse effects. Prevalence of non-adherence was lower for first-line treatment than for rescue treatment (1.5% vs. 2.2%; p < 0.001). Differences in non-adherence in the three most frequent first-line treatments were shown: 1.1% with proton pump inhibitor + clarithromycin + amoxicillin; 2.3% with proton pump inhibitor clarithromycin amoxicillin metronidazole; and 1.8% with bismuth quadruple therapy. These treatments were significantly more effective in compliant than in non-compliant patients: 86% versus 44%, 90% versus 71%, and 93% versus 64%, respectively (p < 0.001). In the multivariate analysis, the variable most significantly associated with higher effectiveness was adequate compliance (odds ratio, 6.3 [95%CI, 5.2-7.7]; p < 0.001). CONCLUSIONS: Compliance with Helicobacter pylori eradication treatment is very good. Factors associated with poor compliance include uninvestigated/functional dyspepsia, rescue-treatment, prolonged treatment regimens, the presence of adverse events, and the use of non-bismuth sequential and concomitant treatment. Adequate treatment compliance was the variable most closely associated with successful eradication.
CIBER de enfermedades Hepáticas y Digestiva Madrid Spain
Cintesis Center for Research in Health Technologies and Information Systems Porto Portugal
Department of Digestive Disorders Aberdeen Royal Infirmary Aberdeen UK
Department of Gastroenterology A S Loginov Moscow Clinical Scientific Center Moscow Russia
Department of Gastroenterology AM DC Rogaska Rogaska Slatina Slovenia
Department of Gastroenterology and Hepatology Meander Medical Center Amersfoort Netherlands
Department of Gastroenterology CHRU de Nantes Hôpital Hôtel Dieu Nantes France
Department of Gastroenterology Digestive Diseases Centre Riga Latvia
Department of Gastroenterology Ferencváros Health Centre Budapest Hungary
Department of Gastroenterology Gastrocentr Perm Russia
Department of Gastroenterology Henry Dunant Hospital Athens Greece
Department of Gastroenterology Hospital General de Tomelloso Tomelloso Spain
Department of Gastroenterology Hospital General Universitario de Valencia Valencia Spain
Department of Gastroenterology Lithuanian University of Health Sciences Kaunas Lithuania
Department of Gastroenterology Medical Microbiology Medical University of Sofia Sofia Bulgaria
Department of Gastroenterology Østfold Hospital Trust Grålum Norway
Department of Gastroenterology Pomeranian Medical University in Szczecin Szczecin Poland
Department of Gastroenterology University of Oviedo Oviedo Spain
Department of Internal Medicine 2nd Faculty of Medicine Charles University Prague Czech Republic
Department of Outpatient Therapy and Family Medicine Tver State Medical University Tver Russia
Division of Gastroenterology and Hepatology Hacettepe University School of Medicine Ankara Turkey
Division of Gastroenterology Rabin Medical Center Petah Tikva Israel
Faculty of Health Sciences Trinity College Dublin Dublin Ireland
Gastroklinik Private Gastroenterological Practice Horgen Switzerland
GOES Research Group Althaia Xarxa Assistencial Universitària de Manresa Manresa Spain
Hospital Universitario de La Princesa Instituto de Investigación Sanitaria Princesa Madrid Spain
INSERM U1312 Université de Bordeaux Bordeaux France
Institute of Clinical and Preventive Medicine University of Latvia Riga Latvia
Instituto de Investigación Sanitaria de Aragón Zaragoza Spain
Instituto de Investigación Sanitaria de Castilla La Mancha Tomelloso Spain
Instituto de Investigación Sanitaria La Princesa Madrid Spain
IRCCS S Orsola Polyclinic University of Bologna Bologna Italy
Memorial Clinic Baku Azerbaijan
Sackler School of Medicine Tel Aviv University Tel Aviv Israel
Servicio de Aparato Digestivo Hospital Clínico Universitario Lozano Blesa Zaragoza Spain
The Centre for Digestive Diseases Endoklinika Szczecin Poland
Unidad de Aparato Digestivo Hospital Universitario de Valme Sevilla Spain
Citace poskytuje Crossref.org
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- $a Huguet, Jose M $u Department of Gastroenterology, Hospital General Universitario de Valencia, Valencia, Spain $1 https://orcid.org/0000000164861262
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