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Role of compliance in Helicobacter pylori eradication treatment: Results of the European Registry on H. pylori management
JM. Huguet, L. Ferrer-Barceló, P. Suárez, S. Barcelo-Cerda, J. Sempere, IM. Saracino, G. Fiorini, D. Vaira, Á. Pérez-Aísa, L. Jonaitis, B. Tepes, M. Castro-Fernandez, M. Pabón-Carrasco, A. Keco-Huerga, I. Voynovan, AJ. Lucendo, Á. Lanas, SJ....
Language English Country England, Great Britain
Document type Journal Article
Grant support
10058099
UK Research and Innovation
101095359
HORIZON EUROPE European Innovation Council
101101252
European Union programme EU4Health
DIASORIN
NLK
Free Medical Journals
from 2013
PubMed Central
from 2013
Europe PubMed Central
from 2013
ProQuest Central
from 2021-02-01
Health & Medicine (ProQuest)
from 2021-02-01
Wiley-Blackwell Open Access Titles
from 2013
ROAD: Directory of Open Access Scholarly Resources
from 2013
PubMed
38685613
DOI
10.1002/ueg2.12569
Knihovny.cz E-resources
- MeSH
- Medication Adherence * statistics & numerical data MeSH
- Amoxicillin * therapeutic use administration & dosage MeSH
- Anti-Bacterial Agents * therapeutic use adverse effects MeSH
- Bismuth therapeutic use administration & dosage adverse effects MeSH
- Adult MeSH
- Dyspepsia drug therapy microbiology MeSH
- Helicobacter pylori * drug effects MeSH
- Helicobacter Infections * drug therapy MeSH
- Proton Pump Inhibitors * therapeutic use administration & dosage MeSH
- Clarithromycin therapeutic use MeSH
- Drug Therapy, Combination * MeSH
- Middle Aged MeSH
- Humans MeSH
- Metronidazole therapeutic use administration & dosage MeSH
- Prospective Studies MeSH
- Registries * MeSH
- Aged MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Europe MeSH
BACKGROUND: Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone for achieving adequate treatment efficacy. OBJECTIVE: To determine which factors influence compliance with treatment. METHODS: A systematic prospective non-interventional registry (Hp-EuReg) of the clinical practice of European gastroenterologists. Compliance was considered adequate if ≥90% drug intake. Data were collected until September 2021 using the AEG-REDCap e-CRF and were subjected to quality control. Modified intention-to-treat analyses were performed. Multivariate analysis carried out the factors associated with the effectiveness of treatment and compliance. RESULTS: Compliance was inadequate in 646 (1.7%) of 38,698 patients. The non-compliance rate was higher in patients prescribed longer regimens (10-, 14-days) and rescue treatments, patients with uninvestigated dyspepsia/functional dyspepsia, and patients reporting adverse effects. Prevalence of non-adherence was lower for first-line treatment than for rescue treatment (1.5% vs. 2.2%; p < 0.001). Differences in non-adherence in the three most frequent first-line treatments were shown: 1.1% with proton pump inhibitor + clarithromycin + amoxicillin; 2.3% with proton pump inhibitor clarithromycin amoxicillin metronidazole; and 1.8% with bismuth quadruple therapy. These treatments were significantly more effective in compliant than in non-compliant patients: 86% versus 44%, 90% versus 71%, and 93% versus 64%, respectively (p < 0.001). In the multivariate analysis, the variable most significantly associated with higher effectiveness was adequate compliance (odds ratio, 6.3 [95%CI, 5.2-7.7]; p < 0.001). CONCLUSIONS: Compliance with Helicobacter pylori eradication treatment is very good. Factors associated with poor compliance include uninvestigated/functional dyspepsia, rescue-treatment, prolonged treatment regimens, the presence of adverse events, and the use of non-bismuth sequential and concomitant treatment. Adequate treatment compliance was the variable most closely associated with successful eradication.
CIBER de enfermedades Hepáticas y Digestiva Madrid Spain
Cintesis Center for Research in Health Technologies and Information Systems Porto Portugal
Department of Digestive Disorders Aberdeen Royal Infirmary Aberdeen UK
Department of Gastroenterology A S Loginov Moscow Clinical Scientific Center Moscow Russia
Department of Gastroenterology AM DC Rogaska Rogaska Slatina Slovenia
Department of Gastroenterology and Hepatology Meander Medical Center Amersfoort Netherlands
Department of Gastroenterology CHRU de Nantes Hôpital Hôtel Dieu Nantes France
Department of Gastroenterology Digestive Diseases Centre Riga Latvia
Department of Gastroenterology Ferencváros Health Centre Budapest Hungary
Department of Gastroenterology Gastrocentr Perm Russia
Department of Gastroenterology Henry Dunant Hospital Athens Greece
Department of Gastroenterology Hospital General de Tomelloso Tomelloso Spain
Department of Gastroenterology Hospital General Universitario de Valencia Valencia Spain
Department of Gastroenterology Lithuanian University of Health Sciences Kaunas Lithuania
Department of Gastroenterology Medical Microbiology Medical University of Sofia Sofia Bulgaria
Department of Gastroenterology Østfold Hospital Trust Grålum Norway
Department of Gastroenterology Pomeranian Medical University in Szczecin Szczecin Poland
Department of Gastroenterology University of Oviedo Oviedo Spain
Department of Internal Medicine 2nd Faculty of Medicine Charles University Prague Czech Republic
Department of Outpatient Therapy and Family Medicine Tver State Medical University Tver Russia
Division of Gastroenterology and Hepatology Hacettepe University School of Medicine Ankara Turkey
Division of Gastroenterology Rabin Medical Center Petah Tikva Israel
Faculty of Health Sciences Trinity College Dublin Dublin Ireland
Gastroklinik Private Gastroenterological Practice Horgen Switzerland
GOES Research Group Althaia Xarxa Assistencial Universitària de Manresa Manresa Spain
Hospital Universitario de La Princesa Instituto de Investigación Sanitaria Princesa Madrid Spain
INSERM U1312 Université de Bordeaux Bordeaux France
Institute of Clinical and Preventive Medicine University of Latvia Riga Latvia
Instituto de Investigación Sanitaria de Aragón Zaragoza Spain
Instituto de Investigación Sanitaria de Castilla La Mancha Tomelloso Spain
Instituto de Investigación Sanitaria La Princesa Madrid Spain
IRCCS S Orsola Polyclinic University of Bologna Bologna Italy
Memorial Clinic Baku Azerbaijan
Sackler School of Medicine Tel Aviv University Tel Aviv Israel
Servicio de Aparato Digestivo Hospital Clínico Universitario Lozano Blesa Zaragoza Spain
The Centre for Digestive Diseases Endoklinika Szczecin Poland
Unidad de Aparato Digestivo Hospital Universitario de Valme Sevilla Spain
References provided by Crossref.org
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