• Je něco špatně v tomto záznamu ?

Impaired Dynamics of Positional and Contextual Neural Coding in an Alzheimer's Disease Rat Model

A. Nataraj, A. Kala, SL. Proskauer Pena, K. Jezek, K. Blahna

. 2024 ; 101 (1) : 259-276. [pub] -

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24020021

BACKGROUND: The hippocampal representation of space, formed by the collective activity of populations of place cells, is considered as a substrate of spatial memory. Alzheimer's disease (AD), a widespread severe neurodegenerative condition of multifactorial origin, typically exhibits spatial memory deficits among its early clinical signs before more severe cognitive impacts develop. OBJECTIVE: To investigate mechanisms of spatial memory impairment in a double transgenic rat model of AD. METHODS: In this study, we utilized 9-12-month-old double-transgenic TgF344-AD rats and age-matched controls to analyze the spatial coding properties of CA1 place cells. We characterized the spatial memory representation, assessed cells' spatial information content and direction-specific activity, and compared their population coding in familiar and novel conditions. RESULTS: Our findings revealed that TgF344-AD animals exhibited lower precision in coding, as evidenced by reduced spatial information and larger receptive zones. This impairment was evident in maps representing novel environments. While controls instantly encoded directional context during their initial exposure to a novel environment, transgenics struggled to incorporate this information into the newly developed hippocampal spatial representation. This resulted in impairment in orthogonalization of stored activity patterns, an important feature directly related to episodic memory encoding capacity. CONCLUSIONS: Overall, the results shed light on the nature of impairment at both the single-cell and population levels in the transgenic AD model. In addition to the observed spatial coding inaccuracy, the findings reveal a significantly impaired ability to adaptively modify and refine newly stored hippocampal memory patterns.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24020021
003      
CZ-PrNML
005      
20250424104330.0
007      
ta
008      
241015s2024 ne f 000 0|eng||
009      
AR
024    7_
$a 10.3233/JAD-231386 $2 doi
035    __
$a (PubMed)39177594
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Nataraj, Athira $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, , Prague, Czech Republic $7 xx0331467
245    10
$a Impaired Dynamics of Positional and Contextual Neural Coding in an Alzheimer's Disease Rat Model / $c A. Nataraj, A. Kala, SL. Proskauer Pena, K. Jezek, K. Blahna
520    9_
$a BACKGROUND: The hippocampal representation of space, formed by the collective activity of populations of place cells, is considered as a substrate of spatial memory. Alzheimer's disease (AD), a widespread severe neurodegenerative condition of multifactorial origin, typically exhibits spatial memory deficits among its early clinical signs before more severe cognitive impacts develop. OBJECTIVE: To investigate mechanisms of spatial memory impairment in a double transgenic rat model of AD. METHODS: In this study, we utilized 9-12-month-old double-transgenic TgF344-AD rats and age-matched controls to analyze the spatial coding properties of CA1 place cells. We characterized the spatial memory representation, assessed cells' spatial information content and direction-specific activity, and compared their population coding in familiar and novel conditions. RESULTS: Our findings revealed that TgF344-AD animals exhibited lower precision in coding, as evidenced by reduced spatial information and larger receptive zones. This impairment was evident in maps representing novel environments. While controls instantly encoded directional context during their initial exposure to a novel environment, transgenics struggled to incorporate this information into the newly developed hippocampal spatial representation. This resulted in impairment in orthogonalization of stored activity patterns, an important feature directly related to episodic memory encoding capacity. CONCLUSIONS: Overall, the results shed light on the nature of impairment at both the single-cell and population levels in the transgenic AD model. In addition to the observed spatial coding inaccuracy, the findings reveal a significantly impaired ability to adaptively modify and refine newly stored hippocampal memory patterns.
650    _2
$a zvířata $7 D000818
650    12
$a Alzheimerova nemoc $x patofyziologie $7 D000544
650    12
$a potkani transgenní $7 D055647
650    12
$a modely nemocí na zvířatech $7 D004195
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a prostorová paměť $x fyziologie $7 D065852
650    _2
$a potkani inbrední F344 $7 D011916
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a hipokampální oblast CA1 $x patofyziologie $7 D056547
650    _2
$a amyloidový prekurzorový protein beta $x genetika $7 D016564
650    _2
$a lidé $7 D006801
650    _2
$a poruchy paměti $x etiologie $x patofyziologie $7 D008569
650    _2
$a hipokampus $x patofyziologie $7 D006624
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kala, Annu $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, , Prague, Czech Republic
700    1_
$a Proskauer Peña, Stephanie $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, , Prague, Czech Republic $7 xx0327367
700    1_
$a Jezek, Karel $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, , Prague, Czech Republic
700    1_
$a Blahna, Karel $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, , Prague, Czech Republic
773    0_
$w MED00006350 $t Journal of Alzheimer's disease : JAD $x 1875-8908 $g Roč. 101, č. 1 (2024), s. 259-276
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39177594 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20241015 $b ABA008
991    __
$a 20250424104329 $b ABA008
999    __
$a ok $b bmc $g 2202322 $s 1231994
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 101 $c 1 $d 259-276 $e - $i 1875-8908 $m Journal of Alzheimer's disease : JAD $n J Alzheimers Dis $x MED00006350
LZP    __
$a Pubmed-20241015

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...